[PDF] Top 20 The amyloid precursor protein: beyond amyloid
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The amyloid precursor protein: beyond amyloid
... In addition to stabilizing AICD and modulating nuclear signaling, the binding of APP with Fe65 has been impli- cated in regulating cell motility and growth cone dynam- ics [79,80]. In H4 neuroglioma and MDCK cells, APP ... See full document
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Influence of chlorpyrifos oxon on the development and progression of Alzheimer’s disease in amyloid precursor protein transgenic mice
... Figure 3: Treatment of amyloid precursor protein (APP) mice with chlorpyrifos oxon CPO results in exacerbated memory deficits. Memory deficits of APP mice were assessed 2 days after completion of the ... See full document
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Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
... Amyloid precursor protein (APP) is an evolutionarily conserved protein with two homologues in mammals: amyloid precursor-like protein 1 (APLP1) and amyloid ... See full document
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Role of Phosphoinositides in the biology of the amyloid precursor protein
... in amyloid precursor protein-induced proliferation of neural stem/progenitor ...Beta-amyloid precursor protein: Function in stem cell development and Alzheimer’s disease ... See full document
11
The Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: I Molecular Biology and Metabolic Processing
... The amyloid precursor protein gene (APP) and its derivative peptides have important functions in the central nervous system. APP and A fulfil criteria as neuractive peptides: presence, release and ... See full document
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Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
... the amyloid hypo the- sis of AD, which argues that accumulation and aggre- gation of amyloid-β (Aβ) peptides in the brain is causal in its ...the amyloid precursor protein (APP) by ... See full document
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Biology and pathophysiology of the amyloid precursor protein
... of amyloid b-protein (Ab), which is a 40-42 amino acid long peptide derived by proteolytic cleavages of the amyloid precursor protein (APP), with surrounding neuritic alterations and ... See full document
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Intracellular Trafficking Governs the Processing of the Amyloid Precursor Protein and the Secretion of Beta-Amyloid
... the amyloid plaques, which are the other prominent feature found in ...β- amyloid (Aβ) ...the amyloid precursor protein ...of amyloid plaques [20,21] (Figure ... See full document
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Processing of Alzheimer's amyloid precursor protein in cultured cells
... neuronal precursor cells are ...neurofilament protein, and do not express vimentin filaments (found in some neurones, glial and other cells) or glial ... See full document
257
Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
... receptor-associated protein (RAP) that has high affinity for LRP (for review see ...resident protein that serves as a molecular chaperone for members of the LDL recep- tor family to prevent premature ... See full document
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The Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: III Pharmacological Studies
... and protein dam- age [44] and oxidative stress in a cell-free system ...metal protein bind- ing substance that inhibits zinc and copper ions, has been shown to slow cognitive decline in a small sample of AD ... See full document
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Decreased levels of soluble amyloid β protein precursor and β amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus
... elevated protein levels are found in some but not all patients with CNS lupus ...β-amyloid protein (A β 42) have not been assessed at all in this condition. Protein tau is a ... See full document
8
Modeling Alzheimer's disease with non-transgenic rat models
... the amyloid precursor protein (APP) and its central role in the familial form of ...tau protein that is not encountered in AD but pertains to the frontotemporal dementia with Parkinsonism ... See full document
9
Cognitive improvement of compound danshen in an Aβ25 35 peptide induced rat model of Alzheimer’s disease
... cause of AD and is a target for AD treatment. Acetylcholin- esterase inhibitors are prescribed to AD [2]. However, these drugs have limited effects on AD [3]. Accordingly, drugs to prevent the onset of AD and its ... See full document
9
Stepping closer to treating Alzheimer’s disease patients with BACE1 inhibitor drugs
... of amyloid precursor protein (APP) at the β -secretase ...targeting amyloid deposition-mediated pathology for AD therapy has now become more ...the amyloid cascade hypothesis in AD ... See full document
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Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
... AICD: Amyloid intracellular domain; APP: Amyloid precursor protein; A β : Amyloid β ; BACE1: β -secretase; CHO: Chinese hamster ovary cell line; CHX: Cycloheximide – inhibitor of ... See full document
24
Proteomic study of sporadic inclusion body myositis
... Background: Sporadic inclusion body myositis (s-IBM) is the most commonly occurring acquired inflammatory myopathy in elderly people (>45 years); however, pathogenic mechanisms are poorly understood and diagnostic ... See full document
8
Cerebral amyloid angiopathy-related inflammation: a case report presenting with a rare variant in SORL1 gene
... Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare clinical entity, characterized by headaches, seizures, rapidly progressive cognitive decline, behavioral changes and magnetic resonance imaging ... See full document
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The role of APP in Alzheimer’s disease
... The amyloid precursor protein (APP) has been shown to play an important role in AD ...The amyloid β peptide (Aβ), which accumulates in senile plaques, a central etio- logical AD factor, is a ... See full document
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Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer’s disease mouse model
... : amyloid β peptide; AD: Alzheimer ’ s disease; APH-1: anterior pharynx- defective 1; APP: amyloid β precursor protein; BACE-1: β -site amyloid precursor protein cleaving ... See full document
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