[PDF] Top 20 The Subunit Structure of Normal and Hemophilic Factor VIII
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The Subunit Structure of Normal and Hemophilic Factor VIII
... Human factor VIII from normals and hemophiliacs was partially purified by ethanol and polyethylene glycol ...from normal and hemophilic plasma following the agarose chromatography ...purified ... See full document
14
Interaction of factor VIII antigen in hemophilic plasmas with human antibodies to factor VIII
... from hemophilic plasmas with immobilized rabbit antibody which reacted with normal VIIIc and von Willebrand's disease ...between normal and hemophilic Factor VIII than previously ... See full document
7
Defective alpha polymerization in the conversion of fibrinogen Baltimore to fibrin
... subunit structure. alpha-polymers were not generated in thrombin-induced, factor XIII-rich clots of fibrinogen Baltimore under conditions of pH and calcium concentration suitable for complete ... See full document
6
The effect of fibrin stabilizing factor on the subunit structure of human fibrin
... fibrin-stabilizing factor forms clots lacking the cross links among the a- and gchains found in normal, cross-linked human ...fibrin-stabilizing factor or normal plasma to the deficient plasma ... See full document
9
ENZYMES AND BLOOD CLOTTING I TRYPSIN AS AN ACCESSORY FACTOR
... time PT, after Quick, Stanley-Brown and Bancroft 12; 4 Ca-cephalin-plasma clotting time PTT, after Langdell and co-workers 13, using substrate plasmas from a normal N, b hemophilic VIII-[r] ... See full document
12
Disulfide Bonds and the Quaternary Structure of Factor VIII/von Willebrand Factor
... chromatography and 4% agarose gel filtration was subjected to sodium dodecyl sulfate gel electrophoresis on gels containing 2% acrylamide and 0.5% agarose. We find a series of multimers of which the apparent molecular ... See full document
9
Studies on human antihemophilic factor Evidence for a covalently linked subunit structure
... Willebrand factor activity remained coincident in the void volume; however, most of the remaining procoagulant activity was eluted after the void ...of Factor VIII procoagulant activity from 4% ... See full document
14
Immunoradiometric measurement of the factor VIII procoagulant antigen
... immunologically detectable protein in normal and von Willebrand's disease plasmas. In contrast, several different patterns have been identified in hemophilic plasmas. Neither procoagulant activity nor ... See full document
6
Acquired factor VIII inhibitor and lupus anticoagulant presenting with prolonged aPTT: a case report
... of factor VIII inactivated by the patient’s plasma incubated with normal plasma under specific ...of factor VIII in a 1:1 mixture of the patient’s plasma and normal plasma (after ... See full document
6
Subunit structure of factor VIII antigen synthesized by cultured human endothelial cells
... The Factor VIII antigen synthesized by cultured endothelial cells was found to contain the same single polypeptide subunit (mol wt 225,000) present in plasma Factor VIII ...circulating ... See full document
6
Factor VIII bypassing activity of bovine tissue factor using the canine hemophilic model
... coagulation factor, factor VIII, is frequently complicated by the development of neutralizing ...tissue factor, a known initiator of coagulation, was investigated as a factor ... See full document
7
Studies on the Nature of Antihemophilic Factor (Factor VIII): FURTHER EVIDENCE RELATING THE AHF LIKE ANTIGENS IN NORMAL AND HEMOPHILIC PLASMAS
... in normal and hemophilic plasma but deficient in severe von Willebrand's disease ...in normal plasma, and this property was removed by absorption of the antisera with concentrates of normal or ... See full document
8
Carrier Detection in Classical Hemophilia
... This factor VIII antigen (present in normal, carrier, and hemophilic plasma) is in excess of the factor VIII procoagulant activity in 80Yo to 90% of carriers, in contrast to approxi- mat[r] ... See full document
6
Factor structure, reliability, and validity of the Japanese version of the Hoarding Rating Scale-Self-Report (HRS-SR-J)
... consists of one factor. In addition, no information exists about its test–retest reliability, and publishing its test–retest data so that users know the level of stability they can rely on is needed. Moreover, ... See full document
9
Factor structure of the Persian version of general, social, and negative self-consciousness of appearance domains of Derriford Appearance Scale 59: an application in the field of burn injuries
... The factor structure had acceptable eigenvalues ...exploratory factor analysis recognized three subscales that can be used to differentiate between various manifestations of disfigurement due to burn ... See full document
8
Prevalence of factor VIII inhibitors in haemophilia a patients who received factor VIII therapy
... Less frequent exposure to FVIII concentrate in patients with mild haemophilia accounted for a lower incidence of inhibitor development CANAL study ,dose of 35 -50 IU/kg over five consecutive days was associated with 1.4 ... See full document
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THE PERPETUATION OF HEMOPHILIA BY MUTATION
... Fic. I)istribution of Factor VIII levels in mothers of severe sporadic cases of hemophilia A compared to con-. brined female carriers and normal women.[r] ... See full document
10
The structure and function of vertebrate fibroblast growth factor receptor 1
... been found in the extracellular matrix and in blood where they may function to regulate the biological activities of the FGFs during cell proliferation and development (Hanneken, 2001; and see below). Several groups have ... See full document
8
Role of human factor VIII in factor X activation
... human Factor VIII in Factor X activation was investigated by an initial-rate assay of 3H-Factor X activation in the presence of human factor IXa, Ca2+, and either phospholipid or fresh ... See full document
10
Recombinant Factor VIII versus plasma derived Factor VIII in the management of haemophilia A: an examination of the costs and consequences
... Much of the literature focusing on viral transmission refers to risks associated with ‘unknown’ or future viruses. The issue of ‘unknown risk’ is a very subjective concept and can only be assessed based on known risk and ... See full document
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