[PDF] Top 20 Uses of cardiomyocytes generated from induced pluripotent stem cells

Uses of cardiomyocytes generated from induced pluripotent stem cells

... beating cardiomyocytes have been detected from ES cells cultured in the absence of factors supporting ...erentiation from ES cells by recapitu- lating the early events of heart ... See full document

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Neuroinflammatory astrocytes generated from cord blood-derived human induced pluripotent stem cells

... are induced by reactive microglia, and screening identifies the candidate microglia proteins TNFα, IL-1α, and C1q as the strongest inducers of a partial A1 astrocyte phenotype ... See full document

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Generation of induced pluripotent stem cells from renal tubular cells of a patient with Alport syndrome

... we generated induced pluripotent stem cells (iPSCs) from renal tubular cells of a patient with ...Sertoli cells and the accompanying epigenetic changes at each ... See full document

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In vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations

... derived from a lissencephaly patient can migrate normally has not been ...progenitor cells or the delay in polarization before neuronal ...already generated a miniature brain from iPSCs ... See full document

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Transplantation of induced pluripotent stem cell-derived mesenchymal stem cells improved erectile dysfunction induced by cavernous nerve injury

... Induced pluripotent stem cells (iPSC) are pluripotent stem cells generated by reprogramming somatic cells ...(induced pluripotent stem ... See full document

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Exosomes Secreted from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Osteonecrosis of the Femoral Head by Promoting Angiogenesis

... we induced iPSCs into MSCs for the generation of ...derived from iPS-MSCs did not induce immune reactions in vivo ...derived from iPSCs could generate even greater regenerative potential, which is ... See full document

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Signature of circular RNAs in human induced pluripotent stem cells and derived cardiomyocytes

... are generated by back-splicing of exons of parental transcripts, we performed correlation analysis based on our RNA-sequencing ...differentiated cardiomyocytes, including TNNT2, MYL2, MYH6, and MYH7, were ... See full document

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Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells: An In Vitro Model to Predict Cardiac Effects of Drugs

... Introduction: Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CM) form spontaneously beating syncytia in-vitro ...2 from β 1 agonists, as well as ... See full document

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Therapeutic discovery for marrow failure with MDS predisposition using pluripotent stem cells

... we generated induced pluripotent stem cells (iPSCs) derived from patients with Shwachman-Diamond syndrome (SDS), a bone marrow failure disorder with MDS predisposition, and ... See full document

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Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington’s disease patient cells

... detached from MEF by incubation with collagenase ...progenitor cells were mechanically disso- ciated by trituration to a single cell suspension and plated on poly-L-ornithine (Sigma, 20 μg/ml) and laminin ... See full document

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Cardiomyocytes from human pluripotent stem cells: from laboratory curiosity to industrial biomedical platform

... increases from 12kPa in the embryonic heart to 39kPa in the neonate ...translate from in vivo to in ...CMs from chicken em- bryos produced contractile force and developed actomyosin striations ... See full document

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Selection of human induced pluripotent stem cells lines optimization of cardiomyocytes differentiation in an integrated suspension microcarrier bioreactor

... 55]. In our studies, a high throughput platform (Optio- QUANT™) developed by Ternion Bioscience, Singapore, was used to image and quantify subtle changes of mem- brane potentials in hPSC-/hiPSC-derived CMs, based on ... See full document

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Generation of human induced pluripotent stem cell-derived cardiomyocytes in 2D monolayer and scalable 3D suspension bioreactor cultures with reduced batch-to-batch variations

... show cells in each group stained with isotype (grey histogram) or TNNT2-specific (red histogram) ...TNNT2-positive cells (individual, representative measurements), and right panel bar chart shows ... See full document

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Generation of induced pluripotent stem cells from large domestic animals

... also generated murine and human iPSC cells, aiming to define a reproducible and controlled pluripo- tency induction protocol for domestic ...iPS cells derived herein were positive for NANOG by im- ... See full document

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PubMedCentral-PMC5659840.pdf

... CM-like cells for replacement therapies offers alternative strategies for repairing damaged ...of induced pluripotent stem cells (iPSC) (Takahashi and Yamanaka, 2006; Zhang et ... See full document

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Cardiotoxicity evaluation using human embryonic stem cells and induced pluripotent stem cell-derived cardiomyocytes

... The discovery of hPSC-CMs, including hPSC-CMs and hESC-CMs, has been an attractive in vitro model to study cardiotoxicity. Many researchers have used hiPSC- CMs and hESC-CMs as screening models for pro- arrhythmic ... See full document

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Disruption of histamine/H1R signaling pathway represses cardiac differentiation and maturation of human induced pluripotent stem cells

... into cardiomyocytes according to a classical protocol ...mesoderm cells. Usually, spontaneously beating cardiomyocytes initially appeared on days 8–10 (GiWi; ...days from the initiation of ... See full document

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Engineered Microenvironments for Maturation of Stem Cell Derived Cardiac Myocytes

... forces generated by tissues themselves ...on cardiomyocytes, adult stem cells, and human pluripotent ...exposed cells to cyclic stretch over a period of 24-72 h at 10-20% ... See full document

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DeepNEU: cellular reprogramming comes of age – a machine learning platform with application to rare diseases research

... Artificially-induced cardiomyocytes; aiNSCs: Artificially-induced neural stem cells; aiPSC: Artificially-induced pluripotent stem cells; ALP: Alkaline ... See full document

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iPSC derived β cells model diabetes due to glucokinase deficiency

... whether stem cell–derived β cells recapitulate molecular-physiological phenotypes of a diabetic subject, we generated induced pluripotent stem cells (iPSCs) from ... See full document

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