[PDF] Top 20 Down regulation of cell surface CXCR4 by HIV 1
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Down regulation of cell surface CXCR4 by HIV 1
... with HIV-1 LA1 at a MOI of 4 or ...human CXCR4 followed by fluorescein isothiocyanate (FITC)- conjugated goat anti-mouse immunoglobulin G ...antibody. CXCR4 monoclonal antibody 12G5 derived by ... See full document
10
Expression of Nef from unintegrated HIV 1 DNA downregulates cell surface CXCR4 and CCR5 on T lymphocytes
... An important consideration is that patterns of tran- scription and translation from unintegrated virus, arising from D116N integrase mutations or INSTI-treated cells, are identical to those observed in infections of ... See full document
10
Regulation of Ccr5 ise on Primary Cd4+ Lymphocytes by R5X4 HIV-1
... molecular surface of monomeric gp120 core showing the inner domain (left side) and the heavily glycosylated outer domain (right side), which is modeled with complex (light blue) or high-mannose (dark blue) ... See full document
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Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance
... if down regulation of CCR5 and CXCR4 coreceptors conferred viral resistance, siRNA transgenic GHOST-R3/X4/R5 cells were challenged with X4-tropic (NL4-3), R5-tropic (BaL-1) and dual coreceptor ... See full document
9
HIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vector
... that down regulating either CXCR4 or CCR5 will protect cells from X4 or R5 HIV-1 strains respectively at the level of viral entry ...study, down reg- ulating CCR5 alone in the face of ... See full document
12
Distinct Functional Sites for Human Immunodeficiency Virus Type 1 and Stromal Cell-Derived Factor 1α on CXCR4 Transmembrane Helical Domains
... receptor CXCR4, a mem- ber of the superfamily of G-protein-coupled receptors (GPCRs) possessing seven transmembrane (TM) helical do- mains, specifically binds the CXC chemokine stromal cell-de- rived factor ... See full document
7
Different Effects of Nef-Mediated HLA Class I Down-Regulation on Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Cytolytic Activity and Cytokine Production
... experiments, surface expression of HLA class I molecules on HIV-1-infected cells was ...11 1 M) following by staining with fluorescein isothiocyanate-labeled anti-mouse immunoglobulin (Silenus ... See full document
9
The Promiscuous CC Chemokine Receptor D6 Is a Functional Coreceptor for Primary Isolates of Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 on Astrocytes
... the cell biology of D6; its lack of G protein signaling and its constitutive endosomal recycling mean that ligand-induced surface down-regulation is much harder to achieve ...D6 surface ... See full document
7
Identification of a Subset of Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus Strains Able To Exploit an Alternative Coreceptor on Untransformed Human Brain and Lymphoid Cells
... indicator cell lines in vitro. Many HIV-2 and SIV strains are particularly promiscuous for different coreceptors in such assays; however, HIV-1 strains can also use a variety of alternative ... See full document
15
A genotypic method for determining HIV 2 coreceptor usage enables epidemiological studies and clinical decision support
... engineered cell lines enable the detection of a broad range of core- ceptor usage patterns, such assays are expensive, time- consuming, and their interpretation can be ...TZM-bl cell based assays using ... See full document
16
Autophagy is involved in T cell death after binding of HIV 1 envelope proteins to CXCR4
... with 1 μM Rapa and examined by ...target cell sections were analyzed from at least 100 randomly chosen TEM fields by 2 ...bars: 1 μm; 250 nm (indicated ... See full document
13
Natural Alpha Interferon-Producing Cells Respond to Human Immunodeficiency Virus Type 1 with Alpha Interferon Production and Maturation into Dendritic Cells
... of HIV-1 on the survival of FIG. 2. Expression of HIV-1 coreceptors and DC-SIGN on ...for CXCR4, CCR5, and DC-SIGN by RT- PCR in blood DC ...by cell sorting to the purity of ... See full document
8
Inhibitory Mechanism of the CXCR4 Antagonist T22 against Human Immunodeficiency Virus Type 1 Infection
... of HIV-1, including primary isolates, but not of non-T-tropic strains in PHA-stimulated PBMC (Table ...(Fig. 1). We also showed that T22 interfered with SDF-1␣–CXCR4 inter- actions ... See full document
9
Unique Ligand Binding Sites on CXCR4 Probed by a Chemical Biology Approach: Implications for the Design of Selective Human Immunodeficiency Virus Type 1 Inhibitors
... inhibit HIV-1 infection (4, 13) by blocking HIV-1 gp120 bind- ing sites (2, 14) and/or inducing receptor internalization (1, ...for CXCR4 or CCR5 by modifying the N-terminal ... See full document
7
Alternative Coreceptor Requirements for Efficient CCR5- and CXCR4-Mediated HIV-1 Entry into Macrophages
... sequences of the six CXCR4-using Envs to better understand Env determinants that may contribute to efficient CXCR4- mediated HIV-1 entry into macrophages. Sequence analysis identified amino ... See full document
11
Primary Human Immunodeficiency Virus Type 2 (HIV-2) Isolates Infect CD4-Negative Cells via CCR5 and CXCR4: Comparison with HIV-1 and Simian Immunodeficiency Virus and Relevance to Cell Tropism In Vivo
... use CXCR4 (MIL and ...U87/CD4 cell lines that individually express CCR1, CCR2b, CCR3, CCR5, and CXCR4 (6, ...GHOST/CD4/coreceptor cell lines (10) or CCC/CD4 cells transfected with and tran- ... See full document
10
Original Article Estrogen receptor ESR1 promotes BMSCs cell proliferation and migration via regulation of SDF-1/CXCR4 signaling
... Healthy 3-4 week SPF grade SD rats weighing 100-120 g were sacrificed by cervical disloca- tion, soaked in 75% ethanol for 10 min and then the femur and tibia were isolated under sterile condition. Samples were immersed ... See full document
8
The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef.
... HPB-ALL and HuT-78 human CD4+ T cells and the CD4+ human monocyte/macrophage line U937 transduced with LNefSN or the control vector LN were analyzed for CD4 and p56lck expression.. Figur[r] ... See full document
10
Unique Monoclonal Antibody Recognizing the Third Extracellular Loop of CXCR4 Induces Lymphocyte Agglutination and Enhances Human Immunodeficiency Virus Type 1-Mediated Syncytium Formation and Productive Infection
... of CXCR4 utilization in human immunodeficiency virus type 1 (HIV-1) infection, a new generation of three monoclonal antibodies (MAbs) was developed in WKA ...of CXCR4, has unique ... See full document
10
Targeted infection of HIV 1 Env expressing cells by HIV(CD4/CXCR4) vectors reveals a potential new rationale for HIV 1 mediated down modulation of CD4
... the HIV-1 packaging construct, several deletions were introduced into pNL4-3 (1) DNA by ...defective HIV-1-Neo construct has previously been described ...and HIV-1-Neo ... See full document
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