[PDF] Top 20 STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE
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STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE
... Both GM-CSF single and triple cytokine-producing CD4 T cells were recently described in MS patients [40], but the ontogeny of these effector cell populations and how these cells ... See full document
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BJ-1108, a 6-Amino-2,4,5-trimethylpyridin-3-ol analogue, regulates differentiation of Th1 and Th17 cells to ameliorate experimental autoimmune encephalomyelitis
... Although Th1 cells are considered to be the primary effector T cells in EAE pathology, EAE can occur in IFN-γ knock- out mice ...that Th17 cells that secrete IL-17 and ... See full document
11
IL-23R–activated STAT3/STAT4 is essential for Th1/Th17-mediated CNS autoimmunity
... enhances Th17 cell differentiation. STAT3 binds to several Th17-as- sociated genes, including Il17, Il21, Il23r, and Rorc locus (54, ...T cells suggest that IL-23 signaling is associated with an ... See full document
21
Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties
... on Th1 and Th17 cells in MS pathogenesis has come mainly from EAE models where individual antigen-specific Th1 and Th17 cells were adoptively transferred into the ...T ... See full document
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Aging diminishes the resistance of AO rats to EAE: putative role of enhanced generation of GM-CSF Expressing CD4+ T cells in aged rats
... T cells play a central role in initiating and orchestrating CNS inflammation ...MS. EAE can be actively induced in susceptible strains of mice and rats by immunization with either whole spinal cord ... See full document
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The NF κB regulator MALT1 determines the encephalitogenic potential of Th17 cells
... (CARD11), B cell lymphoma-10 (BCL10), and MALT1 proteins and is required for activation of downstream canonical NF-κB sig- naling (22). In addition to this scaffolding function, MALT1 has paracaspase activity that ... See full document
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IKKβ-mediated inflammatory myeloid cell activation exacerbates experimental autoimmune encephalomyelitis by potentiating Th1/Th17 cell activation and compromising blood brain barrier
... mice, Th1 and Th17 cells increased to only ...Th cells to Th17 cells), and IL-17 in the EAE-induced spinal cord was markedly reduced by myeloid IKKβ deletion ...Th2 ... See full document
21
Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells
... T cells isolated from mouse spleens were induced to differentiate into Th1 or Th17 cells and co-cultured with MSCs added at day 0, 2 or 4 of the differentiation ...T cells labeled with ... See full document
12
Increased IFN-γ-producing Th17/Th1 cells and their association with lung function and current smoking status in patients with chronic obstructive pulmonary disease
... cing production of a variety of chemokines, such as IL-1β, IL-6, TNF-α, CXCL8, granulocyte colony-stimulating fac- tor (G-CSF), and GM-CSF from inflammatory and struc- tural cells of ... See full document
9
Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus
... T cells [10-12], as well as by CD3 + CD4 - CD8 - (double negative or DN) T cells and NK cells ...IL-8, GM-CSF, G- CSF), chemokines (CXCL1, CXCL10), and metallopro- teinases ...of ... See full document
10
Cardiac myosin-Th17 responses promote heart failure in human myocarditis
... the Th17 response in human myocarditis/DCM, Tregs were found to be significantly ...the Th17 subset was elevated and associated with elevated levels of the proinflammatory cytokines IL-17, IL-6, IL-23, and ... See full document
20
Anti Allergic Effect of Para Probiotics from Non Viable Acetic Acid Bacteria in Ovalbumin Sensitized Mice
... Cytokine production by OVA-stimulated splenocytes from OVA-sensitized mice without and with oral administration of ...splenic cells under the conditions mentioned in material and ... See full document
10
Reactivation of Latent Human Cytomegalovirus in CD14+ Monocytes Is Differentiation Dependent
... The cells were washed in PBS, fixed in phosphate-buffered 1% paraformaldehyde or methanol- acetone (1:1) for 10 min at room temperature, and permeabilized with ...PBS. Cells were blocked with 10% normal ... See full document
12
Barthels, Christian (2016): CD40 signaling in dendritic cells modulates tolerance and immunity. Dissertation, LMU München: Medizinische Fakultät
... OTI cells was only observed in the case of control animals immunized with Ova and anti-CD40 ...T cells, splenocytes loaded with the peptide recognized by OTI and unloaded control splenocytes were transfered ... See full document
113
Characterization of leukotrienes in a pilot study of older asthma subjects
... Despite older asthmatics often having more severe dis- ease and exacerbations, few studies have been done to characterize their asthma at a cell and/or molecular level. We have previously shown that functional ... See full document
6
Crohn’s Disease: a Role of Gut Microbiota and Nod2 Gene Polymorphisms in Disease Pathogenesis
... on both chromosomes in the absence of disease (32) and also mice deficient in Nod2 do not develop CD spontaneously ...healthy controls of CARD15 mutations associated with Crohn’s disease is 20% ... See full document
8
Poly(ADP-ribose) polymerase 2 contributes to neuroinflammation and neurological dysfunction in mouse experimental autoimmune encephalomyelitis
... rodent EAE [10-12] but it is not yet clear what the relative contributions of PARP-1 and PARP-2 are to this ...in EAE has produced disparate results, both mitigating [13] and en- hancing [14] ... See full document
7
Original Article Imbalance of Th1/Th2 and Th17/Treg during the development of uterine cervical cancer
... the Th17 secreted cytokines (IL-17 and IL-23) and Treg secreted cytokines (TGF-βI and IL-10) were all significantly higher in the UCC group than the control ...the Th1 and Th2 representative cytokines INF-γ ... See full document
9
Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis
... In the pathogenesis of MS, two mutually complementary processes can be identified: autoimmune inflammation is more pronounced at the initial stages of the disease, while axonal neurodegeneration is observed in advanced ... See full document
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Gilz-Activin A as a Novel Signaling Axis Orchestrating Mesenchymal Stem Cell and Th17 Cell Interplay
... in Th17 cells and inhibition of IL-17, switching the differentiation of the pro-inflammatory Th17 lineage toward a Treg cell phenotype and ...T cells, suggests a new paradigm of ... See full document
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