[PDF] Top 20 Rituximab in early systemic sclerosis
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Rituximab in early systemic sclerosis
... However, unfortunately, the trial had major recruit- ment problems. In a time span of nearly 4 years, 17 patients had been included in the trial. Based on this low inclusion rate, the METC advised to prematurely end ... See full document
11
<p>Epidemiology of systemic sclerosis and systemic sclerosis-associated interstitial lung disease</p>
... Organ involvement occurs early in the course of the disease. 9 The occurrence of associated complications is related to the severity and progressiveness of disease, with approximately 25% of the patients ... See full document
17
Early systemic sclerosis: marker autoantibodies and videocapillaroscopy patterns are each associated with distinct clinical, functional and cellular activation markers
... Various attempts have been made to find a correct clas- sification for these patients who do not meet the prelimin- ary 1990 American College of Rheumatology (ACR) SSc criteria [5] in order to foster their inclusion in ... See full document
10
Cross sectional study of soluble selectins, fractions of circulating microparticles and their relationship to lung and skin involvement in systemic sclerosis
... cutaneous sclerosis, which indicated that the pa- tients in this study were well into the disease ...or early SSc, which could have had implications for the results ... See full document
9
<p>Interstitial Lung Disease in Systemic Sclerosis: Focus on Early Detection and Intervention</p>
... with early diffuse SSc (nine of whom had lung involvement), patients who completed a year of treatment with low-dose intravenous pulse CYC received 1 year of treatment with AZA (50 mg/day for the fi rst 20 days and ... See full document
25
Early atherosclerosis in systemic sclerosis and its relation to disease or traditional risk factors
... neous systemic sclerosis (dcSSc) subtype was present in these studies compared with our study, although Kaloudi and colleagues [23] found no significant differences between mean IMT between ... See full document
8
Cartilage oligomeric matrix protein induced complement activation in systemic sclerosis
... in early disease have in addition been shown to predict mortality in SSc, possibly explained by the more frequent and severe internal organ involvement in patients with dcSSc ... See full document
8
Comprehensive Analysis of 20 Cases of Systemic Sclerosis
... Scleroderma renal crisis is a medical emergency, the outcome is mainly determined by the extent of renal damage at the time of initiation of treatment. Prompt recognition of early or impending scleroderma renal ... See full document
151
Therapeutic targets in systemic sclerosis
... the early events in SSc ...of early dcSSc fibroblasts expresses the CCL2 receptor, and so the potential for autocrine or paracrine stimulation of fibroblasts in SSc is ... See full document
5
Clinical Profile of Systemic Sclerosis
... occurs early and is followed by proliferation of intima and smooth muscle cells with deposition of matrix and perivascular fibrosis leading to narrowing of the lumen and eventual obliteration of the ... See full document
81
Systemic sclerosis sine scleroderma
... Skin involvement is considered a cardinal feature of systemic sclerosis, and the name “scleroderma” means hardening of the skin. Cutaneous manifestations are also crucial in the initial diagnosis. Although ... See full document
6
Stress Doppler echocardiography for early detection of systemic sclerosis associated pulmonary arterial hypertension
... for early manifest PAH in SSc if the assessment is ...an early treatment with PH-targeted therapy might at- tenuate PASP increase in patients with borderline PH in SSc ...of early treatment in SSc- ... See full document
11
Pressure and pain In Systemic sclerosis/Scleroderma - an evaluation of a simple intervention (PISCES): randomised controlled trial protocol
... the trial to stream potentially suitable patients into early trial clinics. Alternatively, patients identified by other means such as waiting lists or upon review of case records, will receive a letter and the ... See full document
8
Pressure and pain In Systemic sclerosis/Scleroderma an evaluation of a simple intervention (PISCES): randomised controlled trial protocol
... the trial to stream potentially suitable patients into early trial clinics. Alternatively, patients identified by other means such as waiting lists or upon review of case records, will receive a letter and the ... See full document
8
Early systemic sclerosis: short term disease evolution and factors predicting the development of new manifestations of organ involvement
... skin sclerosis, digital ulcers/scars, two or more teleangectasias, clinically visible nailfold capillaries, cutaneous calcinosis, X-ray bibasilar lung fibrosis, X-ray esophageal dysmoti- lity, ECG signs of ... See full document
8
Anti-collagen type v: a marker of early systemic sclerosis?
... This is the first study measuring anti-collagen type V in patients with early SSc. The previous work assessing anti-collagen antibodies evaluated several types of anti-collagen antibodies (I, II, III, IV and V) in ... See full document
5
Hit hard and early: analysing the effects of high dose methylprednisolone on nailfold capillary changes and biomarkers in very early systemic sclerosis: study protocol for a 12 week randomised controlled trial
... the nailfold capillaries in SSc has not been extensively stud- ied. The most successful treatment of progressive SSc to date involved an autologous haematopoietic stem cell trans- plantation (ASCT), after which ... See full document
6
Echocardiography may help detect pulmonary vasculopathy in the early stages of pulmonary artery hypertension associated with systemic sclerosis
... SS: Systemic Sclerosis; TAPSE: Tricuspid annular plane systolic excursion; TLC: Total Lung Capacity; VAS: -Visual analogic Scale; VO2: Oxygen Consumption; VCO2: Carbon Dioxide production; VE/VCO2 slope: CO2 ... See full document
6
Quality of life as measured by the short-form 36 (SF-36) questionnaire in patients with early systemic sclerosis and undifferentiated connective tissue disease
... chronic conditions as heart and lung diseases, diabetes and arterial hypertension [7]. Previous studies that in- vestigated HRQOL in patients with SSc were based on patients who fulfilled either the American College of ... See full document
6
A Study of Cardio Pulmonary Manifestations in Systemic Sclerosis
... Xerostomia, reduced oral aperture, periodontal disease and resorption of the mandibular condyles are frequent. The frenulum of the tongue may be shortened. Symptoms of gastroesophageal reflux disease (GERD) develop ... See full document
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