[PDF] Top 20 Structural basis of human kinesin 8 function and inhibition
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Structural basis of human kinesin 8 function and inhibition
... different structural mechanism for MT depolymerization was recently proposed for the kinesin-8 Kif19A (involved in length regulation of primary cilia) involving large-scale unfolding of the Kif19A ... See full document
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Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus
... our structural studies on protease-inhibitor complexes, we have shown that the mechanism of inhibition involves covalent bond formation with the sulfhydryl of the conserved cysteine in the active site by ... See full document
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Structural Basis for the Inhibition of Host Gene Expression by Porcine Epidemic Diarrhea Virus nsp1
... nsp1 inhibition of host gene expression remain ...detailed structural basis through which PEDV nsp1 inhibits host gene expression, providing insight into the development of a new attenuated vaccine ... See full document
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Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment.
... as human NDR1 and NDR2 were shown to phosphorylate the Yorkie ortholog YAP1 both in vitro and in vivo, allowing them to function as tumor suppressors in the intestinal epithelium (Tang et ... See full document
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Structural Basis for Norovirus Inhibition and Fucose Mimicry by Citrate
... the structural basis by which citrate binds to the HBGA binding site of the norovirus ...the structural basis for norovirus interaction with ci- trate as revealed here may be helpful in such ... See full document
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Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin
... An analysis of deduced amino acid sequences of LspAs from 485 organisms having between 35% and 95% sequence identity with the signal peptidase II of PAO1 identified fourteen strictly conserved residues (D23, K27, N54, ... See full document
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Structural Basis of the Inhibition of STAT1 Activity by Sendai Virus C Protein
... tion. Crystals suitable for diffraction analysis were obtained by the micro- seeding technique. Diffraction intensities of the crystals were determined using synchrotron radiation from BL38B1 at SPring-8 (Harima, ... See full document
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Structural Basis for the Inhibition of the Chromatin Repressor BAHD1 by the Bacterial Nucleomodulin LntA
... IMPORTANCE Pathogens have evolved various strategies to deregulate the expression of host defense genes during infection, such as targeting nuclear proteins. LntA, a secreted virulence factor from the bacterium Listeria ... See full document
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Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides
... In order to better understand the 2=FL and 3FL binding inter- actions from a structural perspective, we solved the X-ray crystal structures of the GII.10 P domains in complex with 2=FL and 3FL. The GII.10 P domain ... See full document
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Structural basis for the inhibition of HIV 1 Nef by a high affinity binding single domain antibody
... sdAb19 binding and the ability of Nef to downregulate CD4. Nef(K148E), which was still able to bind sdAb19 but with a lower affinity (see Figure 4E), was functionally inhib- ited by Neffin only when high levels of Neffin ... See full document
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Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93
... the structural proteins VP4 to VP1 from P1 and the nonstructural proteins associated with replication, 2A to 2C and 3A to 3D from P2 and P3, respectively, from the N to the C terminus ... See full document
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Design, Synthesis, Characterization and Biological Evaluation of Some Novel 3, 4-Dihydropyrimidin-2(1h)-One as Anti Tubercular Agents.
... Batt, et al., 2012 Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors.[14] The following works throws a light upon the various genomic aspec[r] ... See full document
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Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates
... the structural basis of bicyclic boronate inhibition of class A, B and D -lactamases, biophysical studies including crystallographic analysis of a bicyclic boronate in complex with the clinically ... See full document
13
Structural Basis of Human Parechovirus Neutralization by Human Monoclonal Antibodies
... that human parechoviruses (HPeV) are a significant cause of central nervous system and neonatal sepsis, their clinical importance, primarily in children, has started to ...Direct inhibition of parechovirus ... See full document
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Rummel, David (2006): Correction for covariate measurement error in nonparametric regression. Dissertation, LMU München: Fakultät für Mathematik, Informatik und Statistik
... Mostly, the type of functional relationship between independent and depen- dent variables in a regression context is hardly to predict a priori. A rea- sonable strategy lies then in adopting such a type of regression ... See full document
249
The potential of different Autotaxin inhibitor types regulating catalysis-dependent and -independent signalling
... Type I inhibitors would effectively stop LPA production from LPC, but would not affect any independent function of the allosteric site. Type IV inhibitors however, would also abolish any functionality of the ... See full document
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Extending the neurocircuitry of behavioural inhibition: a role for the bed nucleus of the stria terminalis in risk for anxiety disorders
... Behavioural inhibition represents the most extreme 15% on a continuum of reactivity to novelty and many, but not all, children with behavioural inhibition develop anxiety disorders later in ... See full document
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Dual Function During Development of Rat Sympathetic Neurones in Culture
... The transmitter status of a neurone can be assayed by recording its effect on the myocytes adrenergic excitation, cholinergic inhibition or dual function; then a fine structural assay of[r] ... See full document
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Human recombinant antibody fragments neutralizing human immunodeficiency virus type 1 reverse transcriptase provide an experimental basis for the structural classification of the DNA polymerase family.
... infection, 5 PFU of each virus per cell) and harvested 72 h later. After being washed with phosphate-buffered saline (PBS), cell pellets were resuspended in 30 ml of ice-cold extraction buffer (EB) (20 mM Tris [pH 8.0], ... See full document
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Thiazolidinone CFTR inhibitor identified by high throughput screening blocks cholera toxin–induced intestinal fluid secretion
... In addition to pharmacological creation of the CF phenotype, high-affinity CFTR inhibitors have poten- tial clinical applications in the therapy of secretory diar- rheas and cystic kidney disease, and in inhibiting male ... See full document
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