[PDF] Top 20 Scribble Is Essential for Olfactory Behavior in Drosophila melanogaster

... wild-type olfactory phenotype by the precise excision of These interactions result in the organization and traf- the P element (Figure 3); (4) correlation of scrib mRNA ficking of multivalent protein complexes ... See full document

... in Drosophila (Piper et ...of Drosophila by affecting both growth rate and body size via the insulin signaling pathway (Shin et ...of essential amino acids (eAAs) can induce increased yeast intake ... See full document

... exons, introns or in close proximity to promoter/enhancer regions of the candidate genes (Figure 3.1). Rigorous evidence that the tagged gene is indeed responsible for the mutant phenotype is generally provided by ... See full document

... an essential role in catalysis of acetyl- choline hydrolysis and aging through cation- π interactions be- tween the choline or carbocation leaving group and the indole moiety of Trp84 (23, ... See full document

... in olfactory neurons encode serine/threonine kinases, proteins well known to perform roles in regulation of cell signalling ...many essential roles not related to olfaction and we were unable to test these ... See full document

... aggressive behavior is thus a typical quantitative trait ...aggressive behavior, we know very little of the genes and genetic networks affecting natural variation in ...aggressive behavior may be ... See full document

... We can thus show that functional imaging of cAMP in insect OSNs using the Epac1-camps indicator is a valid method to investigate the dynamics of this second messenger and further experiments could focus on the functional ... See full document

... which Drosophila and its symbionts come to be associated with one ...an olfactory circuit used by Drosophila to avoid harmful microorganisms ...way, Drosophila would be attracted to and ... See full document

... This is demon- strated clearly in the accompanying paper where it is used to analyze effects of P-element insertions on bristle number and viability (LYMAN et al. Here, w[r] ... See full document

... We used targeted RNAi-mediated suppression of Obp expression to quantify the behavioral response profiles of OBPs to a battery of odorants. The extent of RNAi-mediated knock- down of Obp gene expression varied among the ... See full document

... PTX/+ flies exposed to various concentrations of ethyl ace- tate (Fig 5A). PTX was found to repress EAG responses over a 1000-fold range of stimulus intensities (p < 0.0001); although the degree of repression was ... See full document

... Mosquito control is the primary mechanism for preventing dengue, yellow fever, chikungunya and Zika, all of which result from viruses transmitted by the daytime-biting mosquito Aedes aegypti, which is closely associated ... See full document

... The genetic tractability, economic efficiency and general ease of use of D. melanogaster helps to bridge a fundamental gap in therapeutic drug discovery in nephrolithiasis. The role of DM, however, must be clearly ... See full document

... By combining quantitative network analysis with genetic tools, the study of Schneider et al. (2012b) provides a first look at sensory genes that contribute to the organization of social networks in an animal group. ... See full document

... In addition, we noticed a large variability of responses across and within generations (Fig. 2). Such oscillations are frequently observed in experimental selection protocols and are particularly observed in populations ... See full document

... average Drosophila melanogaster quantum bump of approximately 10 pA represents simultaneous activation of only approximately 15 channels (Henderson et ... See full document

... This study demonstrated that sublethal IMI exposure interferes with the Duox pathway in D. melanogaster. IMI-induced immunosuppression was observed by an increase in total bacteria and yeast, which has been ... See full document

... new sterile medium generally resulted in a drop in the bacterial load. We also observed a correlation between bacterial counts and the amount of food in the gut, suggesting that the inoculum level of the food, time since ... See full document

... allele, while maintaining a controlled genetic back- ground. This represents at present a difficult challenge, especially when alleles with subtle effects on quantitative phenotypes are being analyzed, and will be ... See full document

... deformation as an assay to monitor the ability of S. poulsonii to maintain a helicoidal shape and hence its capacity to efficiently generate ATP from several metabolites, including glucose, fruc- tose, trehalose, or ... See full document