[PDF] Top 20 Stem cell metabolism in tissue development and aging

... on stem cell metabolism is based on steady-state measurements of lyzed ...in stem cell metabolism is the current lack of reliable methods for metabolomic profiling at the ... See full document

... epiblast stem cells (EpiSCs), which are derived from a post-implantation epiblast at a later stage of development (Zhou et ...mitochondrial metabolism in the maintenance of mESCs (Zhou et ... See full document

... mesenchymal stem cells offer an attractive high throughput screening platform for new target/ drug ...These stem cells can be readily expanded in vitro and can be isolated from a variety of tissue ... See full document

... in metabolism, detoxification, and protein ...major cell type in the liver, execute most of the metabolic, synthetic and storage functions of the ...that stem cells could be an alternative ... See full document

... in stem cell aging (Table ...various cell-extrinsic signals, as the fundamental ma- chinery controlling the properties of TSCs, and miR-17 family members are key regulators in this context ... See full document

... Fig. 4. SP cells and ABCG2 expression in the human limbo-corneal epithelium. Human corneas unsuitable for human transplant were ob- tained from the National Disease Research Interchange. (A) Flow cytometry blue/red ... See full document

... Recent studies have shown that the human placenta also functions as a hematopoietic organ throughout gestation (Barcena et al., 2009a; Barcena et al., 2009b; Robin et al., 2009). Similar to the mouse placenta, the human ... See full document

... 1)“TISSUE STEM CELLS” - also sometimes called adult stem cells because each type of adult stem cell produces only a limited set of specialized cells characteristic of a particular ... See full document

... mesenchymal stem cells (MSCs) through the delivery of regulatory genes is a promising strategy in tissue engineering ...modulating stem cell fate after reporter and therapeutic gene ...the ... See full document

... of metabolism that, by 1931, Joseph Needham ’ s book Chemical Embryology exceeded 2000 pages (Needham, ...‘ Metabolism in Time and Space ’ , which heralded the return of this long-neglected pillar of ... See full document

... resident stem cells. Adult stem cells are characterized by the ability to self-renew and differentiate into multiple cell types within a ...that stem cells are nonetheless susceptible to ... See full document

... in aging cells and tissues DNA methylation was first measured globally using biochemical methods, and early studies showed progressive depletion of 5­meth­ ylcytosine associated with in vitro senescence in normal ... See full document

... with aging, it will indirectly accelerate age-related changes by exposing cells to various cellular stresses including oxida- tive ...with aging [21] ...the development of ARHL ...the ... See full document

... A 669 bp fragment in the coding region of HAL1 and HAL2 cDNA was PCR amplified using the following primers: HAL1 forward 5′ACTGTTCCATGTAAAGA TGCTTGTG 3′, HAL1 reverse 5′ AGCATCAATAG CTTGTTGTAACG 3′; HAL2 forward 5′ GCCGT ... See full document

... develop tissue engineering scaffolds consisting of self-assembling KLD-12 polypeptide/ TGF-β1 nanofiber gel, for the induction of mesenchymal stem cell (MSCs) differentiation into nucleus pulposus ... See full document

... of cell metabolism has evolved into an active area of research during the last decade, with a strong focus on glucose ...hepatic tissue due to their elevated lysine catabolism, which reduces ROS ... See full document

... of cell metabolism has evolved into an active area of research during the last decade, with a strong focus on glucose ...hepatic tissue due to their elevated lysine catabolism, which reduces ROS ... See full document

... of stem cells decline with age, thereby undermining endogenous repair ...the aging-induced deterioration of stem cell function may play a key role in the pathophysiology of various ... See full document

... a stem cell pool by fine-tuning cellular states balance between self-renewal and ...a stem cell ...in stem cell transition and homeostasis, highlight- ing the importance of ... See full document

... The second interesting aspect is the relationship between CD34 and hypoxia. Since CD34 might be a niche-specific marker of progenitors, it can be specu- lated that hypoxic conditions might have something to do with its ... See full document