[PDF] Top 20 Protease-Mediated Entry via the Endosome of Human Coronavirus 229E
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Protease-Mediated Entry via the Endosome of Human Coronavirus 229E
... of 229E-infected HeLa ...on 229E-infected cells were quite similar to those relative to syn- cytium formation by SARS-CoV, as described previously ...using 229E virions, whether syncytium formation ... See full document
10
Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry
... the coronavirus S protein is a possible fusion peptide (19). The protease cleavage site might be located on the N-terminal side of this ...the 229E/lab S protein), except a mutation (I700L) within ... See full document
12
Middle East Respiratory Syndrome Coronavirus Infection Mediated by the Transmembrane Serine Protease TMPRSS2
... CoV entry, an authentic human coronavirus, 229E (HCoV-229E), proficient for infection of MRC-5 and WI-38 cells, was also tested in the virus entry assay in the presence of ... See full document
10
ATP1A1-Mediated Src Signaling Inhibits Coronavirus Entry into Host Cells
... CoV entry as we and others have described (6, 56–59): uptake of CoV in a preendosome that pinches off to form an early ...MHV entry, upstream of the inhibitory effect of compounds affecting dy- namin-2 ... See full document
15
TMPRSS2 Activates the Human Coronavirus 229E for Cathepsin-Independent Host Cell Entry and Is Expressed in Viral Target Cells in the Respiratory Epithelium
... with human coronavirus 229E (HCoV-229E) is associated with the common cold and may result in pneumonia in im- munocompromised ...infectious entry of HCoV-229E into host cells, a ... See full document
11
Anti-Severe Acute Respiratory Syndrome Coronavirus Spike Antibodies Trigger Infection of Human Immune Cells via a pH- and Cysteine Protease-Independent FcγR Pathway
... syndrome coronavirus (SARS-CoV) ...a human-adapted SARS-like coronavirus remains a plausible public health ...of human B cell lines despite eliciting in vivo a neutralizing and protective ... See full document
16
Human Coronavirus 229E Papain-Like Proteases Have Overlapping Specificities but Distinct Functions in Viral Replication
... production (24). By contrast, in HCoV-229E and probably other group 1 CoVs, similar or even overlapping substrate specificities have been retained, providing these viruses with some sort of “backup” mechanism to ... See full document
11
Simultaneous Treatment of Human Bronchial Epithelial Cells with Serine and Cysteine Protease Inhibitors Prevents Severe Acute Respiratory Syndrome Coronavirus Entry
... In the present study, we could not show the cleavage of SARS or NL63-S protein by TMPRSS2 because the cleavage products would be difficult to detect by Western blot analysis. We previ- ously reported that a considerable ... See full document
9
A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry
... 1,000-fold-enhanced entry. Are these two divergent protease activities completely redundant, or are there contexts in which TTSPs are specifi- cally required? Our hypothesis is that certain in vivo ... See full document
10
Heptad Repeat-Derived Peptides Block Protease-Mediated Direct Entry from the Cell Surface of Severe Acute Respiratory Syndrome Coronavirus but Not Entry via the Endosomal Pathway
... and human immunodeficiency virus (HIV)/SCoV-pseudotyped virus infec- tion (1, 18, 24, ...murine coronavirus mouse hepatitis virus (MHV) ...distinct entry pathways depending on the presence of ... See full document
5
Clathrin-mediated entry and cellular localization of chlorotoxin in human glioma
... To study the clathrin-dependent endocytic pathway of TM601 cellular uptake we used chlorpromazine which belongs to the cationic amphiphilic class (CAD) and phenothiazine class of drugs for mental disorders and is an ... See full document
13
Adenosine Deaminase Acts as a Natural Antagonist for Dipeptidyl Peptidase 4-Mediated Entry of the Middle East Respiratory Syndrome Coronavirus
... full-length human DPP4, ferret DPP4, or human-ferret DPP4 chimeras (human-ferret-human and ferret-human-ferret [HFH and FHF, respectively]) were ... See full document
5
Serological Responses in Patients with Severe Acute Respiratory Syndrome Coronavirus Infection and Cross-Reactivity with Human Coronaviruses 229E, OC43, and NL63
... other human coronaviruses 229E and ...OC43, 229E, or both (Table ...and 229E in animals immunized with SARS CoV and in human patients with SARS ...NL63 coronavirus. Since most ... See full document
5
Cell Entry of the Aphthovirus Equine Rhinitis A Virus Is Dependent on Endosome Acidification
... ERAV internalization and replication are prevented by a dominant negative inhibitor of clathrin-mediated endocytosis. Eps15 participates in clathrin-mediated endocytosis via its in- teraction with ... See full document
6
Na+/Ca2+ exchange mediated calcium entry in human lymphocytes
... in human peripheral blood lymphocytes, Ca2+ entry and cytosolic Ca2+ (measured with fura- 2) were monitored in cells in which cytosolic Na+ was increased and/or the Na+ gradient was decreased by reduction ... See full document
8
Proteolytic Processing at the Amino Terminus of Human Coronavirus 229E Gene 1-Encoded Polyproteins: Identification of a Papain-Like Proteinase and Its Substrate
... HCV 229E PCP1 is likely to be responsible for the genera- tion of the p9 ...be mediated by a homologous enzyme, HCV 229E ...HCV 229E ORF1a from codons 1 to 111 (DNA 4/5) to codons 1 to 2058 ... See full document
9
Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1
... HKU1 and SARS-CoV), a loose loop (IBV), and a tight loop (TGEV). Interestingly, the clustering of the secondary struc- ture correlates with the temporary classification of CoVs. We then explored the natural recognition ... See full document
9
Structural and functional characterization of MERS coronavirus papain-like protease
... protease (DUB), MERS-CoV PL pro is able to deubiquitinate interferon regulatory factor 3 (IRF3), which can prevent its nuclear translocation and suppress production of inter- feron β [10]. These studies support ... See full document
8
Comparative Host Gene Transcription by Microarray Analysis Early after Infection of the Huh7 Cell Line by Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus 229E
... Microarray analysis. Human genome-wide gene expression was examined with the GeneChip system HG-U133A microarray (Affymetrix Inc., Santa Clara, CA), which is composed of more than 22,000 oligonucleotide probe sets ... See full document
14
Endosomal Proteolysis by Cathepsins Is Necessary for Murine Coronavirus Mouse Hepatitis Virus Type 2 Spike-Mediated Entry
... Murine coronavirus mouse hepatitis virus (MHV) is the prototype of group II coronaviruses; the MHV strains used in this study infect primarily the liver and the brain and thus provide animal models for ... See full document
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