[PDF] Top 20 NS1-Truncated Live Attenuated Virus Vaccine Provides Robust Protection to Aged Mice from Viral Challenge
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NS1-Truncated Live Attenuated Virus Vaccine Provides Robust Protection to Aged Mice from Viral Challenge
... the vaccine virus sup- pressed viral replication in the lungs, mice were vaccinated and challenged as described above, but were sacrificed on day 4 postin- ...in viral titers was seen ... See full document
9
Influenza B Virus NS1-Truncated Mutants: Live-Attenuated Vaccine Approach
... B virus vaccine ...in mice (3) or directly altered in its M1 gene ...the viral genetic background so that the virus is no longer authentic and has become instead a laboratory ...⫺/⫺ ... See full document
11
A Live Attenuated H7N7 Candidate Vaccine Virus Induces Neutralizing Antibody That Confers Protection from Challenge in Mice, Ferrets, and Monkeys
... the vaccine completely protected mice from pulmonary replication of homologous and heterologous vi- ruses from the North American and Eurasian lineages and prevented the dissemination of the ... See full document
11
A Live Attenuated Human Metapneumovirus Vaccine Strain Provides Complete Protection against Homologous Viral Infection and Cross-Protection against Heterologous Viral Infection in BALB/c Mice
... three viral transmembrane surface proteins: a small hydrophobic (SH) glycoprotein with unknown function, the G protein (a putative major attachment protein), and the fusion (F) protein, which mediates viral ... See full document
9
A Live Attenuated Equine Infectious Anemia Virus Proviral Vaccine with a Modified S2 Gene Provides Protection from Detectable Infection by Intravenous Virulent Virus Challenge of Experimentally Inoculated Horses
... AIDS vaccine is the production of en- during host immune responses that are able to protect against infection through natural routes of exposure by diverse strains of ...early vaccine devel- opment in human ... See full document
10
A Reassortment-Incompetent Live Attenuated Influenza Virus Vaccine for Protection against Pandemic Virus Strains
... BALB/c mice were immunized with different doses of rIBV- NS110-VN04HA, rWT B virus, or ...post- challenge, three mice per group were euthanized, and their lungs were harvested for the analysis ... See full document
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Live Attenuated Influenza Vaccine Provides Superior Protection from Heterologous Infection in Pigs with Maternal Antibodies without Inducing Vaccine-Associated Enhanced Respiratory Disease
... significant protection in the absence of MDA against the replication of not only the homologous TX98 strain but also the heterologous CO99 ...a robust IgA response in the lower respiratory tract when the ... See full document
9
A Combination DNA and Attenuated Simian Immunodeficiency Virus Vaccine Strategy Provides Enhanced Protection from Simian/Human Immunodeficiency Virus-Induced Disease
... with live attenuated SIVmac239 ⌬nef, issues remain concerning the safety, immunogenicity, and overall protective ...a live attenuated virus immunization and was also shown to positively ... See full document
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Development of a High-Yield Live Attenuated H7N9 Influenza Virus Vaccine That Provides Protection against Homologous and Heterologous H7 Wild-Type Viruses in Ferrets
... influenza virus infection in humans, we developed a live attenuated H7N9 influenza vac- cine (LAIV) with two amino acid substitutions in the viral HA protein that improved vaccine yield ... See full document
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Development of a Mouse-Adapted Live Attenuated Influenza Virus That Permits In Vivo Analysis of Enhancements to the Safety of Live Attenuated Influenza Virus Vaccine
... influenza virus vaccines are reformulated each year due to the changing antigenicity of the virus, where virus-neutral- izing humoral immunity typically only confers protection against matched ... See full document
6
Live, Attenuated Simian Immunodeficiency Virus SIVmac-M4, with Point Mutations in the Env Transmembrane Protein Intracytoplasmic Domain, Provides Partial Protection from Mucosal Challenge with Pathogenic SIVmac251
... 2002 Attenuated molecular clones of simian immunodeficiency virus (SIVmac) are important tools for studying the correlates of protective immunity to lentivirus infection in nonhuman ...highly ... See full document
14
Characterization of a Live-Attenuated Retroviral Vaccine Demonstrates Protection via Immune Mechanisms
... 1998 Live-attenuated retroviruses have been shown to be effective retroviral vaccines, but currently little is known regarding the mechanisms of ...Friend virus as a model to analyze characteristics ... See full document
5
Impact of Type I Interferon on the Safety and Immunogenicity of an Experimental Live-Attenuated Herpes Simplex Virus 1 Vaccine in Mice
... of viral genetics, total viral burden, and host immune ...heterologous protection associated with other latent herpesvirus infections ...⫺/⫺ mice following infection with HSV-1 0ΔNLS was an ... See full document
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A Live, Attenuated Bordetella pertussis Vaccine Provides Long-Term Protection against Virulent Challenge in a Murine Model
... immunity from birth. Recently, a live, attenuated whooping cough vaccine, BPZE1, has been ...of protection against virulent bacterial challenge comparable to that conferred by ... See full document
7
Protection by Live, Attenuated Simian Immunodeficiency Virus against Heterologous Challenge
... a live, attenuated deletion mutant of simian immunodeficiency virus (SIV), SIVmac239 ⌬ 3, which is missing nef and vpr genes, to protect against challenge by heterologous strains ... See full document
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Evidence for Recombination of Live, Attenuated Immunodeficiency Virus Vaccine with Challenge Virus to a More Virulent Strain
... protected from pro- ductive SIVmac239 infection, although SIVmac239 challenge virus sequences had been detected at one time point by nested PCR (11), the question of why the potential recombinant ... See full document
6
Vaccination of Pigs against Swine Influenza Viruses by Using an NS1-Truncated Modified Live-Virus Vaccine
... modified live TX98 NS1Œ126 virus followed by H1N1 or H3N2 SIV challenge induced no or a very low level of antibodies to NS1 protein by use of our NS1 ...this vaccine and the ... See full document
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Influence of Mismatch of Env Sequences on Vaccine Protection by Live Attenuated Simian Immunodeficiency Virus
... Generation of viral stocks. HEK293T/17 cells were subcultured seven times before transfection. For the preparation of viral stocks, 25 T75 flasks containing 1.5E6 cells each were prepared. The medium was ... See full document
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Cross-Protection against Marburg Virus Strains by Using a Live, Attenuated Recombinant Vaccine
... MARVGP-Musoke showed any evidence of clinical illness ei- ther after vaccination or after the MARV challenge. Impor- tantly, all of the animals vaccinated with VSV ⌬G/MARVGP- Musoke survived against a heterologous ... See full document
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Live Attenuated Influenza Virus Vaccine Trial in Children
... The one child with a low antibody titer, who did not respond to the vaccine, was given a second identical dose six weeks later, and devel- oped a rise from < 4 to 512.. The geometric [r] ... See full document
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