[PDF] Top 20 Quantitative proteomics in lung cancer
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Quantitative proteomics in lung cancer
... EGFR has become an important biological target for lung cancer. Inhibitors that target EGFR and block the signaling pathway have been developed and are clinically active [52]. Three EGFR inhibitors ... See full document
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Original Article Identification of novel proteins in chemoresistant lung cancer cells by quantitative proteomics
... Abstract: Lung cancer is the leading cause of cancer-related deaths worldwide, with a five-year survival rate of only ...cell lung cancer (NSCLC) in addition to large cell lung ... See full document
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Quantitative proteomics reveals molecular mechanism of gamabufotalin and its potential inhibition on Hsp90 in lung cancer
... a proteomics technique and bioinformatics analysis, 38 target-related proteins and the regulated network of CS-6 were ...for cancer therapy either by isolating from herbs or by modifying natural ... See full document
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Aberrant Mucin5B expression in lung adenocarcinomas detected by iTRAQ labeling quantitative proteomics and immunohistochemistry
... of lung adenocarcinoms and has been correlated with large tumor size, nodal metastasis and advanced tumor stage in NSCLC ...advanced lung cancer patients, overexpression of this protein has been ... See full document
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A novel method for sample preparation of fresh lung cancer tissue for proteomics analysis by tumor cell enrichment and removal of blood contaminants
... An alternative strategy to overcome at the experimen- tal level the contamination by inflammatory cells could be to add a separation step for example with the aid of antibody-coated magnetic beads targeting immunologi- ... See full document
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A quantitative immunoassay for lung cancer biomarker CIZ1b in patient plasma
... 65-70kDa cancer-specific epitope does indeed contain CIZ1b sequences, we adopted an epitope reconstitution ...to lung cancer patient ...65-70kDa cancer-specific species is very short, in the ... See full document
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Investigation of ovarian cancer associated sialylation changes in N-linked glycopeptides by quantitative proteomics
... of proteomics and glycomics technologies, the potential for the identi- fication of biomarkers has increased tremendously, in spite of the extreme complexity of the serum with a dy- namic range in concentration of ... See full document
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Aurora Kinase A expression is associated with lung cancer histological subtypes and with tumor de differentiation
... amplicons. Quantitative PCR (qPCR) was carried-out on an ABI PRISM 7900 HT Sequence Detection System (Applied Biosystems) in 384-well plates assembled by Biorobot 8000 (Qiagen, Germantown, ... See full document
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Quantitative Proteomics Analysis Identifies Mitochondria as Therapeutic Targets of Multidrug-Resistance in Ovarian Cancer
... (DOX), also known as adriamycin (ADR), is an an- thracycline antibiotic that is widely used as a chemo- therapeutic agent for the treatment of a variety of solid tumors, including ovarian cancer [2]. Previously ... See full document
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Quantitative proteomics analysis of differentially expressed proteins induced by astragaloside IV in cervical cancer cell invasion
... cervical cancer cell invasion by ...accurate quantitative values of these proteins by ...cervical cancer cells in the presence of ...of cancer [41], MGST3 increases in the LT97 adenoma cells ... See full document
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Integrated quantitative proteomic and transcriptomic analysis of lung tumor and control tissue: a lung cancer showcase
... cell lung cancer proteomes we observed 37 proteins only present in adenocarcinoma and 10 only present in ...in cancer tissue compared to controls (red data points in Figure ...only cancer ... See full document
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Quantitative proteomics signature profiling based on network contextualization
... There is some evidence in literature linking these complexes to renal cancer: For example, the 20S prote- asome is a potential biomarker for non-metastasized breast cancer [38]. A recent study in 2012 ... See full document
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Label free quantitative proteomics reveals the role of miR-200b in androgen-independent prostate cancer cells
... The MS data were analyzed using MaxQuant software version 1.3.0.5. MS data were searched against the uni- prot_human_152544_20160420.fasta (152544 total entries; downloaded April 20, 2016). An initial search was set at a ... See full document
11
Quantitative CT Indexes and CT Visual Score in Interstitial Lung Abnormality as Indicators of Concurrent Lung Cancer
... Our study had several limitations. It was retrospective and involved only surgic- al cases. Furthermore, we selected only those patients who had undergone thin-section CT of the whole lung for automatic analysis ... See full document
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Increased circulating resistin levels in early onset breast cancer patients of normal body mass index correlate with lymph node negative involvement and longer disease free survival: a multi center POSH cohort serum proteomics study
... Methods: Serum samples from EOBC patients (stages 1 – 3) were analysed using agnostic high-precision quantitative proteomics. Patients received anthracycline-based chemotherapy. The discovery cohort ( n = ... See full document
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Identification of lysine acetylome in cervical cancer by label-free quantitative proteomics
... cervical cancer tissues compared with adjacent normal tissues (Fold change > 2 and P < ...in cancer tissues or normal adjacent ...cervical cancer tissues were confirmed by immunoprecipitation ... See full document
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Comparative Proteomics Analysis of Exhaled Breath Condensate in Lung Cancer Patients
... monitoring lung inflammation, al- though others suggest that some EBC protein content may be derived from ambient air but this is unlikely to represent a significant ... See full document
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Label-free quantitative proteomics of CD133-positive liver cancer stem cells
... The IDEAL-Q method, which was developed previously [34], was utilized to process the LC-MS/MS data, and the Mascot search engine was used to extract the quantitative information. In brief, the raw data files were ... See full document
14
Quantitative proteomics for identifying biomarkers for Rabies
... Biological pathway analysis using canonical pathways suggests a significant perturbation in the pathways such as oxidative phosphorylation (7 proteins), tight junction signaling (7 proteins) and calcium signaling (6 ... See full document
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Interpretation and molecular validation of biomarker studies
... in cancer tissues; albeit at fi rst glance trivial to perform, immunohistochemical analysis can be aff ected by numerous parameters that can aff ect its ...breast cancer have been shown not to assign the ... See full document
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