[PDF] Top 20 Systemic lupus erythematosus and the type I interferon system

... interferogenic ICs (IICs) can all trigger NIPCs/PDCs to produce IFN- α . Fc γ RIIa is necessary for the activation of NIPCs/PDCs by IICs. In addition, these cells express Toll-like receptor 9 (TLR9), mediating IFN- α ... See full document

... ACR criteria, had a clinical SLE diagnosis with at least two organ manifestations characteristic of SLE, autoim- mune phenomena and no other diagnosis that could better explain the symptoms. The median Systemic ... See full document

... ABSTRACT Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disease in humans and is characterized by the presence of hyperactive immune cells and aberrant antibody ... See full document

... Dysregulated CD64 expression may have functional consequences, as this activating FcγR plays important roles in phagocytosis, cytolysis, and induction of inflam- matory cytokines [28]. The balance of activating (CD16, ... See full document

... immune system, represented in whole ...immune system have so far not been successful, so much that broad-based im- munosuppression still remains the mainstay in the treat- ment of both conditions ... See full document

... Late Onset Systemic Lupus Erythematosus Clinical and Immunological Characteristics ORIGINAL ARTICLE Late Onset Systemic Lupus Erythematosus Clinical and Immunological Characteristics S K J Shaikh, MMe[.] ... See full document

... Although the number of patients with renal disease is small in our study cohort, all those biopsied show a proliferative histology. Seven of these 9 had a positive LBT in the NLSE skin. Seven of them had low complement ... See full document

... of systemic lupus erythematosus (SLE) is influenced by both genetic factors and epigenetic modifications; the latter is a result of exposure to various environmental ... See full document

... Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease, which is autoimmune in origin and is characterized by the presence of autoantibodies directed against nuclear ... See full document

... factor, VCAM) which are associated with the develop- ment of CVD in SLE [32]. The increased expression of Von Willebrand factor (mediated by the production of inflammatory-cytokines) also has a pro-aggregating effect ... See full document

... for systemic lupus erythematosus (SLE) might adopt such designs if the ordinal outcome scales for SLE, such as the Systemic Lupus Activity Measure and Systemic Lupus ... See full document

...  Patients with focal lupus nephritis have segments of glomeruli involved, with other areas that are unaffected. These patients usually have urinary abnormalities including haematuria and proteinuria, but the ... See full document

... Four of 11 patients with systemic lupus erythematosus showed transiently positive direct antiglobulin Coombs tests; 1 of 5 systemic lupus erythematosus patients showed a marked rise in t[r] ... See full document

... of lupus patients displays clinical symp- toms or immunologic abnormalities that are typical for SLE, but do not fulfill the classification ...“incomplete systemic lupus erythematosus” ... See full document

... The findings from necropsies of 14 cases of systemic lupus erythematosus from this series showed that all of the children had renal involvement with either typical glom erular lesions or[r] ... See full document

... of type I interferon in systemic lupus erythematosus plasma and association with anti-RNA binding protein autoantibod- ...Serum type I interferon activity is ... See full document

... The aim of this study was to investigate whether CCR6 + memory T-helper cells and their cytokine expression was increased in SLE patients. In addition, we exam- ined whether this increase is related to the presence of ... See full document

... Spontaneous cytotoxicity mediated by natural killer (NK) cells is impaired in several human diseases including systemic lupus erythematosus (SLE). The precise mechanism(s) by which NK activity is ... See full document

... Lifestyle features are shown in Table 2. There is no significant difference regarding physical activity between the groups. This fact is important because exercise may influence oxidative stress status [29]. On the other ... See full document

... Neurological Manifestations Of Children With Systemic Lupus Erythematosus ORIGINAL ARTICLE Neurological Manifestations of Children with Systemic Lupus Erythematosus W F Loh, MRCP, I M I Hussain, FRCP,[.] ... See full document