[PDF] Top 20 Global sequence variation in the histidine rich proteins 2 and 3 of Plasmodium falciparum: implications for the performance of malaria rapid diagnostic tests
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Global sequence variation in the histidine rich proteins 2 and 3 of Plasmodium falciparum: implications for the performance of malaria rapid diagnostic tests
... earlier malaria RDTs, Paracheck Pf (Orchid Biomedi- cal Systems, India) and ICT Malaria (ICT Diagnostics, South Africa), yielded a binary logistic regression model that was able to predict detection ... See full document
12
Effect of Sequence Variation in Plasmodium falciparum Histidine Rich Protein 2 on Binding of Specific Monoclonal Antibodies: Implications for Rapid Diagnostic Tests for Malaria
... diagnose malaria infections is funda- mental to both the management of individual patients as well as public health efforts to control the ...available. Tests to identify parasite nucleic acids, principally ... See full document
6
Identification of Optimal Epitopes for Plasmodium falciparum Rapid Diagnostic Tests That Target Histidine Rich Proteins 2 and 3
... a sequence does not necessarily represent the number of antibodies that could bind to the cognate epitope in the HRP2 protein but rather is an indication of the binding ... See full document
9
Plasmodium falciparum histidine rich protein 2 diversity and the implications for PfHRP 2: based malaria rapid diagnostic tests in Ghana
... Conclusion Plasmodium falciparum parasites that lack pfhrp2 alone or in addition to pfhrp3 have been identified in two regions of Ghana based on the assumption that dele- tions in exon 2 of these ... See full document
8
Genetic variation in histidine rich proteins among Indian Plasmodium falciparum population: possible cause of variable sensitivity of malaria rapid diagnostic tests
... genetic variation in these diagnostic genes on performance of RDTs is also applicable for most of the commercial PfHRP2-based ...geographical malaria endemic region of country is needed to ... See full document
7
Circulating antibodies against Plasmodium falciparum histidine rich proteins 2 interfere with antigen detection by rapid diagnostic tests
... severity of infection. The antibody-antigen interaction and its potential impact on RDT performance are illus- trated in Additional file 5. The impact of antibody blocking on the detection sen- sitivity of RDTs ... See full document
12
Modelling the dynamics of Plasmodium falciparum histidine rich protein 2 in human malaria to better understand malaria rapid diagnostic test performance
... The model and results presented in the current study assume all PfHRP2 antigen produced by parasites in nat- ural human infection is available for measurement. However, it is possible that PfHRP2 binds or complexes with ... See full document
9
Malaria surveys using rapid diagnostic tests and validation of results using post hoc quantification of Plasmodium falciparum histidine rich protein 2
... detect malaria antigenaemia is not uniform, and numerous factors could lead to dif- ferent test performance in different ...P. falciparum transmission intensity should interpreted in the appropriate ... See full document
7
Genetic diversity of Plasmodium falciparum histidine rich protein 2 (PfHRP2) and its effect on the performance of PfHRP2 based rapid diagnostic tests
... summary, sequence analysis has identified new repeats in addition to the reported identified in previous studies which increase the genetic diversity of the pfhrp2 gene, additional reason for genetic ... See full document
5
Genetic variability of Plasmodium falciparum histidine rich proteins 2 and 3 in Central America
... Background: Malaria is an important disease in many tropical countries. Rapid diagnostic tests (RDTs) are valuable tools for diagnosing malaria in remote ...of Plasmodium ... See full document
10
Pan Plasmodium band sensitivity for Plasmodium falciparum detection in combination malaria rapid diagnostic tests and implications for clinical management
... HRP2 sequence with a frequency of 8–25, depending on the motif and specific ...diminished performance of the pan test bands because for all except two tests included in this analysis the pan test ... See full document
8
Accuracy of a Plasmodium falciparum specific histidine rich protein 2 rapid diagnostic test in the context of the presence of non malaria fevers, prior anti malarial use and seasonal malaria transmission
... of malaria in the health ...the tests and there is a certain level of uncertainty if these might have affected test ...of malaria RDTs often exceed recommended temperatures and this may affect test ... See full document
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Plasmodium falciparum parasites lacking histidine rich protein 2 and 3: a review and recommendations for accurate reporting
... Gatton 2 , John Barnwell 3 , Peter Chiodini 4 , James McCarthy 5 , David Bell 6 and Jane Cunningham 7* Abstract Malaria rapid diagnostic tests (RDTs) play a critical role in ... See full document
8
Development and performance evaluation of a novel immunofluorescence chromatographic assay for histidine rich protein 2 of Plasmodium falciparum
... P. falciparum control panel was screened against commercially available RDTs, including Wondfo One-Step Malaria, the results showed that all samples with 5000 parasite/μl concentrations are within the de- ... See full document
8
Pfhrp2 and pfhrp3 polymorphisms in Plasmodium falciparum isolates from Dakar, Senegal: impact on rapid malaria diagnostic tests
... the rapid and appropriate treatment of ...the histidine-rich protein 2 (PfHRP2)-based rapid diagnostic test (RDT) Palutop+4 W was assessed ...detect malaria by this test ... See full document
8
Identification of Plasmodium falciparum histidine rich protein 2 in the plasma of humans with malaria
... falciparum proteins clearly shown to be released from intact, infected erythrocytes during parasite develop- ment (6). The others appear to be either shed or released when schizont segme[r] ... See full document
6
Cerebrospinal fluid Plasmodium falciparum histidine rich protein 2 in pediatric cerebral malaria
... severe malaria [21, ...burden malaria settings. Within this cohort of children with CM, plasma PfHRP-2 did not show an association with mortality, probably because a very select group of patients ... See full document
10
Dried Plasmodium falciparum infected samples as positive controls for malaria rapid diagnostic tests
... test performance may be compromised, espe- cially if tests are stored for prolonged periods at such ...for malaria diagnosis, ambient tem- peratures are frequently above 30°C and, therefore, in ... See full document
8
Devices for Rapid Diagnosis of Malaria: Evaluation of Prototype Assays That Detect Plasmodium falciparum Histidine Rich Protein 2 and a Plasmodium vivax Specific Antigen
... the rapid diagnosis of ...single malaria species, Plasmodium ...proprietary Plasmodium vivax-specific antigen, in addition to the antibody directed against ...P. falciparum ... See full document
9
Rapid diagnostic tests for diagnosing uncomplicated non-falciparum or Plasmodium vivax malaria in endemic countries
... for variation in sensitivity by brand (WHO ...clinical malaria and inferences about the results relate to this context, and not to mass surveys of well pop- ...vitro performance, stability and costs ... See full document
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