[PDF] Top 20 Systematic review of methods for individual patient data meta- analysis with binary outcomes

... IPD meta-analysis of binary ...of systematic reviews and meta-analyses, these guidelines are not specific to ...the methods of handling data and combining results, ... See full document

... collection, data management and confidentiality The individual patient data provided by the Collaborators will be de-identified, re-coded as required and stored in a custom-designed Microsoft ... See full document

... and data completeness, to inform the selec- tion of a modelling ...descriptive analysis will be undertaken to understand similarities and differences between the contributing ...non-parametric ... See full document

... A meta-analysis showed iNO improved oxygenation in approximately 50% of full term or near term infants with pulmonary hyper- tension and hypoxic respiratory ...different outcomes assessed ... See full document

... We assessed the study quality as per Cochrane guide- lines 12 (see online supplementary table S4). All studies described a randomisation sequence generation tech- nique that was at low risk of bias except one that had an ... See full document

... on outcomes of be- haviour, prompts/cues and instruction on how to perform a behaviour are examples of behaviour change tech- niques commonly used to facilitate a behaviour change in healthcare workers [17, ... See full document

... An individual patient data meta-analysis of three randomized trials of routine versus selective invasive strategies in patients with non-ST-segment elevation acute coronary syndrome ... See full document

... RJC, JAS, KT, and RNP conceived the study, analysed and interpreted the data, and drafted the manuscript. RJC, GSH, PD, CHS, PJG, and KSt provided technical support and undertook pooling of patient ... See full document

... relevant outcomes across ...of outcomes reported but also on how these were collected across ...this analysis the primary out- come of each study was used to generate patient-level ... See full document

... of Systematic Reviews, Cochrane Central Register of Con- trolled Trials, Health Technology Assessment Database, Database of Abstracts of Review of Effects, BIOSIS Previews, Science Citation Index Expanded, ... See full document

... surrogate outcomes reflecting GD activity include liver and spleen volume, hemoglobin concentration, platelet count, and symptomatic bone events with imaging ...predicting outcomes will be reported as ... See full document

... extracted data on general study characteristics, intervention and con- trol characteristics, potential effect modifiers, outcomes and risk of bias using a piloted data collection ...For binary ... See full document

... Estimation of GLMMs with binary outcomes con- tinues to pose challenges, with many methods producing biased regression coefficients and variance components [7]. AGHQ has been shown to overestimate ... See full document

... These systematic reviews represent the best attempts to integrate evidence of prognostic factors to date, [6,8] but the findings are compromised because authors of some primary studies report adjusted estimates ... See full document

... and patient subgroups, nor effects on longer-term clinical ...While systematic review and meta-analysis can help establish generalisability and overall effectiveness, individual ... See full document

... the Patient Research Partners and research- ers ...the Patient Research Partners and researchers to inform our future ...the Patient Research Partners and the re- searchers completed a short ... See full document

... International expert committees, including the American and Canadian Diabetes Association, and the European Association for the Study of Diabetes, recom- mend that insulin regimens are tailored to the indivi- dual ’ s ... See full document

... an individual patient data meta-analysis Individual patient data meta-analysis (IPDMA) is consid- ered to be the least biased method and ‘gold ... See full document

... the analysis was undertaken separately, stratifying by relapse ...sensitivity analysis, there was minimal bias related to individual study sites (S8 ...subgroup analysis of the two studies ... See full document

... aggregate data from their study publications (such aggregate data has already been extracted from our previous HTA re- ...two-step meta-analysis framework, combine the IPD trials with the ... See full document