[PDF] Top 20 Safety and effectiveness of antimalarial therapy in sickle cell disease: a systematic review and network meta analysis

... receive antimalarial prophylaxis [13, 14]; however, the evidence to support the poten- tial beneficial effects of this strategy in SCD patients is limited: i) almost all previous individual studies were ... See full document

... antiretroviral therapy is available, yet safety concerns during pregnancy have been raised, including major congenital abnormalities, preterm delivery, anemia, and low birth weight ...comparative ... See full document

... one systematic review and meta- analyses in adolescents (in press) that identified low num- ber of low quality evidence from head-to head trials and identified large number of trials that compared ... See full document

... primary analysis was limited to RCTs, with non- randomized studies included in an additional analysis to evaluate the robustness of the ...Subgroup analysis was conducted to determine whether the ... See full document

... Direct comparisons and assessment of heterogeneity We will first describe the results narratively and, where pos- sible, the direct evidence will be pooled. Given that we ex- pect clinical and methodological ... See full document

... When considering HSCT, the question remains whether its risk to benefit ratio justifies it. Observations of case re- ports published to date suggest that sustained clinical re- mission with HSCT is initially likely to ... See full document

... ACCEPTED MANUSCRIPT resourced countries, antibody tests are performed more frequently, increasing the likelihood of antibody detection. In well-resourced countries, patients with SCD often receive transfusions for which ... See full document

... refractory disease. Moxibustion therapy for insomnia shows some advantages compared with conventional ...This systematic review and meta-analysis of randomized controlled trials ... See full document

... our analysis could arise from different tumor types, the very heterogeneous study population with pre-treated disease and the ethnicity ...subgroup analysis of melanoma and non-small-cell lung ... See full document

... reparative therapy for patients suffering from post-stroke ...current review summarises the current evidence for use of stem cell therapies in stroke from early-phase clinical ...The safety ... See full document

... stratified analysis was done pertaining to the different SCD geno- types which have been shown to affect the occurrence of ...and sickle cell car- riers live are ... See full document

... The meta-analyses were carried out with the software STATA (version 13; StataCorp, College Station, TX) using the metaprop ...the meta-analyses were presented as forest ... See full document

... SCD affects millions of people worldwide. 3 It is associated with severe complications that have a negative impact on their quality of life and survival. 3 4 The incidence and the prevalence of SCD in Africa have kept ... See full document

... of disease severity to correlate with intelligence, which may explain differences in IQ between patients with normal MRI and healthy ...this review find a negative association between chronologic age and ... See full document

... This review and meta-analysis provides contemporary prevalence estimates of ACS/pneumonia and PTE in this ...This review and meta-analysis should encourage renewed efforts to ... See full document

... Hydroxyurea has various effects-the most important is increase in HbF level. It also increases the total haemoglobin and hematocrit. It increases the mean corpuscular volume of red blood cells and improves their ... See full document

... genetic disease, despite not currently indicating a proportion of correct diagnosis results, which would encourage the technique for clinical ...this disease is developed, so the parents of the foetus can ... See full document

... the cell group vs control group ...our meta-analysis and subsequent subgroup analysis are promising, they should be interpreted with ...robust meta-analysis for human ...future ... See full document

... In jaw bones, it is very rare, but when present, it resides more commonly in the posterior area of the mandible. This is explained by the lower blood flow in the jaw. In- cidence of this amounts to 5% of all the ... See full document

... DNA analysis, prenatal diagnosis, chorionic villus sampling, amniocentesis and fetal blood sampling ...alternative therapy for SCD ...to review pharmacological therapies for SCD treatment and other ... See full document