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[PDF] Top 20 Regeneration of osteochondral defects using developmentally inspired cartilaginous templates

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Regeneration of osteochondral defects using developmentally inspired cartilaginous templates

Regeneration of osteochondral defects using developmentally inspired cartilaginous templates

... The osteochondral unit develops postnatally from a cartilaginous precursor that undergoes endochondral ossification during skeletal maturation ...(6,65). Inspired by this developmental process, ... See full document

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Hyaline Cartilage Regeneration on Osteochondral Defects by Intraarticular Injection of Human Peripheral Blood CD34+  Stem Cells, Hyaluronic Acid and Growth Factor In a Rat Model

Hyaline Cartilage Regeneration on Osteochondral Defects by Intraarticular Injection of Human Peripheral Blood CD34+ Stem Cells, Hyaluronic Acid and Growth Factor In a Rat Model

... suffers defects which cause pain, swelling, functional disturbances and disability, constituting a serious public health problem ...finally osteochondral defects on trochlear region of the knee joint ... See full document

10

Mechano regulation of stem cell differentiation and tissue regeneration in osteochondral defects

Mechano regulation of stem cell differentiation and tissue regeneration in osteochondral defects

... difficult to quantify. Wu et al. (2001) argued that under biological conditions, the fluid boundary conditions on the cartilage surface may vary from free flow to completely sealed, depending on the local stress/strain ... See full document

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Advancing osteochondral tissue engineering: bone morphogenetic protein, transforming growth factor, and fibroblast growth factor signaling drive ordered differentiation of periosteal cells resulting in stable cartilage and bone formation in vivo.

Advancing osteochondral tissue engineering: bone morphogenetic protein, transforming growth factor, and fibroblast growth factor signaling drive ordered differentiation of periosteal cells resulting in stable cartilage and bone formation in vivo.

... bone regeneration between con- ditions, especially in osteochondral defects treated with TGF-β1 aggregates where limited subchondral bone re- generation was ...[50]. Defects treated with TIs ... See full document

13

Pulsed electromagnetic fields after arthroscopic treatment for osteochondral defects of the talus: double blind randomized controlled multicenter trial

Pulsed electromagnetic fields after arthroscopic treatment for osteochondral defects of the talus: double blind randomized controlled multicenter trial

... A potential solution to obtain this goal is the application of pulsed electromagnetic fields (PEMFs). Bassett in the 1960s and 1970s introduced and improved the clinical use of this treatment modality [5,6]. Since then, ... See full document

10

Effects of osteochondral defect size on cartilage regeneration using a double network hydrogel

Effects of osteochondral defect size on cartilage regeneration using a double network hydrogel

... animal osteochondral defect models ...repair osteochondral defects by using the ar- tificially synthesized hydrogel without any cultured cells or mammalian-derived ...cartilage ... See full document

9

A Computational Model of Osteochondral Defect Repair Following Implantation of Stem Cell Laden Multiphase Scaffolds

A Computational Model of Osteochondral Defect Repair Following Implantation of Stem Cell Laden Multiphase Scaffolds

... an osteochondral defect treated with cell free versions of either the bilayer or trilayer ...promote regeneration of the damaged ...treat osteochondral defects ... See full document

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A preliminary study of osteochondral regeneration using a scaffold-free three-dimensional construct of porcine adipose tissue-derived mesenchymal stem cells

A preliminary study of osteochondral regeneration using a scaffold-free three-dimensional construct of porcine adipose tissue-derived mesenchymal stem cells

... of osteochondral defects in animal ...cylindrical osteochondral defect in each groove ...the osteochondral defect after 12 ...abundant cartilaginous white ...of osteochondral ... See full document

12

Osteochondral defects of the talus with a focus on platelet rich plasma as a potential treatment option: a review

Osteochondral defects of the talus with a focus on platelet rich plasma as a potential treatment option: a review

... treating osteochondral lesions of the ...with osteochondral lesions of the talus in terms of pain and functionality, although chondral regeneration via MRI is ... See full document

6

Mesenchymal stem cell-loaded porous tantalum integrated with biomimetic 3D collagen-based scaffold to repair large osteochondral defects in goats

Mesenchymal stem cell-loaded porous tantalum integrated with biomimetic 3D collagen-based scaffold to repair large osteochondral defects in goats

... for osteochondral repair has become one of the hot research fields ...in osteochondral defects in animal models ...upper cartilaginous layer of the scaffold is of lower strength and the ... See full document

17

Tissue specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues

Tissue specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues

... of osteochondral defects with control scaffolds or bi-layered AC-GP scaffolds after 6 and 12 months, respectively, and b) quantification of the macroscopic appearance of the defects based on repair ... See full document

62

Biofabrication of spatially organised tissues by directing the growth of cellular spheroids within 3D printed polymeric microchambers

Biofabrication of spatially organised tissues by directing the growth of cellular spheroids within 3D printed polymeric microchambers

... joint regeneration in skeletally mature rabbits 48 ...engineered cartilaginous tissues within, and in particular to determine (1) how the properties of the engineered cartilage varies through the depth of ... See full document

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Biomaterial based endochondral bone regeneration: A shift from traditional tissue engineering paradigms to developmentally inspired strategies

Biomaterial based endochondral bone regeneration: A shift from traditional tissue engineering paradigms to developmentally inspired strategies

... processed using manufacturing techniques such as lyophilization to generate highly porous scaffolds, the porosity of which can be regulated by varying the final freeze-drying temperature of the process ...bone ... See full document

13

How reliable is MRI in diagnosing cartilaginous lesions in patients with first and recurrent lateral patellar dislocations?

How reliable is MRI in diagnosing cartilaginous lesions in patients with first and recurrent lateral patellar dislocations?

... The average time interval between acute LPD and MRI examination was 4.7 days (range, 0-19 days). All patients underwent standardized MR imaging on a 1.5-Tesla scan- ner (Siemens Magnetom Avanto syngo MR B 15, Erlan- gen, ... See full document

8

Effects of tranexamic acid on the recovery of osteochondral defects treated by microfracture and acellular matrix scaffold: an experimental study

Effects of tranexamic acid on the recovery of osteochondral defects treated by microfracture and acellular matrix scaffold: an experimental study

... cylindrical defects having a width of 4 mm and depth of 5 mm were created in the weight-bearing surfaces of the medial and lateral condyles of the right ... See full document

8

The role of oxygen as a regulator of stem cell fate during the spontaneous repair of osteochondral defects

The role of oxygen as a regulator of stem cell fate during the spontaneous repair of osteochondral defects

... tion using a random function, rather than with a strain dependent algorithm, 17 had only a small effect on the predicted outcome of tissue formation (Supple- mentary Text ...an osteochondral defect, the ... See full document

16

Towards 3D bioprinting of anatomically accurate, mechanically reinforced cartilage templates for biological joint resurfacing

Towards 3D bioprinting of anatomically accurate, mechanically reinforced cartilage templates for biological joint resurfacing

... reinforced using 3D printed thermoplastics, specifically PLA, PLGA 65:35, PLGA 85:15 and PCL, to generate composite constructs capable of supporting robust ...cartilage templates were engineered ... See full document

192

Polymeric hydrogels for burn wound care: Advanced skin wound dressings and regenerative templates

Polymeric hydrogels for burn wound care: Advanced skin wound dressings and regenerative templates

... Remarkably, while porous collagen and alginate scaffolds were found to impede re-epithelialization and increase the inflammatory response, alginate hydrogels did not elicit sim- ilar responses and appeared to be much ... See full document

9

Biomimetic intrafibrillar mineralized collagen promotes bone regeneration via activation of the Wnt signaling pathway

Biomimetic intrafibrillar mineralized collagen promotes bone regeneration via activation of the Wnt signaling pathway

... bone regeneration identified by transcriptional analysis were veri- fied both in vivo through immunohistochemical analysis and in vitro by quantitative real-time transcription polymerase chain reaction ... See full document

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Spontaneous hyaline cartilage regeneration can be induced in an osteochondral defect created in the femoral condyle using a novel double network hydrogel

Spontaneous hyaline cartilage regeneration can be induced in an osteochondral defect created in the femoral condyle using a novel double network hydrogel

... tissue regeneration by the DN gel ...large osteochondral defect by means of implanting a cylindrical PAMPS/PDMAAm DN gel plug at the bottom of the ... See full document

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