[PDF] Top 20 Signal dynamics in Sonic hedgehog tissue patterning
Has 10000 "Signal dynamics in Sonic hedgehog tissue patterning" found on our website. Below are the top 20 most common "Signal dynamics in Sonic hedgehog tissue patterning".
Signal dynamics in Sonic hedgehog tissue patterning
... V3/MN patterning in the vertebrate neural tube; however, given the Shh threshold and kinetic data from chick V3/MN patterning used for our parameter estimates (see Materials and methods), the model predicts ... See full document
13
The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity
... regulated patterning, proliferation and survival of progenitors are separable activities, suggesting that each of these cellular properties is an independently regulated response to Shh/Gli ...and ... See full document
12
Tissue specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate
... pp patterning and organ development. We used tissue- specific Cre driver strains to selectively delete or ectopically activate SHH signaling in NC mesenchyme or pharyngeal endoderm by expression or activity ... See full document
11
Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics
... Most JBTS genes have been identified through linkage analy- sis in consanguineous families. Using such an approach, we have mapped a novel JBTS locus, JBTS12, to chromosome 15q25.3– q26.3 in an Egyptian family. One gene ... See full document
7
Multiphasic and tissue specific roles of sonic hedgehog in cloacal septation and external genitalia development
... tamoxifen to pregnant females at the embryonic days shown along the top line. Hedgehog signaling was inactive 24 hours after tamoxifen treatment (confirmed by absence of Ptch1; data not shown). (A-C) Shh is ... See full document
9
The Role of Sonic Hedgehog in the Hypothalamus
... telencephalon (Supplemental Fig. 1a). To address the function of this hypothalamic source of Shh, we used an SBE2-cre mouse line to conditionally inactivate a floxed allele of Shh, thus producing a hypothalamic specific ... See full document
120
Hedgehog proteins and parathyroid hormone‐related protein are involved in intervertebral disc maturation, degeneration, and calcification
... and hedgehog signaling play an important role in chondrocyte development, (hypertrophic) differentiation, and/or calcification, but their role in intervertebral disc (IVD) degeneration is ...and hedgehog ... See full document
16
<p>Antidepressant, anti-inflammatory, and antioxidant effects of electroacupuncture through sonic hedgehog–signaling pathway in a rat model of poststroke depression</p>
... EA has been found to resist oxidation by reducing oxidants like reactive oxygen species (ROS), nitric oxide, inducible nitric oxide synthase, and COX2 in brain tissue after ischemic stroke 22 and chronic ... See full document
9
Sonic hedgehog in vertebrate neural tube development
... tube patterning in embryos lacking different ciliary components revealed that cilia are required for maintaining the signaling pathway in its ‘off-state’ as well as for transducing the ac- tive signal ... See full document
11
Sonic hedgehog, secreted by amacrine cells, acts as a short range signal to direct differentiation and lamination in the zebrafish retina
... The Hedgehog (Hh) family of secreted signaling proteins participates in patterning the zebrafish ...stalk tissue at the expense of neural retina (Ekker et ...a signal originating from the ... See full document
10
Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog
... instead forms hyperproliferative follicle-like structures that do not produce mature hair shafts (19, 39). In con- trast, gain-of-function models in embryonic develop- ment show that forced expression of Shh or of genes ... See full document
11
A molecular analysis of amphibian limb regeneration
... newt Sonic hedgehog homologue and analyse its expression during newt limb development and ...newt Sonic is expressed at the posterior margin of the embryonic newt limb bud, which would suggest that ... See full document
250
Regulation of ventral midbrain patterning by Hedgehog signaling
... molecule sonic hedgehog (SHH) is sufficient to specify a striped pattern of cell fates (midbrain ...how hedgehog (HH) signaling might be necessary for ventral midbrain ...Thus, patterning at ... See full document
10
Cholesterol precursors and facial clefting
... low tissue cholesterol levels; however, the accumulating precur- sors ...malformations. Sonic hedgehog and cleft palate The discovery that cholesterol is necessary for the maturation of ... See full document
5
Genomic characterization of Gli activator targets in sonic hedgehog mediated neural patterning
... In this study, we have developed a general approach for detecting targets of Gli transcriptional regulation by ChIP and applied this to a model of Shh-mediated patterning of the developing mammalian neural tube. ... See full document
13
A shared role for sonic hedgehog signalling in patterning chondrichthyan gill arch appendages and tetrapod limbs
... developmental patterning genes between paired and dorsal median fins (Freitas et ...in patterning the endoskeleton of chondrichthyan gill arches points to a common molecular mechanism underlying the axial ... See full document
5
From inflammation to gastric cancer – the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases
... the hedgehog family member sonic hedgehog (SHH) is re- quired to shape the mucosal layer but has to be tightly controlled during the development of the gastric glandu- lar epithelium [135, ...gastric ... See full document
13
Sonic hedgehog controls enteric nervous system development by patterning the extracellular matrix
... and patterning of ENCCs into two ganglionated plexuses within the submucosal and intermyenteric regions of the ...stomach, tissue recombinations showed that removal of the gastric epithelium results in ... See full document
12
Region specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord
... and endocytose this ShhNp from the CSF. These two tentative explanations are not mutually exclusive. Megalin (Lrp2) is a member of the low-density lipoprotein (LDL) receptor-related protein family. Megalin function is ... See full document
11
Splitting the Hedgehog signal: sex and patterning in Drosophila
... Hh signal is ‘corrected’ for the enlarged patterning field, as short-range patterning has to be controlled by ...long-range patterning system of the disc. Augmenting the Hh signal would ... See full document
10
Related subjects