[PDF] Top 20 The roles of stem cell memory T cells in hematological malignancies
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The roles of stem cell memory T cells in hematological malignancies
... + T cells had superior expansion capacity in vitro and induced superior antitumor activity in multiple myeloma-bearing immunodeficient ...+ T cells or TAA-specific CD8 + T cells ... See full document
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Emerging roles of epithelial-mesenchymal transition in hematological malignancies
... of T cell lymphoma. In anaplastic large-cell lymph- oma (ALCL), Chung et ...ALCL cell line [97]. In diffuse large B cell lymphoma (DLBCL), Lemma et ... See full document
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Notch signaling: its roles and therapeutic potential in hematological malignancies
... in hematological malignancies and the potential therapeutic approaches developed to ...cancer stem cell biology, angiogenesis, cell proliferation and survival, Notch signaling ... See full document
20
Myeloid-derived suppressor cells in hematological malignancies: friends or foes
... suppressor cells (MDSCs) are a newly identified, heterogeneous population of immature mye- loid cells that are characterized by the ability to suppress both innate and adaptive immune ...conflicting ... See full document
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Effects of intensified conditioning on Epstein-Barr virus and cytomegalovirus infections in allogeneic hematopoietic stem cell transplantation for hematological malignancies
... status and aGVHDII-IV were associated with EBV infec- tions; use of ATG, aGVHDII-IV, HLA mismatch, early CsA withdrawal and DLI were associated with CMV infections. Upon multivariate analysis, use of ATG was found to be ... See full document
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T cell senescence and CAR-T cell exhaustion in hematological malignancies
... Treg cells [41–43]. An accumulation of sen- escent CD8 + CD28 − T cells was observed in several solid tu- mors, indicating the use of the suppressive activity of senescent T cells as a ... See full document
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Outcome of allogeneic hematopoietic stem cell transplantation in patients with hematological malignancies.
... for hematological malignancies from April 2004 to December ...mononuclear cells/kg were infused ...white cell recovery was 19±4 days (range:15-23 ...Allogeneic stem cell ... See full document
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Allogeneic CD19-CAR-T cell infusion after allogeneic hematopoietic stem cell transplantation in B cell malignancies
... CAR-T cells without serious complications after allo-HSCT; however, the outcome requires further im- ...of cell therapies is related to the low tumor burden, preemptive therapy should be performed ... See full document
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<p>Survival outcomes and efficacy of autologous CD19 chimeric antigen receptor-T cell therapy in the patient with diagnosed hematological malignancies: a systematic review and meta-analysis</p>
... Receptor T(CAR-T) cell therapy is an immunotherapy approach used in treating cancer which has seen rapid development over the ...CAR-T cell therapy, the patient ’ s T ... See full document
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Antioxidant metabolism regulates CD8+ T memory stem cell formation and antitumor immunity
... Adoptive T cell transfer (ACT) immunotherapy of antitumor T cells redirected with chimeric antigen recep- tors (CARs) or T cell receptors (TCRs) revolutionized cancer ... See full document
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Checkpoint inhibitors in hematological malignancies
... tumor cells assessed by immuno- histochemistry has been associated with better re- sponse to anti-PD-1 therapy in solid tumors as well as in CHL [167, ...immune cell profiles in the TME of biopsy samples ... See full document
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Posttranscriptional stabilization underlies p53 independent induction of p21WAF1/CIP1/SDI1 in differentiating human leukemic cells
... neoplastic cells from patients with various hematological malignancies as well as in normal bone marrow mononuclear cells and in myeloid and lymphoid cell lines independent of their p53 ... See full document
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The MEK inhibitor trametinib separates murine graft-versus-host disease from graft-versus-tumor effects
... without T cells, with or without P815 tumor ...Student’s t test at day 42 (B), and no significant differences were ...P815 cells in the spleens on day 10 were detected as GFP + cells by ... See full document
15
The germ cell the mother of all stem cells
... embryonic stem cells) have been produced over the last few ...important roles for these genes in germline development (Whitney et al , 1996; Zhao et ... See full document
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Signatures of immune reprogramming in anti-CD52 therapy of MS: markers for risk stratification and treatment response
... the T- and B-cell population in the peripheral blood (every 6 months) (see Table ...of cell surface receptors, as well as expression of co- inhibitory molecules, will be analyzed by flow ...tive ... See full document
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Contextual tumor suppressor function of T cell death associated gene 8 (TDAG8) in hematological malignancies
... U937 cell malig- ...immune cells or leukocyte-rich tissue (Table 1 and ...leukemia cells as a model system TDAG8 gene expres- sion was restored to a normal physiological level to test the hypothesis ... See full document
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Strategies to reduce relapse after allogeneic hematopoietic cell transplantation in acute myeloid leukemia.
... Augmented DLI: DLI strategies have included co-administration of immunomodulatory cytokines or chemotherapy to reduce relapse. Levine et al. treated 65 patients with relapsed AML using augmented cytarabine based ... See full document
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Red blood cell transfusion in the resuscitation of septic patients with hematological malignancies
... Septic shock is a frequent and dreaded complication in patients with malignancies. Following the overall improvement in the management of the disease, the last two decades have witnessed dramatic improvements in ... See full document
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The roles of BMP and IL 3 signaling pathways in the control of hematopoietic stem cells in the mouse embryo
... single stem cell integrate extrinsic and intrinsic signals? 2) how do these complex molecular events interact and finally drive a stem cell to decide between self-renewal, proliferation, ... See full document
13
α6-Integrin alternative splicing: distinct cytoplasmic variants in stem cell fate specification and niche interaction
... lens cell differentiation in both chicken and rat embryos [23, ...epithelial cells, α6B is most highly expressed in the equatorial epithelium, and expression of α6B begins to drop as cells initiate ... See full document
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