[PDF] Top 20 <p>Randomized dose-finding study of batefenterol via dry powder inhaler in patients with COPD</p>
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<p>Randomized dose-finding study of batefenterol via dry powder inhaler in patients with COPD</p>
... administered via ELLIPTA-DPI for 42 days and both patients and physi- cians were blinded to treatment ...spirometry. Patients recorded the number of times rescue salbutamol was used over the last 24 ... See full document
15
Delivery characteristics and patients’ handling of two single-dose dry-powder inhalers used in COPD
... an inhaler should deliver doses consistently and be easy for patients to use with minimal ...characteristics, patients’ correct use, and preference of two single-dose dry powder ... See full document
11
Dose–response of an extrafine dry powder inhaler formulation of glycopyrronium bromide: randomized, double-blind, placebo-controlled, dose-ranging study (GlycoNEXT)
... delivery via the NEXThaler dry powder inhaler ...This study assessed the bronchodilator efficacy and safety of different doses of this formulation in patients with COPD to ... See full document
11
Patient preferences for dry powder inhaler attributes in asthma and chronic obstructive pulmonary disease in France: a discrete choice experiment
... the inhaler characteristics, but also on patients’ perception, satisfac- tion, and preference with the inhaler device [8, 9], as well as their competence in its use ...in patients with asthma ... See full document
11
Profile of fluticasone furoate/vilanterol dry powder inhaler combination therapy as a potential treatment for COPD
... stable COPD have shown that this combination therapy is well tolerated and produces a modest but statistically significant reduction in the number of severe exacerbations and improvement in FEV 1 , quality of ... See full document
8
Evaluating inhaler use technique in COPD patients
... this study also has some ...of inhaler devices, since it considers all steps recom- mended by manufacturers as a potential source of error, but reduces the subjectivity of grading the relevance of some ... See full document
8
<p>Choosing the right inhaler for your asthma or COPD patient</p>
... with inhaler use can be most evident in children and older ...inhalers, dry powder inhalers, and the soft mist ...each inhaler offers varying technical properties, a tailored and personalized ... See full document
12
In vitro dose comparison of Respimat<sup>®</sup> inhaler with dry powder inhalers for COPD maintenance therapy
... moderate COPD breathing pattern and 67% (SD 5%) for very severe COPD breathing ...nominal dose (ND) in vitro. This is in the range of 44%–63% in vivo in COPD patients who display large ... See full document
13
<p>Evidence-based review of data on the combination inhaler umeclidinium/vilanterol in patients with COPD</p>
... for COPD, once-daily, triple- drug, DPI (Trelegy Ellipta ® ) with UMEC/VI/ fl uticasone furoate (FF) ...in patients with COPD. 56,57 This large study with more than 10,000 patients with ... See full document
15
Asthma control in patients receiving inhaled corticosteroid and long acting beta2 agonist fixed combinations A real life study comparing dry powder inhalers and a pressurized metered dose inhaler extrafine formulation
... asthmatic patients [16]. However, in this study, the defi- nition of asthma control was established according to Zetterström [27] and was therefore different from the GINA guidelines, which is a limitation ... See full document
8
To Compare the Impact of Various Methods of Counseling about Inhalers in Asthma and Copd Patients and Measure the Effectiveness of Counseling
... limit patients’ ability to achieve optimal asthma outcomes and instruments to measure asthma control, and attempted to raise awareness that correct device use is crucial for successful ...a study of medical ... See full document
103
<p>A Delphi Consensus Document on the Use of Single-Inhaler Fixed-Dose Triple Therapies in COPD Patients</p>
... in patients with stable COPD to be covered with the document, a thematic index (annex) was de fi ned by the scienti fi c committee in a kick-off virtual meeting, held on September 20, ... See full document
11
<p>Efficacy And Safety Of Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler (GFF MDI) Formulated Using Co-Suspension Delivery Technology In Chinese Patients With COPD</p>
... PINNACLE-4 study evaluated the ef fi cacy and safety of GFF MDI in patients with moder- ate-to-very severe chronic obstructive pulmonary disease (COPD) from Asia, Europe, and the ...this ... See full document
14
Efficacy and safety of tiotropium Respimat<sup>®</sup> SMI in COPD in two 1-year randomized studies
... PGE, COPD symp- tom scores, PEFR, and rescue ...at study entry, center and treatment group, was performed on the PGR ...those patients with baseline and on-treat- ment data for at least one primary ... See full document
12
<p>Adherence to roflumilast under dose-escalation strategy in Korean patients with COPD</p>
... (OPTIMIZE study). In their trial, patients were randomized at a ratio of 1:1:1 into groups corresponding to a 4-week treatment of roflumilast 250 μ g once daily, 500 μ g every other day, or 500 μ g ... See full document
9
<p>Changes in COPD inhaler prescriptions in the United Kingdom, 2000 to 2016</p>
... of COPD patients in the United Kingdom, including the enthusiastic adoption of triple therapy, which appears to have replaced the inappropriate prescribing of ICS ...Kingdom’s COPD guidelines, but ... See full document
9
<p>A First-in-Human Dose Finding Study of Camrelizumab in Patients with Advanced or Metastatic Cancer in Australia</p>
... progressed. Patients were particularly concerned at their physical appear- ance if they received the highest doses of ...camrelizumab. Patients reported the lesions within the fi rst 10 weeks of starting ... See full document
13
<p>Inhaler technique errors in Romanian patients with asthma – a multicenter study</p>
... recorded inhaler technique errors, we adopted a within-subject ...present study design is that only fewer participants are required and the chance of discover- ing differences between the repeated ... See full document
14
<p>Long-Term Safety and Efficacy of Budesonide/Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler Formulated Using Co-Suspension Delivery Technology in Japanese Patients with COPD</p>
... Results: The safety population included 416 patients who received BGF MDI (n=139), GFF MDI (n=138), BFF MDI (n=70), or BUD/FORM DPI (n=69). Treatment-emergent AE (TEAE) rates were similar across treatment groups ... See full document
10
Inhalation drug delivery devices: technology update
... There are two types of nebulizers, jet and ultrasonic, that dif- fer in the force used to generate the aerosol from the respec- tive liquid. Depending on the model and the manufacturer, nebulizers generate 1–5 µ m ... See full document
9
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