[PDF] Top 20 Sequelae of multidrug-resistant tuberculosis: protocol for a systematic review and meta-analysis

... and analysis We will perform a systematic review and meta-analysis of published studies reporting sequelae of ...MDR-TB sequelae will include any clinical, psychological, ... See full document

... Aside from the large number of studies identified, strengths of this study included the use of a standard protocol and predefined analyses using bivariate random-effects models. However, we also recognise some ... See full document

... Multidrug-resistant tuberculosis (MDR-TB), defined by resistance to isoniazid and rifampicin, the two front-line antimicrobial drugs used to treat TB, presents substan- tial barriers to the ... See full document

... With the advent of effective chemotherapy however it soon became clear that medical therapy offered a super- ior option and enthusiasm for surgical approaches waned. In the current context of increasing drug resist- ant ... See full document

... for Tuberculosis and Lung Diseases, Riga, Latvia, 30 CAPRISA, MRC TB-HIV Pathogenesis Unit, Durban, South Africa, 31 Director Health Services, Kashmir, India, 32 Alpert Medical School of Brown University, ... See full document

... drug resistant TB is not well understood in Ethiopia [13 – ...this meta-analysis was firstly, to determine the pooled prevalence of MDR-TB among newly diagnosed and previously treated cases in ... See full document

... This meta-analysis revealed that a low MDR-TB treat- ment success rate among patients, which is far from the WHO target to be achieved by ...based meta-analysis is recommended to identify ... See full document

... ‘multidrug resistant tuberculosis’, ‘extensively drug resistant tuberculosis’, ‘lin- ezolid’, ‘zyvox’, ‘efficacy’ and ...and review articles were excluded as well as case reports ... See full document

... Multi-drug-resistant tuberculosis (MDR-TB) has emerged as a challenge to global tuberculosis (TB) control and remains a major public health concern in many ... See full document

... The review showed that MDR-TB is continued to become a serious public health problem in ...this review was comparable with previous stud- ies, yet it is a ... See full document

... Confounding in observational studies reporting un- adjusted data is a well-known source of bias. To miti- gate this bias, we included risk factors that were analyzed in multivariate analyses. The choice of the control ... See full document

... trend analysis in the data rich area and spatial interpolation analysis in central and eastern regions based on city scale; Third, due to the geograph- ical, historical and cultural factors [29, 30], few ... See full document

... Confounding in observational studies reporting unadjusted data should be acknowledged. For example, patients with re- sistant P. aeruginosa represent a sicker population, who may have been treated with more antibiotics ... See full document

... data analysis; clear method of participant selection; and rep- resentativeness of study participants to the population of MDR-TB and HIV co-infected ...final analysis compared to original population ... See full document

... carbapenemase-producing, multidrug-resistant (MDR), or extensively drug-resistant (XDR) Gram-negative bacteria constitute a major therapeutic ...this systematic review and ... See full document

... trial protocol, available with the full text of this article at ...institutional review boards for all ...and analysis of the data and made the decision to submit the manuscript for ... See full document

... Selection of studies Relevant articles were reviewed and examined for eligi- bility beginning with the abstract and followed by full text review. The following inclusion criteria were ap- plied: original study; ... See full document

... active tuberculosis (TB) and complicates its ...multi-drug-resistant tuberculosis (MDR-TB). The aim of this meta-analysis was to summarize available evidence on the association of DM ... See full document

... Treatment for drug resistant TB patients has focused on hospital and ambulatory based management [2–4]. The rationale for this has been to monitor complex drug regi- mens, optimize adherence, and limit community ... See full document

... Figure 4. Distribution of MRSE infection in Iran based on the rate of incidence pathogenic bacteria among the hospital wards, the dis- organized implementation of prophylactic hygiene mea- sures, inadequate staff ... See full document