[PDF] Top 20 Use of randomisation in clinical trials: a survey of UK practice
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Use of randomisation in clinical trials: a survey of UK practice
... a randomisation scheme using minimisation with stratifi- cation by centre or clinician, although International Conference on Harmonisation (ICH) guidelines still rec- ommend this ... See full document
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Placebo-controlled clinical trials: how trial documents justify the use of randomisation and placebo
... placebo-controlled clinical drug ...A clinical trial was defined as a prospective study with human subjects that is intended to assess the efficacy, safety, or pharmacokinetics (absorption, distribution, ... See full document
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Use of structured musculoskeletal examination routines in undergraduate medical education and postgraduate clinical practice – a UK survey
... MSK clinical skills at UK medical schools, with evidence of uptake and use in postgraduate clinical ...upon clinical per- formance, and this would require a different methodo- logical ... See full document
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A review of current practice in the design and assessment of internal pilots in UK NIHR clinical trials
... 89 trials which had closed by May 2016, 20 (30%) were judged ‘ not feasible ’ , of which 6 (7%) were intending to apply for funding for the main trial ...the trials underwent further reviews, none specified ... See full document
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The effect of tranexamic acid on the risk of death and hysterectomy in women with post partum haemorrhage: statistical analysis plan for the WOMAN trial
... Reporting Trials; CRASH-2 trial: Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage Trial; CTU: clinical trials unit; DIC: disseminated intravascular coagulation; ... See full document
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What are the main inefficiencies in trial conduct : a survey of UKCRC registered clinical trials units in the UK
... our survey represented a wide range of roles and CTUs, although the response rate was lower than expected (owing to a problem with the email distribution list, subsequently corrected but not in time for our ... See full document
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What are the main inefficiencies in trial conduct: a survey of UKCRC registered clinical trials units in the UK
... our survey represented a wide range of roles and CTUs, although the response rate was lower than expected (owing to a problem with the email distribution list, subsequently corrected but not in time for our ... See full document
7
Trial Steering Committees in randomised controlled trials: A survey of registered clinical trials units to establish current practice and experiences
... There is great variation in the use of voting rights for non-independent members. Only 15% of units follow the Health Technology Assessment guidelines of 75% independent representation [5]. The consequence of this ... See full document
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An evaluation of risk based monitoring in pragmatic trials in UK Clinical Trials Units
... In 2016, the integrated addendum to ICH-GCP was published, building on the guidance jointly published by the Medicines and Healthcare products Regulatory Agency (MHRA), the Department of Health, and the Medical Research ... See full document
7
A re-randomisation design for clinical trials
... routine clinical practice, then the treatment effect from the first time it is given may be a misleading representation of what will occur for the majority of times it is ...across randomisation ... See full document
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Hypoglycemia: a review of definitions used in clinical trials evaluating antihyperglycemic drugs for diabetes
... the trials that used a cutoff value of ...Among trials with intermediate-long-acting insulins (neutral protamine Hagedorn insulin, detemir, glargine), 7 of 26 trials (27%) used a cutoff of ... See full document
6
The concept of control of COPD in clinical practice
... the clinical characteristics of the patients, the level of severity, and the response to the different ...the Clinical COPD ...the use of rescue medication, the level of physical activity, and sputum ... See full document
9
A survey of nurses' and podiatrists' attitudes, skills and knowledge of lower extremity wound care
... However, disparities were identified between less experienced nurses and those with more experience in terms of years and qualifications. Less experienced nurses were more satisfied with the level of wound care in their ... See full document
6
A profile of osteopathic practice in Australia 2010–2011: a cross sectional survey
... paper-based survey using a modified UK-developed standardised data collection tool was distributed to and completed by osteopaths across Australia between June 2010 and June ... See full document
10
Reported use of evidence in clinical practice: a survey of rehabilitation practices in Norway
... fidelity. Survey respondents indicated there may be variation in delivery of EBPs within each clinic and throughout the region, which indicates an opportunity to improve use of EBPs or the fidelity in which ... See full document
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A meta-analysis of clinical trials assessing the effect of radiofrequency ablation for breast cancer
... Methods: A literature search was conducted in PubMed, Embase, and Web of Science data- bases. Eligible studies were clinical trials that assessed RFA in patients with breast cancer. The outcomes included ... See full document
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New regulation for clinical stem cell research in China : expected impact and challenges for implementation
... all, clinical investigators may not charge money for patients taking part in clinical studies, and hospitals are not allowed to advertise stem cell trials as ... See full document
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Breast clinicians: their contribution to the breast screening programme in England and implications of the current age structure
... Methods: Retrospective review of 157 breast MRIs in our local unit from January 2010 to May 2012 was carried out. Of these, 35 women had biopsy- proven invasive lobular cancer. Dotarem-enhanced 1.5T MRI was performed and ... See full document
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Pain relief in labor: a survey of awareness, attitude, and practice of health care providers in Zaria, Nigeria
... and practice of the same, with many providers having no genuine reason(s) for not offering pain relief to their clients during ...their practice to their attitudes, and need to be helped to do this through ... See full document
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Applying results from clinical trials: tranexamic acid in trauma patients
... large UK-based trauma registry, we showed that if TXA use is limited to patients with a baseline risk of more than 20%, we would miss most of the benefit, since 53% of TXA preventable deaths are in patients ... See full document
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