[PDF] Top 20 The role of bisphosphonates in breast cancer: Development of bisphosphonates

... Abstract Bisphosphonates are synthetic compounds characterized by a P–C–P group, and are thus analogs of inorganic ...that bisphosphonates have biological ...other bisphosphonates are incorporated ... See full document

... human breast cancer cell line, MCF-7, has been shown to produce osteoblastic or mixed osteolytic and osteoblastic bone lesions following intracardiac inoculation in a nude mouse ...with ... See full document

... resorption, bisphosphonates have also been shown to exhibit antitumour ...vitro, bisphosphonates inhibit proliferation and induce apoptosis in cultured human breast cancer ...with ... See full document

... important role in reducing skeletal-related events, in reducing bone pain and in associated analgesic use, as well as improving quality of ...life. Bisphosphonates should therefore now be considered as ... See full document

... of breast cancer goes far beyond the traditional pathological staging and grading systems, as evidenced by the great variation in clinical ...the development of drugs that antagonise the binding of ... See full document

... of bisphosphonates from pre-clinical studies, supporting a role for these drugs beyond their traditional use in treatment of cancer-induced bone ...erent bisphosphonates on tumour growth, both ... See full document

... of bisphosphonates from pre-clinical studies, supporting a role for these drugs beyond their traditional use in treatment of cancer-induced bone ...erent bisphosphonates on tumour growth, both ... See full document

... Interestingly, reductions in bone recurrence and BC deaths occurred regardless of ER status, nodal status, type of BP, and whether or not women received chemother- apy. The impact on survival and fracture rates for the ... See full document

... Other approaches to MMP inhibition Although synthetic inhibitors of MMPs have so far proved to be ineffective, there are several alternative approaches that can be considered. Much research is being directed towards the ... See full document

... of bisphosphonates The principal biologic effect of bisphosphonates is to inhibit osteoclastic bone resorption; these agents may impede both the development of bone metastases and the survival of ... See full document

... Abstract: Bisphosphonates inhibit osteoclast-mediated bone resorption, thereby inhibiting the release of growth factors necessary to promote cancer cell growth, differentiation, and tumor formation in ... See full document

... that bisphosphonates may render the bone a less favorable microenvironment for tumor growth by reducing osteoclast-mediated bone resorption, we used a continu- ous or frequent intermittent low-dose therapy with ... See full document

... Most of BRONJ patients were diagnosed with multiple myeloma, breast cancer, and prostate cancer. Furthermore, they were all injected with Nitrogen-containing BPs and steroids, such as dexamethasone ... See full document

... of bisphosphonates. This review will focus in detail on the role of tumour associated macrophages in breast cancer progression, the actions of bisphosphonates on macrophages in vitro ... See full document

... the development of osteonecrosis of the jaw with zoledronic acid compared to pamidronate, patients may prefer pamidronate to zoledronic acid until more data become available on this adverse effect of ... See full document

... Discussion Breast cancer is one of the most common malignancies in ...underlying breast cancer has led to significant scientific breakthroughs and the development of new therapeutic ... See full document

... To complete these studies, we measured the levels of a panel of cytokines and growth factors in patient serum and bone marrow before and three days after intravenous bisp[r] ... See full document

... In premenopausal women diagnosed with breast cancer, systemic treatment can induce a secondary loss of ovarian function (e.g. after chemotherapy) or may directly suppress ovarian function by hormonal ... See full document

... of bisphosphonates on skeletal metastases is not solely due to their action on bone ...with breast cancer by bis- phosphonates, their effect is incomplete and dose dependent ...of breast ... See full document

... prostate cancer will develop bone metastases, which have a substantial impact on quality of ...prostate cancer (CRPC) and bone metastases, the treatment landscape has evolved rapidly over the past few ... See full document