[PDF] Top 20 Role of Calpain in Pathogenesis of Human Disease Processes
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Role of Calpain in Pathogenesis of Human Disease Processes
... of calpain 1 by angiotensin II induces matrix metalloproteinase type 2 activity which has been linked to extracellular matrix remodeling by promoting collagen I and III production and inducing vascular ... See full document
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Bcr-abl regulates Stat5 through Shp2, the interferon consensus sequence binding protein (Icsbp/Irf8), growth arrest specific 2 (Gas2) and calpain
... the role of Calpain in the pathogenesis of CML, we first determined the mechanism for increased expression of the calpain inhibitor Gas2 in Bcr-abl expressing ... See full document
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Calpain activation impairs neuromuscular transmission in a mouse model of the slow channel myasthenic syndrome
... the role of the calcium-acti- vated protease calpain in the pathogenesis of synaptic dysfunction in ...fluorogenic calpain substrate was increased at the NMJ of dissociated muscle ...of ... See full document
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Role of thiamine in Huntington’s disease pathogenesis: In vitro studies
... of human B lymphocytes with CAG ex- panded huntingtin gene and normal cells through the studies on the following items: (1) determination of the supplemented thiamine concentrations that are ef- fective for cell ... See full document
10
The role of exosomes in the pathogenesis of Alzheimer’ disease
... In addition to proteins and lipids, genetic materials are also found in exosomes, such as DNA, mRNA, miRNA, ribosomal RNA (rRNA), circular RNA, and long non- coding RNA (lnRNA) [37–42]. Among them, small RNA (<30 ... See full document
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The role of PHD2 mutations in the pathogenesis of erythrocytosis
... not redundant, such that loss of PHD2 function could not be compensated for by PHD1 or PHD3, and the EPO pathway is sensitive to modest changes in PHD2 activity, such that even a heterozygous PHD2 mutation was sufficient ... See full document
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Roles of calpain-calpastatin system (CCS) in human T cell activation
... The calpain-calpastatin system (CCS) has long been recognized as participating in multiple intracellular processes, including apoptosis, movement, and proliferation (reviewed in [1, 16]), which makes it an ... See full document
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<p>Role of Monocytes/Macrophages in Covid-19 Pathogenesis: Implications for Therapy</p>
... a human monoclonal antibody that inhibits human GM-CSF receptor (GM-CSF-R) and is also an investigational drug for the treatment of rheumatic diseases 79 Also, very recently, mavrilimumab treatment has ... See full document
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Generation of leukotrienes by purified human lung mast cells
... central role in the pathogenesis of human allergic disease, biochemical studies have been restricted to rat peritoneal mast cells and basophilic leukemia cells because they could be easily ... See full document
6
Pathogenesis of Alzheimer's Disease: Role of Amyloid-beta and Hyperphosphorylated Tau Protein
... Transcription and translation processes are required for expression of polypeptide gene products that generate mRNA and synthesize polypeptide chains, respectively. It is known that some important amino acid ... See full document
11
Original Article Expression of transforming growth factor-β in mast cells in human chronic periapical diseases
... of human periapical ...important role in the pathogenesis of human chronic periapical diseases, particu- larly in the formation of fibrous tissues in periapical ... See full document
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The role of rasagiline in the treatment of Parkinson’s disease
... A total of 404 subjects with early PD were randomized to receive placebo, rasagiline 1 mg/day, or rasagiline 2 mg/day. Subjects had to be over age 35 with at least 2 cardinal signs of PD and disease severity of ... See full document
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Protein Aggregation in the Brain: The Molecular Basis for Alzheimer’s and Parkinson’s Diseases
... Alzheimer’s disease), this strategy could well be counterproductive, as it might shift the equilibrium of aggrega- tion away from fibrils to more haz- ardous oligomeric ...Alzheimer’s disease therapy dis- ... See full document
14
Role of berberine in Alzheimer’s disease
... exact role of berberine in the oxidative stress in AD remains ...the pathogenesis of AD involved in oxidative damage is not well ...the pathogenesis of AD involved in oxidative ... See full document
12
Autism: Synthetic- and plant-derived control and treatment
... Autism is a complex neurobehavioral condition that includes impaired social interactions, verbal development, and communication skills associated with repeated and difficult behaviors. Due to the wide range of symptoms ... See full document
7
Pathogenesis and management of postprandial hyperglycemia: role of incretin-based therapies
... the pathogenesis of postprandial hyperglycemia, the mechanisms by which GLP-1 receptor agonists and DPP-4 inhibitors reduce postprandial plasma glucose concentrations, and the results of recent clinical trials ... See full document
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The Role of Smart Sensors in Production Processes and the Implementation of Industry 4.0 | Journal of Engineering Sciences
... The application of smart sensors in production pro- cesses has been greatly simplified through the standardi- zation of process data and the latest developments of IO- Link devices with regard to self-interface and ... See full document
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Oxygen, oxidative stress, hypoxia, and heart failure
... cal role of ATII in the development and progression of heart fail- ure is now well established, and blocking either ATII generation or ATII binding to the AT1 receptor prolongs life in specific patient ... See full document
10
Role of the extracellular matrix and growth factors in skull morphogenesis and in the pathogenesis of craniosynostosis
... significant role in skull morphogenetic events is played by signal molecules present in the early embryo in ...in human cleft palate cells in vitro (Bodo et ...a role for TGFβ isoforms in the biology ... See full document
9
Role of ICAM-1 and E-selectin gene polymorphisms in pathogenesis of PAOD in Egyptian patients
... The demographic data of all the studied groups are illustrated in Table 2. With regards to the risk factors of smoking, hypertension, and ischemic heart disease (IHD), there was a statistically significant ... See full document
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