[PDF] Top 20 RanGTPase: A Candidate for Myc Mediated Cancer Progression
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RanGTPase: A Candidate for Myc Mediated Cancer Progression
... a cancer therapeutic target has been described in recent stud- ies ...in cancer cell lines and tumor tis- sues at both the mRNA and protein levels compared with normal counterparts ...of cancer cells ... See full document
14
MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression
... of MYC-targeted genes and noncoding RNAs are also repressed by direct or indirect targeting by MYC [2, 3, ...by MYC, we analyzed the ENCODE database ...MYCLo-4, MYC is not shown to bind, ... See full document
10
MUC16-mediated activation of mTOR and c-MYC reprograms pancreatic cancer metabolism
... pancreatic cancer [38]. In case of ovarian cancer, MUC16/CA-125 is a well-established biomarker [39], and regulates cancer progression and metastasis ...which cancer cells fulfill their ... See full document
14
DNA Methylation Mediated Downregulation of miR-449c Controls Osteosarcoma Cell Cycle Progression by Directly Targeting Oncogene c-Myc
... cycle progression and apoptosis; moreover, c-Myc is usually overexpressed in different cancer types, such as liver, breast, lung and prostate cancers ...in cancer cells can result in ... See full document
13
Complex roles of filamin-A mediated cytoskeleton network in cancer progression
... from cancer patients, a correlation between filamin-A expression and drug sen- sitivity was observed, ...breast cancer cells to ionizing radiation ...sensitizes cancer cells to specific therapeutic ... See full document
12
KDM4B and KDM4A promote endometrial cancer progression by regulating androgen receptor, c-myc, and p27 kip1
... Enzymes that regulate reversible histone lysine methylation also might play an important role in EC [8]. One such family of enzymes is the KDM4 demethylases, which includes KDM4A-D (previously called JMJD2A-D). KDM4 ... See full document
19
Inhibition of β-Catenin signaling suppresses pancreatic tumor growth by disrupting nuclear β-Catenin/TCF-1 complex: Critical role of STAT-3
... pathway play an important role in many types of human cancers, including pancreatic cancer [2–4]. Mutation of β-catenin/APC or aberrant activation of Wnt and β-catenin signaling have been reported in ... See full document
14
CK2-mediated CCDC106 phosphorylation is required for p53 degradation in cancer progression
... By searching the BioGRID interaction database (https:// thebiogrid.org), we observed that CK2β had been identi- fied to be a potential interacting partner of the CCDC106 protein by high-throughput affinity-purification ... See full document
13
ANXA2 promotes esophageal cancer progression by activating MYC-HIF1A-VEGF axis
... Considering that VEGF is a well-described target gene of Hypoxia Inducible Factor 1 Alpha Subunit (HIF1A) [22], we further analyzed the influence of ANXA2 on the expression of HIF1A. Depletion of ANXA2 suppressed HIF1A ... See full document
13
TIMELESS contributes to the progression of breast cancer through activation of MYC
... 28]. MYC is identified as one of the four reprogram factors including Oct4, Sox2 and KLF4 that can dediffer- entiate fibroblasts to pluripotent stem cells [29, ...that MYC induces polycomb proteins Bmi-1 ... See full document
10
DYRK2 priming phosphorylation of c Jun and c Myc modulates cell cycle progression in human cancer cells
... human cancer cells, and this promo- tion was completely impeded by codeprivation of c-Jun or c-Myc in ...tumor progression through modulation of c-Jun and ... See full document
15
Pathobiology of cancer metastasis: a short account
... Dysregulation of the EMT programme contributes to tumour initiation, invasion and metastatic spread. Signal- ling pathways which induce EMT transitions include TGF-β, Notch, Wnt, and Hedgehog, and these in turn act via ... See full document
5
Triiodothyronine Attenuates Prostate Cancer Progression Mediated by β-Adrenergic Stimulation
... thyroid response (60). Tumor D1 activity was not measured, but previous studies have shown a direct correlation between enzyme activity (deiodination) and T3 generation in normal prostate tissue (35). T3 supplements also ... See full document
11
iTRAQ Identification of Candidate Serum Biomarkers Associated with Metastatic Progression of Human Prostate Cancer
... prostate cancer cells [14], and another study had reported that down-regulation of eEF1A1 by RNA interference (RNAi) in Du145 cells led to an inhibition of cell proliferation, invasion and migration ...prostate ... See full document
10
The HER2 inhibitor lapatinib potentiates doxorubicin-induced cardiotoxicity through iNOS signaling
... ng/mL) after a daily oral 1250 mg dose. At 72 h after treatment, hearts were harvested, digested and the isolated cardiomyocytes were stained with annexin V and 7-AAD (Figure 3A). We found that co-treatment of mice with ... See full document
13
The estrogen and c Myc target gene HSPC111 is over expressed in breast cancer and associated with poor patient outcome
... with Myc-specific small interfering (si)RNA (siMyc17), RISC-free (RF), or nontargeting (NT) siRNA con- trols, or mock transfected with no ...of MYC and HSPC111 mRNA were determined by quantitative real-time ... See full document
14
Original Article ZNF503 promotes colon cancer cell proliferation and mediates tumor progression via activating Myc
... sion of Myc, respectively, in both HCT116 and HT29 colon cancer cell-lines (Figure 4A and 4B). These results were further confirmed by luciferase reporter assay of overexpression of ZNF503 (Figure 4C). ChIP ... See full document
10
<p>LncRNA SNHG1 Regulates the Progression of Esophageal Squamous Cell Cancer by the miR-204/HOXC8 Axis</p>
... As shown in Figure 3A, starBase database predicted the complementary sequences of SNHG1 and miR-204 at posi- tion: chr11: 62620353-62620374. The wild-type and mutant luciferase reporter vectors (SNHG1-WT and SNHG1-MUT) ... See full document
11
Annexin A2-mediated cancer progression and therapeutic resistance in nasopharyngeal carcinoma
... From 2013, different research teams began to develop ANXA2-targeted therapy. C Ricciardelli’s team used an anti-ANXA2 antibody to reduce both tumor growth and metastasis in an ovarian cancer mice model (SK-OV3) ... See full document
10
Identification of Gcn1 binding proteins and characterization of their effect on Gcn2 function : a thesis submitted in partial fulfillment of the requirements for the degree Doctor of Philosophy in Biochemistry, Massey University, Albany, New Zealand
... Gcn2 is found in virtually all eukaryotes. In addition to the amino acid limitation it protects cells to a large array of stress conditions such as glucose and purine limitation, high salt, reactive oxygen species and UV ... See full document
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