[PDF] Top 20 Whole-transcriptome sequencing identified gene expression signatures associated with aggressive clear cell renal cell carcinoma

... are associated with aggressive cancers in other organs ...also associated with OS in patients with early stage ccRCC. PLPP2 is a gene in the phosphatidic acid phosphatase (PAP) family and a ... See full document

... lymphoblastic cell lines but minimal translation in all other sets, including normal human tissues, suggesting that CT-RCC hERV-E had the capacity for translation within tumor-like tissues (Supplemental Figure ... See full document

... its gene regula- ...Ki-67 gene regulation, we performed bisulfite sequencing and methylation specific PCR (MSP) to generate the methylation profile of Ki-67 promoter in vitro and in vivo, ...cancer ... See full document

... during cell cycle suggest that Plk5 prevents cells entering S ...higher expression of Plk5 in primary tumor could be a response to the DNA damages, but Plk5 silencing by promoter hypermethylation [10–12] or ... See full document

... Renal cell carcinoma (RCC) is among the most common human cancers in the United States, with approximately 63,990 new patients and 14,400 deaths annually ...mainly clear cell ... See full document

... technology, gene expression profiles have been used to identify genes associated with progression of renal cancer ...similar expression patterns may be functionally related [10]. ... See full document

... of clear cell renal cell carcinoma (ccRCC) patients respond to immune checkpoint blockade (ICB), predictors of response remain ...abnormal expression of endogenous retroviruses ... See full document

... the identified modules in two independent HCC RNA-seq data sets indicated that modules in the training data were preserved in the testing data, especially in ...have identified a specific module (MEtan) ... See full document

... In recent years, microarray and high-throughput sequen- cing technology have been widely applied. 7,8 However, most researches focus on the screening of differentially expressed genes (DEGs), ignoring the high degree of ... See full document

... Detection of DE-miRNAs with a novel statistical method T-statistics is most widely used in differential gene ex- pression detection for microarray studies. However, there is a growing realization that the ... See full document

... factor associated with the cascade of hypoxia inducible tumour growth ...thrombi associated with angiogenic activity ...VEGF expression would be ele- vated in clear cell RCCs with VHL ... See full document

... [3–5]. Viral infection is a type of cellular stress that acti- vates p53 response that triggers apoptosis of the infected cells, leading to the suppression of viral replication [6–8]. Thus, p53 is considered as a host ... See full document

... The distinct mechanisms are crucial to explore the characters of two cancers. We found distinct mechanism in metabolism, TCA cycle, cell–cell adhesion and cell differentiation in two tumors. In ... See full document

... VEGFA gene as target that was overex- pressed in 77% of the ...opposite expression of miR-126 and VEGFA was identified ...under- expression was associated with higher histological ... See full document

... Tim-3 expression could be used as an independent prognostic factor for colon cancer ...Tim-3 expression in colon carcinoma cells may work in similar mechanisms of suppressing immune system thus ... See full document

... genes’ expression levels with OS (Table 2) and DFS (Table 3) in ...the expression levels of the four genes, and risk (four-gene signature) were all correlated with ...the expression level of ... See full document

... the expression of TR β1 mRNA, thus indicating that this post-translational activity only partially contributed to the loss of TR β1 ...β1 gene also contributed to mRNA ...β1 gene showed reduced ... See full document

... IR expression was present in 109 cases ...IR expression was significantly related to the presence of cystic change, lower Fuhrman nuclear grade, lower pathologic T stage, and lower TNM ...the ... See full document

... the Gene Commanding Height (GCH) in a particular region as a composite score accounting for gene expression stability and pooled expression coordination with expressions of other genes within ... See full document

... Despite these challenges, researchers have begun examin- ing the novel application of VEGFR TKIs in the treatment of non-clear cell RCC and have found evidence suggestive that VEGF TKIs have therapeutic ... See full document