[PDF] Top 20 Selective targeting of human cells by a chimeric adenovirus vector containing a modified fiber protein.
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Selective targeting of human cells by a chimeric adenovirus vector containing a modified fiber protein.
... Ad5 fiber attachment receptor on primary human cells is poorly characterized, largely due to the fact that its identity is ...many human cell lines and a number of primary cells are ... See full document
9
Construction of Metabolically Biotinylated Adenovirus with Deleted Fiber Knob as Targeting Vector
... the fiber pro- tein can be efficiently biotinylated by human holocarbox- ylase synthetase presented in HEK-293 cells ...9R modified fiber. We found that the 9R modified ... See full document
6
Functional and Selective Targeting of Adenovirus to High-Affinity Fcγ Receptor I-Positive Cells by Using a Bispecific Hybrid Adapter
... culture. Cells were grown in RPMI 1640 plus 10% fetal calf serum (FCS) unless indicated ...leukemia) cells were provided by ...leukemia) cells were obtained from ...B-lymphoma) cells were ... See full document
10
Adenovirus Vector Pseudotyping in Fiber-Expressing Cell Lines: Improved Transduction of Epstein-Barr Virus-Transformed B Cells
... A-10 cells were purchased from the American Type Culture ...Ad5 fiber protein ...B-10 cells are a subclone of the JR LCL and were produced by limiting dilution followed by PCR analysis to ... See full document
9
Antibody-Mediated Targeting of an Adenovirus Vector Modified To Contain a Synthetic Immunoglobulin G-Binding Domain in the Capsid
... reagents containing N-hydroxysuccinimide, N-ethyl-N⬘-(3,3-diethylaminopropyl)-carbodi- imide, and ethanolamine-HCl were obtained from BIAcore AB (Freiburg, Ger- ...purified fiber knob proteins with and ... See full document
12
A High-Capacity, Capsid-Modified Hybrid Adenovirus/Adeno-Associated Virus Vector for Stable Transduction of Human Hematopoietic Cells
... vectors containing a ...for human ␥-globin included the  promoter from ⫺127 to the  initiation codon, which was connected in frame with the ␥ coding region partially deleted for intron 2 ...The ... See full document
9
Fiber Shaft-Chimeric Adenovirus Vectors Lacking the KKTK Motif Efficiently Infect Liver Cells In Vivo
... of fiber shaft- chimeric Ads in ...liver cells in vivo was described (2, 31, ...receptor-related protein, thus allowing for efficient virus entry into hepatocytes and Kupffer cells in a ... See full document
11
Modulation of Adenovirus Vector Tropism via Incorporation of Polypeptide Ligands into the Fiber Protein
... other protein sequence. While specific targeting to VPAC receptors has not been achieved in this work, the ...to cells which, similar to CHO cells, are refractory to transduction by regular ... See full document
11
Characterization of an Adenovirus Vector Containing a Heterologous Peptide Epitope in the HI Loop of the Fiber Knob
... recombinant adenovirus vectors for gene therapy applications could potentially be improved by designing targeted vectors capable of gene delivery to selected cell types in ...such targeting, we are ... See full document
9
Original Article A fiber-modified adenovirus co-expressing HSV-TK and Coli.NTR enhances antitumor activities in breast cancer cells
... hTERT-driven adenovirus vector resulted in additive anti-tumor effects in breast cancer cells in vitro and in ...cancer cells express low level of coxsackie-adenovirus receptor (CAR), ... See full document
11
Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins.
... two modified vectors were not dramatically af- fected by the addition of ligands onto the end of the fiber ...the modified vectors were compared on different cell types ...with cells, and the ... See full document
9
Tissue-Specific, Tumor-Selective, Replication-Competent Adenovirus Vector for Cancer Gene Therapy
... additional human cancer cell lines, ...Hep3B cells, the SPB promoter is not expected to be active in these ...(8). Cells in mono- layers were infected with 10 PFU of KD1-SPB or KD3/cell, and then at ... See full document
11
Chimeric Human Immunodeficiency Virus Type 1 Containing Murine Leukemia Virus Matrix Assembles in Murine Cells
... chimeras. Chimeric pro- viruses were generated by substituting the MA coding region of the infectious HIV-1 dualtropic clone DH-12 (15) with the corresponding region of Moloney (Mo) ...293 cells were ... See full document
8
Selection of nonfastidious adenovirus species in 293 cells inoculated with stool specimens containing adenovirus 40
... Of 35 stool specimens isolated and examined in 293 cells, 15 isolates contained adenovirus species 40 Ad40, and 4 of these 15 isolates also contained a nonfastidious adenovirus species A[r] ... See full document
5
Selective infection of human T-lymphotropic virus type 1 (HTLV-1)-infected cells by chimeric human immunodeficiency viruses containing HTLV-1 tax response elements in the long terminal repeat.
... in cells lack- ing nuclear NF- k ...expressing cells, although enhanced replication was observed when Sp1 sites were ...virus, containing Sp1 sites, was restricted to Tax-ex- pressing ...that ... See full document
10
Enhancement of Adenovirus Vector Entry into CD70-Positive B-Cell Lines by Using a Bispecific CD70-Adenovirus Fiber Antibody
... BsAb. The anti-CD70 monoclonal antibody (MAb) Ki-24 used to construct the anti-CD70–antifiber BsAb was produced from a hybridoma cell line that was a gift from H. Stein. The anti-CD70-antifiber BsAb were made, as ... See full document
7
A Single Amino Acid in the Adenovirus Type 37 Fiber Confers Binding to Human Conjunctival Cells
... which human Ad recognizes cellular recep- ...to cells via interaction with a 46-kDa protein ...display selective tropism for certain ocular cell ...showed selective binding and ... See full document
5
Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: a potential theranostic agent
... PC-3 cells of DSPC/MonY-BN liposomes was obtained ...of cells with DSPC/ MonY-BN/Dox showed significantly lower cell survival compared with DSPC/Dox-treated cells, in the presence of 100 ng/mL and ... See full document
11
Human herpesvirus 7 infection of lymphoid and myeloid cell lines transduced with an adenovirus vector containing the CD4 gene.
... HeLa cells expressing surface CD4 ...CD4-negative cells into which the CD4 gene has been trans- ...an adenovirus vector to transfer the cDNA for CD4 into CD4-negative or weakly positive ... See full document
5
Construction of the Chimeric HSP70 - E7 Vector and Evaluation of its Protein Production
... of modified HSP70 using specific primer set containing designed restriction enzyme and linker fragment was excised from the agarose gel, purified by Bioneer extraction kit (Korea) and applied for cloning in ... See full document
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