[PDF] Top 20 The role of mitochondria in stem cell fate and aging

... of mitochondria through mitophagy may help to dispose of damaged ...of stem cell homeostasis is ...skin stem cells compared with the surrounding cells (Salemi et ...of stem cell ... See full document

... of aging that can be traced back to an unwitnessed event that occurred over ...the mitochondria, gave rise to the subsequent accumulation of damaged proteins, lipids, and DNA, thereby fueling aging ... See full document

... key role in the regulation of aging in worms and mammals ...affecting cell signaling. An increased basic understanding of the role for ROS in different cel- lular processes should make it ... See full document

... TAZ, as a transcriptional coactivator for RUNX2-induced Bglap gene expression, is an important endogenous regulator of osteoblast differentiation (29, 39, 40). TAZ has also been shown to suppress adipocyte ... See full document

... of cell”, plays a central role in energy-generating processes so called as ‘‘master of life and ...key role in the aging process and increases the incidence of age-related ...subjects, ... See full document

... adult stem cell numbers and function drives aging- related syndromes (Sahin and Depinho, ...compromise stem cell self- renewal and promote aging (Rossi et ...organismal ... See full document

... a stem cell pool by fine-tuning cellular states balance between self-renewal and ...The fate control rate de- termines the population size of a stem cell ...in stem cell ... See full document

... of HSCs from those pluripotent ESCs requires a transition from endothelial to hematopoietic progenitor cells to resolve HLAmismatching. 21 The hematopoietic transcription factor Runx1 promotes the commitment of ... See full document

... the fate of stem cells in diverse tissues in metazoans (Fre et ...myogenic stem cell fate and differentiation throughout embryogenesis and in the adult, as both embryonic and adult ... See full document

... single/low cell numbers on the temporal and spatial reso- ...study cell biological aspects such as cellular adhesion forces, the cytoskeleton, and for in vitro cul- ture ...the cell number. Major ... See full document

... desired cell response and could also be biodegradable with the aim of being replaced with native tissue after the support and templating role was complete; second-generation biomaterials included ... See full document

... determine cell func- tionality, it is less clear whether they are autonomously driven or a consequence of altered extrinsic ...satellite cell pool is functionally heterogeneous, with subsets enriched for ... See full document

... on cell survival, we used pro- pidium iodide staining in the same clonogenic ...the cell-death rate of either ductal epithelial cells or myoep- ithelial ...the cell lineage ... See full document

... One of the main issues with the current model was that it was unable to predict the spatial patterns of bone formation which were observed during the later stages of the spontaneous repair process by Orth et al. 30 Orth ... See full document

... We recently reported the first characterization of an hsp90-related gene (Djhsp90) in the planarian D. japonica (Conte et al., 2011). The dynamics of changes in the expression profile in response to various stress ... See full document

... beneficial role of E2 signaling in promot- ing intrinsic hematopoietic potential of hPSCs and fur- ther demonstrated that the activation of ER-α enhances generation of hemangioblasts and ...for stem ... See full document

... final fate of MSCs in local microenvironment and the precise mechanisms through which these cells act in a paracrine manner against neighboring somatic and progenitor cells are yet to be elucidated in ...important ... See full document

... of stem cell markers/factors as well as prosurvival pathways, including autophagy(Heddleston et ...cancer stem cells(Zhu et ...a role of autophagy in the adaptation of CSCs to environmental ... See full document

... on stem cell therapy; from basic science to randomized clinical trials ...applicable stem cell therapies in regenerative medicine [27, ...adult stem cell sources has softened ... See full document

... Although all three models consistently describe a stable, albeit dynamic, bimodal distribution of Nanog expression within a population of mESCs (compare with insets in Fig. 3, bottom row), they generate different ... See full document