[PDF] Top 20 Sak and its potential role in the DNA damage response.
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Sak and its potential role in the DNA damage response.
... Overexpression and loss-of function experiments have also shed light on the roles of mammalian Plk members. When Plkl was depleted in HeLa cells using siRNA, cells arrested at G2/M phase and contained the typical ... See full document
113
Nicotinamide Suppresses the DNA Damage Sensitivity of Saccharomyces cerevisiae Independently of Sirtuin Deacetylases
... DNA damage. It is unclear if Msn2 and Msn4 are regulated by the DNA damage checkpoint or whether they respond to a more general stress response that might be activated in the presence ... See full document
17
Scorpins in the DNA Damage Response
... of its first names was B-cell antigen receptor Ig beta- associated protein 1, (IBAP-1) even if there is no evidence supporting any molecular role of this protein in B-cell signaling or the immune system in ... See full document
24
Antioxidant and iron chelating potential of Pongammia pinnata and its role in preventing free radical induced oxidative damage in plasmid DNA
... for its antidiabetic [13], antihyperglycaemic and antilipidperoxidative [14], anti-inflammatory [15], antiplasmodial [16], antibacterial [17], antiviral [18], ulcerprotective [19], gastroprotective [20], ... See full document
15
The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeutics
... in response to DSB, as this ubiquitination event is important for the formation of open and bio- chemically accessible chromatin fiber that is conducive to DNA repair ... See full document
15
HIV-1 Tat and AIDS-associated cancer: targeting the cellular anti-cancer barrier?
... of DNA damage is a double- strand DNA break (DSB) ...a DNA repair-deficient cell ...lethal DNA lesion, cells have developed several mechanisms to repair DSBs, which are important for ... See full document
8
Phosphatases in the cellular response to DNA damage
... or DNA damage specific regulation of CHK1 via Wip1 ...following DNA damage are regulated by PP1, PP2A, and ...important role in recovery from the DDR ... See full document
12
Singular v Dual inhibition of SNF2L and its isoform, SNF2LT, have similar effects on DNA Damage but opposite effects on the DNA Damage Response, Cancer Cell Growth Arrest and Apoptosis
... regulation, DNA repair, DNA recombination, and chromatin ...ATP-dependent DNA or RNA ...along DNA, unwinding the duplex in the ...confers DNA and nucleosome binding properties to the ... See full document
15
Hydrophobic bile acids, genomic instability, Darwinian selection, and colon carcinogenesis
... key role in colon ...(DNA damage, endoplasmic reticulum stress, mitochondrial damage) are ...oxidative DNA damage, p53 and other mutations, micronuclei formation and ...decrease ... See full document
30
The Smc complexes in DNA damage response
... Unlike cohesin and condensins which have other major non-DNA repair functions in chromosome biology, the Smc5/6 complex is primarily required for DNA repair. The Smc5/6 complex is composed of Smc5, Smc6, ... See full document
11
p16 and ARF: activation of teenage proteins in old age
... the role of this key component of the senescence path- way during ...in response to DNA damage and improved tumor suppression but did not enhance aging phenotypes ... See full document
5
The DNA damage response promotes polyomavirus JC infection by nucleus to cytoplasm NF kappaB activation
... a role in the reactivation of dor- mant virus ...the DNA damage response (DDR) is also known to result in the activation of the NF-κB signaling pathway, a phenomenon known as nucleus to ... See full document
10
Inhibition of NIPBL enhances the chemosensitivity of non-small-cell lung cancer cells via the DNA damage response and autophagy pathway
... To more comprehensively elucidate the role of NIPBL in lung cancer cells, we performed mass spectrometry to iden- tify proteins whose levels were altered in NIPBL siRNA- treated cells. All proteins identified were ... See full document
8
Characterisation of CIP29:a potential target of the eukaryotic DNA damage response
... chromosomes. DNA damage-induced genomic alterations may arise from multiple sources, both endogenous, and exogenous to the cell (Shen, ...during DNA replication, and exposure to the reactive oxygen ... See full document
88
Role and Regulation of CIEBPa in Response to DNA Damage
... inhibit DNA synthesis in response to ionizing radiation is known as radio-resistant DNA synthesis ...the role of ATM and NBS1 in S- phase ...in response to DNA ...in ... See full document
155
<p>Digital Immune-Related Gene Expression Signatures In High-Grade Serous Ovarian Carcinoma: Developing Prediction Models For Platinum Response</p>
... is DNA damage, different DNA-damage repair systems stand in the focus of research for the prediction of platinum response, 5,30 including nucleotide excision repair, mis- match repair, ... See full document
13
CDC7/DBF4 Functions in the Translesion Synthesis Branch of the RAD6 Epistasis Group in Saccharomyces cerevisiae
... for DNA replication in eukary- otes from yeast to ...for DNA damage-induced mutagenesis, one of several postreplicational DNA damage tolerance mechanisms mediated by the RAD6 epistasis ... See full document
14
THE ROLE OF REPLICATION PROTEIN A LARGE SUBUNIT FAMILY IN PATHOGEN-INDUCED DNA DAMAGE IN ARABIDOPSIS THALIANA, Nancy Lynn Fernandes
... in response to pathogen ...(CPT) DNA damaging agent to determine hypersensitivity using rpa1c and rpa1e single mutants (Aklilu et ...In response to CPT DSB damage rpa1c mutant displayed a high ... See full document
119
Sperm DNA damage and its role in IVF and ICSI
... A potential explanation for the disparate findings seen in contemporary meta-analyses on the impact of sperm DNA damage when assessing clinical pregnancy and miscarriage rates in IVF and ICSI could ... See full document
10
Radio-resistant mesenchymal stem cells: mechanisms of resistance and potential implications for the clinic
... in DNA replication, stress response, DNA repair and translation initiation [70, ...increased DNA damage repair and improved long-term survival after exposure to ionizing radiation ... See full document
15
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