[PDF] Top 20 Sampling from T cell receptor repertoires
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Sampling from T cell receptor repertoires
... samples from a large repertoire, such as are obtained in single-cell sequenc- ing experiments of T cell receptors, present mathematical ... See full document
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Eye on the B-ALL: B-cell receptor repertoires reveal persistence of numerous B-lymphoblastic leukemia subclones from diagnosis to relapse.
... the T/C qPCR transcript ratio levels and the red axes (left) to the percentage of sequences in the corresponding clusters (log2 ...percentages from nine B-ALL patients of BM blasts (top panels) and ... See full document
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Sequence analysis of T-cell repertoires in health and disease
... 1 T-cell receptor-antigen-peptide-MHC interaction and TCR gene ...A T-cell (pink) encountering an antigen-presenting cell (APC; ...The T-cell receptor (TCR; ... See full document
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Profiling tissue-resident T cell repertoires by RNA sequencing
... of T cell infiltration is typically about 2 % (see “Methods”), we would expect ...sequences from RNA-seq data, we generated TCR-seq for TCR beta chain (1,411,056 reads; 2823 unique CDR3β sequences) ... See full document
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Multivariate analysis using high definition flow cytometry reveals distinct T cell repertoires between the fetal–maternal interface and the peripheral blood
... In contrast with the CD4 + subset, CD8 + and Treg subsets exhibited considerable TR variation between anatomical sites. Between DMC and PBMC, CD8 + repertoire variation was strik- ing with absolute differences in single ... See full document
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Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics
... complexes reveal equally split footprints across the TCR α-chains and β-chains with the majority of bound Ag contacts focused on the CDR3 loops. These structural constraints may limit the final frequen- cies of cognate ... See full document
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Survivin specific T cell receptor targets tumor but not T cells
... survivin-specific T cell receptors (TCRs) isolated from allogeneic HLA–mismatched TCR repertoires has, however, been impeded by the inability of these TCRs to distinguish healthy cells ... See full document
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Immunodominance of a low affinity major histocompatibility complex binding myelin basic protein epitope (residues 111 129) in HLA DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire
... expressing T cells were ...expanded T cell ...generated from different sampling time points, indicating their persistence at detectable levels of frequency even several years apart ... See full document
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Immune receptor repertoires in pediatric and adult acute myeloid leukemia
... arising from somatic mutations can induce T cell-mediated elimination of cancer cells ...antigen-specific T cell activation is clonal expansion, which can be approximated by the inverse ... See full document
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Huth, Alina (2019): High-resolution analysis of human cytomegalovirus-specific T-cell receptor repertoires. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... derive from hematopoietic stem cells in the bone marrow and are named af- ter their site of maturation, the thymus (Murphy and Weaver ...progenitor T cells enter the thymus, they receive a signal via their ... See full document
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T cell receptor-Vβ repertoires in lung and blood CD4+ and CD8+T cells of pulmonary sarcoidosis patients
... Knowledge about TCR gene segment expression in sar- coidosis can provide insights to the pathogenic process and assist the finding of a potential disease triggering anti- gen. Previous studies aimed at mapping the TRC Vα ... See full document
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Severity of Acute Infectious Mononucleosis Correlates with Cross Reactive Influenza CD8 T Cell Receptor Repertoires
... CD8 T-cell expansion; symptoms can vary greatly in severity from a mild short influenza-like illness to a more severe syndrome with sore throat, lymphadenop- athy, splenomegaly, hepatomegaly, and ... See full document
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Narrowing of Human Influenza A Virus-Specific T Cell Receptor α and β Repertoires with Increasing Age
... TCR repertoires in the individual middle-aged and older donors, giving an overview of their general organiza- ...TCR repertoires differ in middle-aged and older ... See full document
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From IMGT-ONTOLOGY to IMGT/HighVQUEST for NGS Immunoglobulin (IG) and T cell Receptor (TR) Repertoires in Autoimmune and Infectious Diseases
... immune repertoires with high-quality data at the forefront of basic and clinical ...the repertoires against pathogens and for the analysis of IG somatic hypermutations in leukemia, lymphoma and myeloma, and ... See full document
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Selective expansion of specific T cell receptors in the inflamed colon of Crohn's disease
... LPL from disease- active and disease-inactive tissue suggested that their TCR repertoires might be different with respect to CDR3 size and ...of T cells appeared to have occurred in some ...Isolated ... See full document
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Rearrangement of the genes for the beta and gamma chains of the T cell receptor is rarely observed in adult B cell lymphoma and chronic lymphocytic leukemia
... the T cell receptor in DNA from 100 consecutive cases of B cell lymphoma and B cell chronic lymphocytic leukemia (B-CLL), and compared the findings with those in 18 T ... See full document
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MaGiK Method of T-Cell Receptor Repertoire Analysis
... peak centered at 212 base pairs, or peak 5. Visually, an expan- sion is evident at peak 5. Notice that even though only one peak was expanded in this example, the individual CDR3 length proportions of the total TCRV ... See full document
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Recombinative events of the T cell antigen receptor delta gene in peripheral T cell lymphomas
... productive rearrangements could be ascribed to V delta 1J delta 1 joining in 3 cases and VJ delta 1 joining in 2 cases according to the combined pattern of DNA hybridization with the appropriate probes and of cell ... See full document
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The structure and function of human phosphoinositide 4-kinases
... The finding that Ptdlns 4Kp is sensitive to PI 3-kinase inhibitors is important because it calls the specificity of such reagents into question. Wortmannin has been a valuable tool in dissecting PI 3-kinase function ... See full document
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T-cell receptor specificity maintained by altered thermodynamics
... stem from the possibility that high affinity TCRs, par- ticularly those where interaction between the TCR and the MHC component have been increased, might recognize an even greater number of cognate ... See full document
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