[PDF] Top 20 Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection.
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Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection.
... the role of the highly basic region of HIV-1 MA in the virus life cycle, particularly with respect to macrophage infection, we introduced a series of single- and ... See full document
6
Human Immunodeficiency Virus Type 1 Gag Polyprotein Multimerization Requires the Nucleocapsid Domain and RNA and Is Promoted by the Capsid-Dimer Interface and the Basic Region of Matrix Protein
... The human immunodeficiency virus type 1 (HIV-1) Gag polyprotein directs the formation of virions from productively infected ...RNA-binding domain of Gag, exhibited ... See full document
14
Role of the matrix protein in the virion association of the human immunodeficiency virus type 1 envelope glycoprotein.
... To determine whether the amino acid changes in the MA protein domain that abolish virus replication affect viral particle assembly or release, the mutant proviruses were transfected into[r] ... See full document
8
Role of a Putative gp41 Dimerization Domain in Human Immunodeficiency Virus Type 1 Membrane Fusion
... natural human infection ...dimerization domain of gp41 and present the ...this domain. We characterize the role of this an- tiparallel two-stranded coiled-coil structure in NAb ... See full document
9
Human Immunodeficiency Virus Type 1 Capsid Mutation N74D Alters Cyclophilin A Dependence and Impairs Macrophage Infection
... Mutations in HIV-1 CA, or other retroviral CAs, can overcome CPSF6-358 restriction (15), supporting the argument that CA has a role in the nuclear import of preintegration complexes. One such CA mutant, ... See full document
7
Role of Complex Carbohydrates in Human Immunodeficiency Virus Type 1 Infection and Resistance to Antibody Neutralization
... outer domain of HIV-1 gp120, ostensibly forming a protective “fence” against ...a human cell line lacking N- acetylglucosamine transferase I (GnTI), the enzyme that initiates the conversion of ... See full document
19
Potential Role for CD63 in CCR5-Mediated Human Immunodeficiency Virus Type 1 Infection of Macrophages
... HIV-1 infection of primary monocyte-derived ...HIV-1 infection of macrophages, we screened a myeloid MAb library (n ⫽ 120) for antibodies which showed increases in binding ...HIV-1 ... See full document
10
Macrophage tropic variants initiate human immunodeficiency virus type 1 infection after sexual, parenteral, and vertical transmission
... of infection and may be responsible for establishing infection in an individual exposed to the mixture of HIV-1 ...of virus populations, present in sexual, parenteral, or vertical ... See full document
9
Role of Matrix in an Early Postentry Step in the Human Immunodeficiency Virus Type 1 Life Cycle
... MA basic domain (24), we noted that a nonbasic residue within this region, the Leu at MA amino acid 20, is remarkably well conserved among lentiviral MA proteins ...impairing virus assembly and ... See full document
11
Matrix and Envelope Coevolution Revealed in a Patient Monitored since Primary Infection with Human Immunodeficiency Virus Type 1
... productive infection in ...into virus particles and provided an explanation for the impair- ment of ...LLP-1 domain, resulted from a defect in Env incorporation into virions (28, 32, 43, ... See full document
15
Macrophage tropism of human immunodeficiency virus type 1 and utilization of the CC-CKR5 coreceptor.
... of infection of CD4 1 nonlymphoid cells by some strains of HIV-1 (14, 30, ...both macrophage- tropic viruses, preferentially utilize the CC-CKR5 coreceptor for entry, whereas the dual-tropic ... See full document
5
Cyclophilin A, TRIM5, and Resistance to Human Immunodeficiency Virus Type 1 Infection
... CypA domain of owl monkey TRIMCyp and the similarly placed SPRY domain of TRIM5 ␣ ...SPRY domain is more complex than a simple protein-protein ...glutathione matrix and used to pull out the CA ... See full document
8
Nef Enhances Human Immunodeficiency Virus Type 1 Infectivity in the Absence of Matrix
... core domain (22). This globular domain contains a basic surface patch thought to interact with acidic phospholipids and represents the portion of MA that is structurally conserved among distantly ... See full document
6
Differential membrane binding of the human immunodeficiency virus type 1 matrix protein.
... the basic domain are required for efficient membrane ...the basic domain forms an amphipathic b sheet exposed on the surface of the ... See full document
9
Binding of Human Immunodeficiency Virus Type 1 Gag to Membrane: Role of the Matrix Amino Terminus
... MA domain is modified by the covalent attachment of a myr- istic acid ...and virus assembly has been defin- itively established (4, 8, 19, 23, 39, 41, 43, 49); however, the contribution of other MA domains ... See full document
9
Role of the Gag Matrix Domain in Targeting Human Immunodeficiency Virus Type 1 Assembly
... Fluorescent staining and confocal microscopy. Fluorescent staining of trans- fected HeLa cells with antibodies and lectins was performed as described pre- viously (47), with some modifications. Briefly, cells were grown ... See full document
12
Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo.
... The V3 envelope domain was also found to be capable of conferring macrophage infection upon NLHX when derived from uncultured polymerase chain reaction clones from brain [NLHXw1-lclBgpj [r] ... See full document
6
A role for urokinase-type plasminogen activator in human immunodeficiency virus type 1 infection of macrophages.
... of human immunodeficiency virus type 1 (HIV-1) IIIB and MN strains, as well as a synthetic, cyclized peptide representing the clade B consensus sequence of ...the ... See full document
6
Role of the Membrane-Spanning Domain of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein in Cell-Cell Fusion and Virus Infection
... single-round infection could be at a postentry ...which virus infection was ...decreased virus- cell fusion by approximately 92% compared to WT, but rein- troduction of GGXXG motif increased ... See full document
12
Functional Characterization of the Human Immunodeficiency Virus Type 1 Nef Acidic Domain
... Although it appears unlikely that the four-glutamate Nef AC (6, 13) functions as a decisive structural element for Nef to bind PACS-1 in the manner of the furin AC, we considered the possibility that the structure ... See full document
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