[PDF] Top 20 The Transcriptional Transactivation Function of HBx Protein Is Important for Its Augmentation Role in Hepatitis B Virus Replication

... an important factor in ...to HBx, including transactivation of many viral and cellular genes, stimulation of various signal transduc- tion pathways, binding to a variety of protein targets, ... See full document

... unknown, HBx protein may inhibit apoptosis by blocking the transactivation of caspase cascade 3, nuclear factor kappa B (NF-κB) and phosphatidylinositol 3-kinase (PI3K) signal transduction ... See full document

... that HBx is essential for in vivo replication of the wood- chuck hepatitis virus and potentially so for replication of human HBV has stimulated interest in elucidating the primary ... See full document

... While HBx has been shown to display proapoptotic effects during replication of HBV and WHV in tissue culture (95), a possible proapoptotic effect of HBx during natural infection has not yet been ... See full document

... by HBx protein (7, 8, ...of HBx function, there is still much to learn about this viral regulatory ...conserved HBx cysteine and histidine residues (C61, C69, C137, and H139) form a ... See full document

... 3 Role of the proximal nuclear receptor binding site in transcriptional coactivator-mediated activa- tion of HBV biosynthesis in the human embryonic kidney cell line ...DNA replication intermediates ... See full document

... lower replication level from the ...encoding HBx. Together, these results demonstrate that the role for HBx in HBV replication previously described for human HepG2 cells is also evident ... See full document

... core protein dimers and/or capsids with their viral nucleic acids into the nucleus (19, 23, 34), although it is not clear whether this modification might simply favor capsid ...core protein is present in ... See full document

... an important role in HBV replication in vivo and that this effect is mediated by the function of ...of HBX with the proteasome complex in cell culture ...HBV replication resides ... See full document

... [34]). HBx promotes viral transcription by controlling histone protein methyl- transferase (PMT), DNMT activity, and recruitment of histone modifiers to maintain active ...the function of HBx ... See full document

... Hepatitis B virus (HBV) encodes the regulatory HBx protein, which is required for virus replication, although its specific role(s) in the replication ... See full document

... exert its antiprolif- erative activity (21, 61), it appeared likely that biochemical processes such as transcription, DNA replication, or RNA processing involving p53 would constitute the tumor suppres- ... See full document

... of HBx. HDM2 stabilizes HuR protein through promoting its NEDDylation level ...of HBx. We transfected 293T cells with FLAG-HBx alone or with Myc-HDM2 or Myc-HDM2-C464A and then treated ... See full document

... of hepatitis B virus encodes four overlapping open reading frames that are translated to viral core protein or HBc particle, the sur- face proteins, a reverse transcriptase (RT), and ... See full document

... DHBx affects neither viral protein expression nor viral DNA synthesis in LMH cells. In order to investigate whether DHBx affects the expression of structural proteins of DHBV, we an- alyzed the expression of the ... See full document

... lines, HBx expression in primary rat hepatocytes protected cells from mitochondrial membrane depolarization ...in HBx-expressing cells, compared to ...and HBx prevented this depolarization (6.6% ... See full document

... HBV transgenic mice, castration, and hydrodynamic injection. The HBV transgenic mouse lines Tg05, Tg31, and Tg38 were described previ- ously (15, 20). The Tg05 mouse line carries the 1.3-mer, overlength, wild- type HBV ... See full document

... pgRNA are tolerated during the synthesis of minus-strand DNA. (A) WT HBV and HBV/LacZ (HL) or HBV/DHBV (HD) chimeric variants. The white rectangles represent HBV sequences. The dotted lines represent deletions. The ... See full document

... delta virus (HDV) is a worldwide diffuse pathogen commonly associated with severe forms of liver disease (9, 21, 22, ...continuing hepatitis B virus (HBV) infection, since it requires ... See full document

... basal transcriptional apparatus effects a specific or general enhancement of gene ...basal transcriptional apparatus to those cis-acting elements via its interaction with sequence-specific cellular ... See full document