[PDF] Top 20 Prospective Evaluation of a Whole-Blood Test Using Mycobacterium tuberculosis-Specific Antigens ESAT-6 and CFP-10 for Diagnosis of Active Tuberculosis
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Prospective Evaluation of a Whole-Blood Test Using Mycobacterium tuberculosis-Specific Antigens ESAT-6 and CFP-10 for Diagnosis of Active Tuberculosis
... diagnostic test can exclude infection with M. tuberculosis, and to ensure the most correct classification of the patients in this study, all TB patients were followed to the end of treatment and all the ... See full document
6
Selected Pool of Peptides from ESAT 6 and CFP 10 Proteins for Detection of Mycobacterium tuberculosis Infection
... the diagnosis for TB is a combina- tion of clinical and radiologic examination and microbiological tests, both microscopic and cultural (the last one can take up to 8 weeks, and in 10 to 20% of cases ... See full document
6
Rapid Identification of the Mycobacterium tuberculosis Complex by Combining the ESAT 6/CFP 10 Immunochromatographic Assay and Smear Morphology
... antigen 6 (ESAT-6, 6 kDa) and cell filtrate protein 10 (CFP-10, 10 kDa) are two specific MTC ...two antigens have been applied to the QuantiFERON ... See full document
6
Field Evaluation of a Novel Differential Diagnostic Reagent for Detection of Mycobacterium bovis in Cattle
... (e.g., ESAT-6 and CFP-10) (12, 19, 20, 26, ...immunogenic antigens from genomic regions absent in BCG Pasteur, and 7 of 28 tested antigens were recognized at high frequencies by ... See full document
6
Enhanced Ex Vivo Stimulation of Mycobacterium tuberculosis-Specific T Cells in Human Immunodeficiency Virus-Infected Persons via Antigen Delivery by the Bordetella pertussis Adenylate Cyclase Vector
... in Mycobacterium tuber- culosis antigen discovery has led to new avenues for the diagnosis of TB (2, 5, ...studied antigens are region of difference 1 (RD1)-based early-se- creted antigenic target ... See full document
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Long-Incubation-Time Gamma Interferon Release Assays in Response to Purified Protein Derivative, ESAT-6, and/or CFP-10 for the Diagnosis of Mycobacterium tuberculosis Infection in Children
... the diagnosis of pedi- atric ...M. tuberculosis infection. Due to the limited amount of blood available from the child participants, we decided to focus our re- search on the evaluation of ... See full document
8
Diagnosis of Tuberculosis Based on the Two Specific Antigens ESAT-6 and CFP10
... mycobacterial antigens containing both secreted and somatic proteins, has been used for TB diagnosis and epidemiological studies for more than half a ...skin test reagent in both humans and ... See full document
6
Use of Whole-Blood Samples in In-House Bulk and Single-Cell Antigen-Specific Gamma Interferon Assays for Surveillance of Mycobacterium tuberculosis Infections
... with active tuberculosis and healthy controls upon stimulation with the PPD antigen, the SEB superantigen, or the CFP-10 or ESAT-6 ...M. tuberculosis-specific ... See full document
11
Evaluation of Gamma Interferon Release Assays Using Mycobacterium tuberculosis Antigens for Diagnosis of Latent and Active Tuberculosis in Mycobacterium bovis BCG-Vaccinated Populations
... (IGRAs) using Mycobacterium tuberculosis-specific antigens have shown higher sensitivity and specificity than the routine tuberculin skin test ...of Mycobacterium bovis ... See full document
6
Field Evaluation of a Rapid Immunochromatographic Test for Tuberculosis
... for tuberculosis (TB) are needed to facilitate early treatment of TB and prevention of Mycobacterium tuberculosis ...ICT Tuberculosis test is a rapid, card-based immunochromato- graphic ... See full document
5
Sensitivity Analysis and Potential Uses of a Novel Gamma Interferon Release Assay for Diagnosis of Tuberculosis
... heparinized blood collection tubes precoated with the three TB-specific antigens (ESAT-6, CFP-10, and an 18-mer peptide [AWRTAAVE LARALVRAVA] of ...of blood (1 ml ... See full document
7
Effect of Chemotherapy on Whole-Blood Cytokine Responses to Mycobacterium tuberculosis Antigens in a Small Cohort of Patients with Pulmonary Tuberculosis
... the diagnosis of latent TB infection, their utility in monitoring immune re- sponses during the course of chemotherapy for active TB dis- ease and in correlating IFN- ␥ levels after antigen stimulation with ... See full document
9
Use of Synthetic Peptides Derived from the Antigens ESAT-6 and CFP-10 for Differential Diagnosis of Bovine Tuberculosis in Cattle
... against Mycobacterium bovis infection holds the best long-term prospect for tuberculosis control in British ...diagnostic test to differentiate between vaccinated animals and those infected with ... See full document
8
A T cell based assay using specific Mycobacterium tuberculosis antigens, ESAT-6 and CFP 10, for the diagnosis of Tuberculous Meningitis.
... M tuberculosis is associated with the development of a positive result in the tuberculin skin ...M tuberculosis interact with T lymphocytes via several important ...M tuberculosis in the ...M ... See full document
58
ESAT 6/CFP 10 Fusion Protein and Peptides for Optimal Diagnosis of Mycobacterium tuberculosis Infection by Ex Vivo Enzyme Linked Immunospot Assay in The Gambia
... the diagnosis of Mycobac- terium tuberculosis infection ...M. tuberculosis exposure according to sleeping proximity to an index tuberculosis (TB) ...case. Using this model, we showed ... See full document
5
Clinical Evaluation of TRCRapid M TB for Detection of Mycobacterium tuberculosis Complex in Respiratory and Nonrespiratory Specimens
... positive specimens. The detection time for this specimen was 1,756 s, which is extraordinarily slow, even though it was smear positive (the positive value was 3 plus, corresponding to a Gaffky scale score of 9). ... See full document
6
Evaluation of Gen Probe Amplified Mycobacterium Tuberculosis Direct Test by Using Respiratory and Nonrespiratory Specimens in a Tertiary Care Center Laboratory
... spect to distinct specimen types, e.g., acid-fast smear-positive or -negative specimens. The original AMTD assay was assessed in smear-positive respiratory specimens. More recent AMTD assay performance assessments have ... See full document
5
Relevance of Commercial Amplification Methods for Direct Detection of Mycobacterium tuberculosis Complex in Clinical Samples
... than those obtained from smear-negative samples (the ratio between MTB culture-positive and smear-positive samples ranged from 1.0 to 2.8; mean, 1.6) In general, the test per- formed well and offers several ... See full document
11
Original Article Cloning and characterization of Clp protease proteolytic subunit 2 and its implication in clinical diagnosis of tuberculosis
... characterize Mycobacterium tuberculosis (Mtb) ClpP2, and evaluated the potential usage of ClpP2 in clinical diagnosis of ...in tuberculosis patients, both the levels of ClpP2 antigen and ... See full document
9
Reproducibility of QuantiFERON-TB Gold In-Tube Assay
... ml whole blood was drawn into one (each) of three manufacturer-precoated heparinized tubes con- taining mitogen (phytohemagglutinin A), TB peptide antigens ESAT-6/CFP-10/ ... See full document
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