[PDF] Top 20 Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus
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Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus
... the substrate. In both TALE- and INFE-bound NV protease struc- tures, the C-terminal tail, representing P4 to P1 in two of the NV polyprotein sites, adopts a very similar extended -conformation, such that ... See full document
12
Structural Basis for the Receptor Binding Specificity of Norwalk Virus
... the structural basis for differences in ligand recognition of noroviruses from different genogroups, the prototypic Norwalk virus (NV; GI-1) and VA387 (GII-4), which recognize the same A ... See full document
8
Alteration of Substrate and Inhibitor Specificity of Feline Immunodeficiency Virus Protease
... of substrate specificity using RSV and HIV-1 proteases have been published (3, 11, 12, ...with substrate specificity were identified and an RSV mutant protease (S9) was engineered to ... See full document
11
Molecular Determinants of Substrate Specificity for Semliki Forest Virus Nonstructural Protease
... peptide substrate (see ...non- structural protease specifically recognizes at least five residues, four of them lying on the N-terminal side of the cleavage ... See full document
10
Altered Substrate Specificity of Drug-Resistant Human Immunodeficiency Virus Type 1 Protease
... immunodeficiency virus type 1 protease (HIV PR) inhibitors results primarily from the selection of multiple mutations in the protease ...affect substrate binding and potentially ... See full document
10
Probing the substrate specificity of hepatitis C virus NS3 serine protease by using synthetic peptides.
... NS3/4A protease in trans-cleav- age ...The substrate specificity study described in this paper, together with crystal structure information, provide the preliminary basis for the rational ... See full document
6
Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93
... the virus was removed and serial dilutions of one com- pound per plate were ...This virus was used for successive rounds of infection, a procedure that was repeated 15 times in order to generate drug- ... See full document
10
X-Ray Crystallographic Structure of the Norwalk Virus Protease at 1.5-Å Resolution
... Chiba virus proteases, using a triad versus a dyad, respectively, is surprising considering that both of these viruses are from the same geno- group, with 91% aa identity in the protease sequence, and that ... See full document
9
Structural Basis for Distinctions between Substrate and Inhibitor Specificities for Feline Immunodeficiency Virus and Human Immunodeficiency Virus Proteases
... immunodeficiency virus (FIV) protease (PR) as a mutational framework to define determi- nants for the observed substrate and inhibitor specificity distinctions between FIV and human ... See full document
12
Changing the Protease Specificity for Activation of a Flavivirus, Tick-Borne Encephalitis Virus
... typical substrate for chymotrypsin, the position of this selected mutation three residues upstream from the natural cleavage site was ...large structural reor- ganization required for the conversion to ... See full document
11
Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides
... 2008. Structural basis for the receptor binding specificity of Norwalk ...2012. Structural basis for the recognition of Lewis antigens by genogroup I ... See full document
6
Structural and Thermodynamic Basis for the Binding of TMC114, a Next-Generation Human Immunodeficiency Virus Type 1 Protease Inhibitor
... the virus becomes resistant to the ...mutations, substrate binding may also be ...of substrate sites would be required for the virus to ...V82A protease drug-resistant mutation (14, 21, ... See full document
10
Structural and functional basis of protein phosphatase 5 substrate specificity
... Cdc37 substrate with the PPP Ser/Thr phosphatase ...the substrate is primarily dictated by interac- tions between its backbone and residues of PP5 that line the active ...Cdc37 substrate and PP5 are ... See full document
15
Molecular Basis for the Relative Substrate Specificity of Human Immunodeficiency Virus Type 1 and Feline Immunodeficiency Virus Proteases
... Substrates were selected from the library that were cleaved by FIV PR. Cleaved phage were individually regrown and screened with wt HIV-1 PR and FIV PR, along with phage clones that were previously selected by a screen ... See full document
12
Structural Basis of the Inhibition of STAT1 Activity by Sendai Virus C Protein
... The structure of the STAT1:STAT2 heterodimer remains un- known. Assuming that the behavior of the STAT1:STAT2 het- erodimer is similar to that of the STAT1 homodimer, the C pro- tein appears to bind to the molecular ... See full document
13
Structural Requirements for the Assembly of Norwalk Virus-Like Particles
... 2002 Norwalk virus (NV) is the prototype strain of a group of human caliciviruses responsible for epidemic outbreaks of acute ...NV virus-like particles (rNV VLPs) that are morphologically and ... See full document
12
Evolutionary Selection on Barrier Activity: Bar1 Is an Aspartyl Protease with Novel Substrate Specificity
... aspartyl protease that acts as a “barrier” and antagonist to pheromone signaling in multiple ...that protease substrate specificity co- evolved along with changes in its pheromone ...the ... See full document
12
Structural Analysis of Human Immunodeficiency Virus Type 1 CRF01_AE Protease in Complex with the Substrate p1-p6
... 2C). The collapse of the flap hinge toward the core is further enhanced by the formation of a hydrogen bond between the carbonyl oxygen of Asp35 and the NE or NH-2 of the Arg20 side chain. This interaction causes the ... See full document
5
Structural Basis for the Inhibition of Host Gene Expression by Porcine Epidemic Diarrhea Virus nsp1
... nsp1 inhibition of host protein synthesis have been deeply ...hepatitis virus (MHV) nsp1 enhances the virulence of the virus by efficiently interfering with the type I IFN system ...nsp1 ... See full document
14
Substrate specificity of recombinant human immunodeficiency virus integrase protein.
... Since none of the single nucleotide substitutions or clustered base changes outside the conserved CA motif had dramatic ef- fects upon cleavage and all retroviral termini share this moti[r] ... See full document
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