[PDF] Top 20 Pol-Specific CD8+ T Cells Recognize Simian Immunodeficiency Virus-Infected Cells Prior to Nef-Mediated Major Histocompatibility Complex Class I Downregulation
Has 10000 "Pol-Specific CD8+ T Cells Recognize Simian Immunodeficiency Virus-Infected Cells Prior to Nef-Mediated Major Histocompatibility Complex Class I Downregulation" found on our website. Below are the top 20 most common "Pol-Specific CD8+ T Cells Recognize Simian Immunodeficiency Virus-Infected Cells Prior to Nef-Mediated Major Histocompatibility Complex Class I Downregulation".
Pol-Specific CD8+ T Cells Recognize Simian Immunodeficiency Virus-Infected Cells Prior to Nef-Mediated Major Histocompatibility Complex Class I Downregulation
... Target cells were generated from freshly isolated peripheral blood mononuclear cells (PBMC) obtained from SIV-naive Indian rhesus macaques using Ficoll-Paque PLUS (Amersham Biosciences, Uppsala, Sweden) ... See full document
10
Acute Viral Escape Selectively Impairs Nef-Mediated Major Histocompatibility Complex Class I Downmodulation and Increases Susceptibility to Antiviral T Cells
... ef-specific CD8 ⫹ T lymphocytes (CD8TL) are associated with control of both simian immunodeficiency virus (SIV) (1–4) and human immunodeficiency virus type 1 ... See full document
8
Selective Downregulation of Rhesus Macaque and Sooty Mangabey Major Histocompatibility Complex Class I Molecules by Nef Alleles of Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2
... of major histocompatibility complex (MHC) class I molecules by Nef is thought to be an important immune evasion mechanism of human immunodeficiency virus type 1 ... See full document
8
CD8+ Lymphocytes from Simian Immunodeficiency Virus-Infected Rhesus Macaques Recognize 14 Different Epitopes Bound by the Major Histocompatibility Complex Class I Molecule Mamu-A*01: Implications for Vaccine Design and Testing
... CD3 CD8␣ T lymphocytes than the other APC- labeled Mamu-A*01 tetramers ...positive cells differ from those listed in Table 5 because the stains were conducted at different times ... See full document
12
Definition of human immunodeficiency virus type 1 gp120 and gp41 cytotoxic T-lymphocyte epitopes and their restricting major histocompatibility complex class I alleles in simian-human immunodeficiency virus-infected rhesus monkeys.
... human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocytes (CTLs) in controlling virus spread in infected ...individuals. CD8 1 T lymphocytes can ... See full document
6
Detection of simian immunodeficiency virus (SIV)-specific CD8+ T cells in macaques protected from SIV challenge by prior SIV subunit vaccination.
... for CD8 1 cytotoxic T-lymphocyte (CTL) responses to SIV ...exposed prior to challenge, were detected postchallenge in the vaccine-protected animals and persisted for up to 1 ...derived T-cell ... See full document
7
High Viremia Is Associated with High Levels of In Vivo Major Histocompatibility Complex Class I Downregulation in Rhesus Macaques Infected with Simian Immunodeficiency Virus SIVmac239
... node cells ex vivo and evaluation of cell surface marker ...node cells depleted of macrophages, B cells, NK cells, and CD8 ⫹ T cells were gated on lymphocytes by using ... See full document
5
Putative Immunodominant Human Immunodeficiency Virus-Specific CD8+ T-Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype
... gag, pol, env, and nef gene ...18 Pol, 20 Env, and 20 Nef), while the peptide matrix consisted of 20 pools containing up to 10 ...6 cells in all experiments ... See full document
8
Linking Pig-Tailed Macaque Major Histocompatibility Complex Class I Haplotypes and Cytotoxic T Lymphocyte Escape Mutations in Simian Immunodeficiency Virus Infection
... functional T cell assays that a CTL epitope identified in our linkage and sequencing analyses was indeed directed to a Mane-B028-restricted Nef CTL epitope, and (iii) identified Mane-B017-linked mutations ... See full document
16
A Commonly Recognized Simian Immunodeficiency Virus Nef Epitope Presented to Cytotoxic T Lymphocytes of Indian-Origin Rhesus Monkeys by the Prevalent Major Histocompatibility Complex Class I Allele Mamu-A*02
... that recognize this epitope in infected monkeys does not ap- pear to be as high as those that are specific for p11C when assessed by tetramer staining (data not ...the T-cell response to ... See full document
8
Effective Simian Immunodeficiency Virus-Specific CD8+ T Cells Lack an Easily Detectable, Shared Characteristic
... human/simian immunodeficiency virus control remain elusive. While CD8 ⴙ T lymphocytes likely play a major role in reducing peak viremia and maintaining viral control in the ... See full document
12
Use of Major Histocompatibility Complex Class I/Peptide/β2M Tetramers To Quantitate CD8+ Cytotoxic T Lymphocytes Specific for Dominant and Nondominant Viral Epitopes in Simian-Human Immunodeficiency Virus-Infected Rhesus Monkeys
... SIVmac Pol and HIV-1 Env epitopes in the present study confirms the predicted importance of proline as the position 3 anchor ...SIVmac Pol p68A (threonine at P2, proline at P3, and proline at P4) and HIV-1 ... See full document
7
Simian and Human Immunodeficiency Virus Nef Proteins Use Different Surfaces To Downregulate Class I Major Histocompatibility Complex Antigen Expression
... downregulate class I major histocompatibility complex (MHC) and CD4 expression on the cell surface and to alter T-cell-receptor-initiat- ed signal transduction in T ... See full document
11
Simian Immunodeficiency Virus-Specific CD8+ T Cells Recognize Vpr- and Rev-Derived Epitopes Early after Infection
... Vpr-specific CD8 ⴙ T cells recognize simian immunodefi- ciency virus (SIV)-infected cells early after ...of CD8 ⫹ T cell epitopes derived from ... See full document
6
Control of Simian Immunodeficiency Virus Replication by Vaccine-Induced Gag- and Vif-Specific CD8+ T Cells
... effective T cell-based AIDS vaccine, it is critical to define the antigens that elicit the most potent re- ...Vif/Nef-specific CD8 ⴙ T cells can be important in control of the ... See full document
9
Detection of Simian Immunodeficiency Virus Gag-Specific CD8+ T Lymphocytes in Semen of Chronically Infected Rhesus Monkeys by Cell Staining with a Tetrameric Major Histocompatibility Complex Class I-Peptide Complex
... the infected monkeys ...granulocytic cells; microscopic examination confirmed the presence of neutrophils, in addition to lymphocytes and macrophages, in this specimen (data not ... See full document
5
ALVAC-SIV-gag-pol-env-Based Vaccination and Macaque Major Histocompatibility Complex Class I (A*01) Delay Simian Immunodeficiency Virus SIVmac-Induced Immunodeficiency
... ALVAC-SIV-gpe. T-cell-mediated cytolytic activity was assessed in the blood of six of the immu- nized animals in each group as well as in control animals from group E following the third, fourth, and last ... See full document
11
Impact of Nef-Mediated Downregulation of Major Histocompatibility Complex Class I on Immune Response to Simian Immunodeficiency Virus
... the nef sequence variation in the four animals infected with the MHC-selective mutants was that many of the variations changed the amino acid to that observed in the consensus sequence for the Nef ... See full document
10
Transcriptionally Abundant Major Histocompatibility Complex Class I Alleles Are Fundamental to Nonhuman Primate Simian Immunodeficiency Virus-Specific CD8+ T Cell Responses
... we infected M3 MCMs and scanned the entire SIV proteome by IFN- ␥ ELISPOT assay with overlapping peptide pools (Table ...SIV-specific CD8 ⫹ T cell responses were transcrip- tionally abundant ... See full document
12
Mauritian Cynomolgus Macaques Share Two Exceptionally Common Major Histocompatibility Complex Class I Alleles That Restrict Simian Immunodeficiency Virus-Specific CD8+ T Cells
... SIV-specific CD8 T-cell re- sponses in ...-A*29 CD8 ⫹ T-cell epitopes by scanning the SIV proteome for variation in chronically infected MCM (data not shown) and comparing these ... See full document
9
Related subjects