[PDF] Top 20 Role of CTR4 in the Virulence of Cryptococcus neoformans

... a CTR4-dependent growth defect was also exhibited under higher copper concentrations ...that CTR4 deletion resulted in an increase in cellular copper quota that was exacerbated by higher copper ... See full document

... important role in the secretion, localization, and function of many proteins, as well as in cell wall integrity and morphogenesis in ...pathogen Cryptococcus neoformans. Disruption of the C. ... See full document

... Cryptococcus neoformans is an opportunistic yeast responsible for lethal meningoencephalitis in humans. This pathogen elabo- rates a polysaccharide capsule, which is its major virulence factor. ... See full document

... the virulence of many pathogenic microbes, and iron limitation is an important defense mechanism for mammalian ...pathogen Cryptococcus neoformans, and here, we characterize the roles of the ... See full document

... Inositol transporters are differentially expressed under dif- ferent culture conditions. To understand how the Itrs are in- volved in inositol sensing and transport, quantitative real-time PCR (qRT-PCR) was performed to ... See full document

... C. neoformans allowed for analysis of the role of copper homeostasis during fungal ...and virulence factor defects. More interestingly, virulence of the cuf1Δ deletion strain was attenuated ... See full document

... C. neoformans can regulate the overall organization of the cap- sule, which is mainly composed of two polysaccharides, GXM and galactoxylomannan, which make up ⬃90 and 7%, respec- tively, of the capsular ...C. ... See full document

... C. albicans is a major opportunistic human fungal pathogen and can cause infec- tions in immunocompromised persons that range from superficial infections of the skin and mucosal surfaces to life-threatening systemic ... See full document

... overall virulence of a ...cryptococcal virulence adapta- tion genes will be identified by using additional animal models and cryptococcal ...other virulence adaptation ...a role for ... See full document

... for virulence and survival in the host. In Cryptococcus neoformans, an op- portunistic pathogen of humans, the acidic monosaccharide glucuronic acid (GlcA) is a critical component of multiple ... See full document

... in virulence in multiple fungi, as with the association between virulence and increased mitochondrial fusion in Cryptococcus ...in Cryptococcus neoformans, a related opportunistic ...C. ... See full document

... in Cryptococcus neoformans plays an important role in fungal dissemination to the brain and causing menin- ...C. neoformans resemble those of plants more than those of ... See full document

... ABSTRACT Cryptococcus neoformans is a human fungal pathogen and a major cause of fungal meningitis in immunocompro- mised ...C. neoformans but exert a fungistatic effect, necessitating long treatment ... See full document

... C. neoformans FHB1 gene was identified by se- quence similarity to the ...a role in resistance to nitric oxide, survival in macro- phages, and full virulence in mice ... See full document

... C. neoformans and studied whether phagocytosis would be affected by the absence of ...C. neoformans increased when App1 protein was absent (Figure ...C. neoformans is primarily mediated through ... See full document

... Why Cryptococcus neoformans has this remarkable tropism for the CNS is not ...C. neoformans revealed a predominantly transcellular migration of cryptococci across the brain endothelium; however, the ... See full document

... The role of capsule in environmental growth is unknown, al- though speculations have been made that the capsule protects the fungus from desiccation or acts as a food source ...defined role in capsule ... See full document

... Chloroquine was protective in two distinct murine models of cryptococcosis, one that used immunocompetent outbred mice and the other that used SCID mice. These two mouse strains were chosen because they serve as models ... See full document

... mCherry-Cse4. To better discern stages of the cell cycle, the spin- dle was visualized with GFP-tagged ␣-tubulin (GFP-tubulin). In striking contrast to hemiascomycetous budding yeasts (S. cerevi- siae and C. albicans), ... See full document

... C. neoformans strains (Ta- ble 1) was determined by microdissection as previously published for ...C. neoformans were arrayed on a yeast extract-peptone-dextrose (YPD) agar plate maintained at ...C. ... See full document