[PDF] Top 20 Unusual Features of Sodium Taurocholate Cotransporting Polypeptide as a Hepatitis B Virus Receptor
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Unusual Features of Sodium Taurocholate Cotransporting Polypeptide as a Hepatitis B Virus Receptor
... cytomegalo- virus (CMV) ...of virus purification, the inoculation size and pro- cedure, and the culture conditions on HBV infectivity were deter- ... See full document
12
Molecular Determinants of Hepatitis B and D Virus Entry Restriction in Mouse Sodium Taurocholate Cotransporting Polypeptide
... a receptor complex for efficient infection (34, ...NTCP receptor binding (11, 12), and the antigenic loop of the S domain, which has been demonstrated to mediate initial attachment of the virus to ... See full document
15
Sodium Taurocholate Cotransporting Polypeptide Mediates Woolly Monkey Hepatitis B Virus Infection of Tupaia Hepatocytes
... same receptor engagement of WMHBV and HBV are of great importance to consolidate the use of WMHBV as a surrogate for ...a receptor will shed light on the likelihood of NTCP’s orthologs serving as a common ... See full document
9
N-Linked Glycosylation Is Not Essential for Sodium Taurocholate Cotransporting Polypeptide To Mediate Hepatitis B Virus Infection In Vitro
... support cHBV infection and were severely impaired in bile acid transport. In Western blotting, both single mutants showed higher NTCP protein levels than the wild-type construct, whereas the double mutant had extremely ... See full document
13
Hepatitis B Virus Infection of a Mouse Hepatic Cell Line Reconstituted with Human Sodium Taurocholate Cotransporting Polypeptide
... We describe for the first time a mouse liver cell line that, solely upon expression of the hNTCP receptor, becomes susceptible to HBV. In contrast to other murine cell lines (5), AML12 hNTCP cells support HBV ... See full document
5
Development of a cell-based assay to identify hepatitis B virus entry inhibitors targeting the sodium taurocholate cotransporting polypeptide
... Sodium taurocholate cotransporting polypeptide (NTCP) is a major entry receptor of hepatitis B virus (HBV) and one of the most attractive targets for anti-HBV ...of ... See full document
14
A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide
... Natural products, possessing a wide range of structural and bioactive diversity with drug-like structures, have served as a rich source of drugs for treatment of a variety of diseases (15, 16): 34% of drugs approved in ... See full document
9
Modification of Three Amino Acids in Sodium Taurocholate Cotransporting Polypeptide Renders Mice Susceptible to Infection with Hepatitis D Virus In Vivo
... the receptor, or the small region covering aa 84 to 87 may exhibit more limited accessibility to 18D1 than the pre-S1 do- main, especially if prior interaction of the virions with the attach- ment factor heparan ... See full document
9
A Single Adaptive Mutation in Sodium Taurocholate Cotransporting Polypeptide Induced by Hepadnaviruses Determines Virus Species Specificity
... ABSTRACT Hepatitis B virus (HBV) and its hepadnavirus relatives infect a wide range of vertebrates, from fish to ...the sodium taurocholate cotransporting polypeptide ... See full document
17
Viral Entry of Hepatitis B and D Viruses and Bile Salts Transportation Share Common Molecular Determinants on Sodium Taurocholate Cotransporting Polypeptide
... In this study, we examined NTCP-mediated HBV and HDV viral infections in relation to the receptor’s physiological role of transporting bile acids. We found that the HBV pre-S1 domain efficiently blocked bile salts ... See full document
12
Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles
... by hepatitis B virus (HBV) is the major contributor to liver disease ...Myrcludex B, but not with 10 M tenofovir, 100 U of interferon alpha, or a 1 M concentration of the capsid assembly ... See full document
22
The Role of the Sodium-Taurocholate Cotransporting Polypeptide (NTCP) and of the Bile Salt Export Pump (BSEP) in Physiology and Pathophysiology of Bile Formation
... the sodium taurocholate cotransporting polypeptide (Ntcp in rodents, NTCP in humans, gene symbol Slc10a1 in rodents, SLC10A1 in humans) and to a minor extent in a sodium-independent ... See full document
82
Upregulation of sodium taurocholate cotransporter polypeptide during hepatogenic differentiation of umbilical cord matrix mesenchymal stem cells facilitates hepatitis B entry
... UCMSCs are easily and reproducibly isolated from a regularly available source and maintain their features even after cryopreservation. Upon in vitro hepatogenic differen- tiation, D-UCMSCs express NTCP and enhance ... See full document
11
Age-dependent glycosylation of the sodium taurocholate cotransporter polypeptide: From fetal to adult human livers
... Abstract: Sodium taurocholate cotransporter polypeptide (NTCP), mainly expressed on the sinusoidal membrane of hepatocytes, is one of the major transporters responsible for liver bile acid (BA) ... See full document
12
Carboxypeptidase D Is an Avian Hepatitis B Virus Receptor
... Nucleotide sequence accession number. The GenBank accession number of the sequence reported is AF039749. RESULTS Design of reconstitution experiments. We anticipated that the ability of DCPD to mediate DHBV binding in ... See full document
7
Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice.
... Lanes: CHO, 50 ng of CHO-derived HBsAg particles; Serum, 50 ng transgenic mouse serum HBsAg particles; pMT-PSX and pAlb-PSX, 120, 46, and 2.5 ,ug of liver protein from an MT-PSX mouse be[r] ... See full document
8
Epidemiological features of hepatitis B virus infection in Malaysians
... In order to plan a strategy for control of hepatitis B virus infection in Malaysia, we determined (i) the annual rate of infection, (ii) the basic reproductive rate, Ro, of this infectio[r] ... See full document
6
Hepatitis B virus polypeptide X: expression in Escherichia coli and identification of specific antibodies in sera from hepatitis B virus-infected humans.
... Localization on the viral genome and nucle- otide sequence of the gene coding for the two major polypeptides of the hepatitis B surface antigen (HBsAg). Nu- cleic Acids Res[r] ... See full document
9
Characterization of Unusual Escape Variants of Hepatitis B Virus Isolated from a Hepatitis B Surface Antigen-Negative Subject
... 1998 Hepatitis B virus DNA was extracted from serial serum samples of a hepatitis B surface antigen-negative patient with antibodies to the core protein as the only marker of an ... See full document
5
HEPATITIS B VIRUS II. HEPATITIS B VIRUS RECOMMENDATIONS:
... Several case reports have described a flare of hepatitis following initiation of HAART with subse- quent clearance of HBsAg, which is postulated to reflect improved immune function. The frequency of this ... See full document
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