[PDF] Top 20 Strategies targeting cellular senescence
Has 10000 "Strategies targeting cellular senescence" found on our website. Below are the top 20 most common "Strategies targeting cellular senescence".
Strategies targeting cellular senescence
... immune-boosting strategies, a growing arsenal of tools such as chi- meric antigen receptor (CAR) T cells provide the option to redirect immune responses against senescent cells ...notherapy-based targeting. ... See full document
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miR-34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c-Myc pathway
... Increasing evidence suggests that miRNAs can act as either tumor suppressors or oncogenes in carcinogenesis. In the present study, we identified the role of miR-34a in regulating telomerase activity, with subsequent ... See full document
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Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives
... At first, it will be extremely difficult to justify the use of seno- lytic molecules outside the context of a clear disease as a preven- tion strategy to delay various diseases associated with senescent cell ... See full document
10
Potential role of cellular senescence on coronavirus infections
... therapeutic strategies to combat the ...replication, cellular senescence related to aging, obesity, and diabetes appears to be strongly correlated with the SARS- CoV-2 infections resulting in higher ... See full document
12
Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells
... that cellular senescence occurred at 24 h and peaked at 72 h after MLN8237 ...undergo cellular senescence and growth inhibition due to AURKA ... See full document
16
Coming of age: molecular drivers of aging and therapeutic opportunities
... in cellular immunity is one of the most clinically famil- iar and morbid features of human ...the cellular immune system including HSCs, thy- mus, and B and T ...of senescence induction, whereas the ... See full document
6
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
... Interventions targeting cellular senescence and the SASP Potential strategies for mitigating the deleterious effects of senes- cent cells include interfering with pathways that lead to senes- ... See full document
8
The ING tumor suppressors in cellular senescence and chromatin
... The developmental and physiological functions of ING1 and ING2 in vivo have been investigated by manipulat- ing endogenous ING genes. Several mouse models with deficiency in the ING1 locus have been described [19,22]. ... See full document
6
THE RELEVANCE OF MICRORNAS IN VASCULAR AGING
... functions, cellular senescence, apoptosis and various cellular metabolisms through its interaction with a number of molecules, including Ku70, p53, PML and FOXO ... See full document
6
Cooperative Effects of Akt-1 and Raf-1 on the Induction of Cellular Senescence in Doxorubicin or Tamoxifen Treated Breast Cancer Cells
... [66-73]. Targeting the PI3K/PTEN/Akt/ mTOR pathway may prove effective therapy in a variety of cancers ...of targeting mTOR in PTEN- negative cells ...of targeting mTOR with rapamycin is that it has ... See full document
17
Cellular senescence in cancer treatment: friend or foe?
... by strategies including immunothera- py, gene therapy, inhibition of angiogenesis, hyperther- mia, and a number of novel lesion-based approaches such as the administration of the Bcr-Abl kinase inhibitor STI-571, ... See full document
7
Jumonji C Demethylases in Cellular Senescence
... In search for an alternative to N-oxalyglycine, a potent inhibitor, N-oxalyl-D-tyrosine was found to inhibit KDM4 and KDM5 subfamilies. N-oxalyl-D-tyrosine is a derivative of D- tyrosine and binds to the active site of ... See full document
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<p>The cGAS/STING pathway: a sensor of senescence-associated DNA damage and trigger of inflammation in early age-related macular degeneration</p>
... treatment strategies that modulate the complement system in AMD are being inves- ...by targeting various effectors molecules, such as C3, C5, and factor ... See full document
7
Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α
... and targeting PRMT5 activity with DW14800 significantly reduced the self-renewal capability of ...cell senescence and apoptosis of HCC cells, indicating that targeting undifferentiated cancer cells ... See full document
12
Induction of Cellular Senescence As A Novel Therapeutic Strategy for Melanoma Treatment
... CTX-induced senescence (Chien et ...of senescence that was NF-ĸB ...dependent senescence mechanisms attributed to patients’ survival (Jing et ...therapy-induced senescence in cancer cells, ... See full document
146
When cells get stressed: an integrative view of cellular senescence
... replicative senescence and stress-induced senescence serve the same biological function, and which of these mechanisms operates in vivo (10, 11, ...replicative senescence exhibited by some types of ... See full document
7
Haplo-insufficiency of both BubR1 and SGO1 accelerates cellular senescence
... divide. Senescence is the main risk factor for age-related disorders including diabetes, atheroscler- osis, hypertension, osteoarthritis, and Alzheimer ’ s dis- ease and Parkinson ’ s disease ...of ... See full document
6
Irreversibility of cellular senescence: dual roles of p16INK4a/Rb-pathway in cell cycle control
... and is no longer revoked by subsequent inactivation of pRb and p53 [13-15]. Interestingly, subsequent inactiva- tion of pRb and p53 enables human senescent cells to reinitiate DNA synthesis but fails to drive the ... See full document
5
Effect of Hypoxia on the Induction of Premature Cellular Senescence in the Cells of Periodontium during Orthodontic Tooth Loading
... (cellular senescence) is a permanent state of cell cycle arrest. Senescence deteriorates the life cycle of cells [15], suppresses new DNA or collagen formation and limit cells migration ...the ... See full document
5
Suberoylanilide hydroxamic acid represses glioma stem-like cells
... Fig. 1 Serum-free suspension culture induces the enrichment of Glioma stem-like cells (GSCs). a and b GSCs from U87MG GBM cells were grown in serum-free DMEM/F12 medium/suspension culture for 2 – 14 days. Sphere ... See full document
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