[PDF] Top 20 The Varicella-Zoster Virus Open Reading Frame 63 Latency-Associated Protein Is Critical for Establishment of Latency
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The Varicella-Zoster Virus Open Reading Frame 63 Latency-Associated Protein Is Critical for Establishment of Latency
... VZV latency. The virus must enter the nerve end- ing, be transported up the axon, enter the ganglia, persist in the ganglia during acute infection, and establish a latent ...with virus in which the ... See full document
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Regions of the Varicella-Zoster Virus Open Reading Frame 63 Latency-Associated Protein Important for Replication In Vitro Are Also Critical for Efficient Establishment of Latency
... of frame as previously described (5). Plasmid 63-BclI, which contains ORF63 (VZV nucleotides 106592 to 112215) within a VZV BclI fragment, was also previously described ...plasmid 63-BclI was ... See full document
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Absence or Overexpression of the Varicella-Zoster Virus (VZV) ORF29 Latency-Associated Protein Impairs Late Gene Expression and Reduces VZV Latency in a Rodent Model
... during latency in human sensory or cranial nerve ...of latency (36, 39), while ORFs 4 and 63 (6, 7) have a critical role in latency in ...efficient establishment of ... See full document
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Varicella-Zoster Virus IE63, a Major Viral Latency Protein, Is Required To Inhibit the Alpha Interferon-Induced Antiviral Response
... is critical for defense against invading viruses. In response to virus infection, a number of signal transduction pathways are activated, including activation of genes that encode type I interferons (IFNs), ... See full document
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Varicella-Zoster Virus ORF4 Latency-Associated Protein Is Important for Establishment of Latency
... Varicella-zoster virus (VZV) encodes at least six genes that are expressed during ...immediate-early protein that is present in the virion tegument. ORF4 RNA and protein have been ... See full document
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Proteins and cis-acting elements associated with transactivation of the varicella-zoster virus (VZV) immediate-early gene 62 promoter by VZV open reading frame 10 protein.
... Varicella-zoster virus (VZV) is a member of the alphaher- pesvirus ...simplex virus type 1 (HSV-1), another member of the alphaherpesvirus subfamily, is induced by the virion-associated ... See full document
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Simian Varicella Virus Expresses a Latency-Associated Transcript That Is Antisense to Open Reading Frame 61 (ICP0) mRNA in Neural Ganglia of Latently Infected Monkeys
... Simian varicella virus (SVV) and varicella-zoster virus (VZV) are closely related alphaherpesviruses that cause varicella (chickenpox) in nonhuman primates and humans, ...to ... See full document
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Mutational Analysis of the Repeated Open Reading Frames, ORFs 63 and 70 and ORFs 64 and 69, of Varicella-Zoster Virus
... Varicella-zoster virus (VZV) open reading frame 63 (ORF63), located between nucleotides 110581 and 111417 in the internal repeat region, encodes a nuclear phosphoprotein ... See full document
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Virion Association of IE62, the Varicella-Zoster Virus (VZV) Major Transcriptional Regulatory Protein, Requires Expression of the VZV Open Reading Frame 66 Protein Kinase
... tegument protein? Two models for tegument assembly have been proposed which are not necessarily mutu- ally ...ment protein preferentially accumulates at the trans-Golgi net- work in infected cells ... See full document
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Targeted Genome Sequencing Reveals Varicella-Zoster Virus Open Reading Frame 12 Deletion
... and 63 as well as the inverse ORFs 70 and 71 at passage 5 expanded to five copies by passage 22 and was maintained at passage 72; and (iii) one copy of an 18-bp duplication in ORF 22 at passage 5 was deleted by ... See full document
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Dissection of a Novel Nuclear Localization Signal in Open Reading Frame 29 of Varicella-Zoster Virus
... Open reading frame 29 (ORF29) of varicella-zoster virus (VZV) encodes a 120-kDa single-stranded DNA binding protein (ORF29p) that is not packaged in the virion and is ... See full document
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Epigenetic Regulation of Varicella-Zoster Virus Open Reading Frames 62 and 63 in Latently Infected Human Trigeminal Ganglia
... VZV open reading frames (ORFs 21, 29, 62, 63, and 66) in latently infected human gan- glia (4, ...during latency is ...that virus gene reg- ulation is associated with ... See full document
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Phosphorylation and nuclear localization of the varicella-zoster virus gene 63 protein.
... Varicella-zoster virus (VZV) is a member of the Alphaher- pesvirinae subfamily of the Herpesviridae family and is the in- fectious agent of chicken pox following primary infection and of shingles on ... See full document
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The transcriptional regulatory proteins encoded by varicella-zoster virus open reading frames (ORFs) 4 and 63, but not ORF 61, are associated with purified virus particles.
... and 63 have been described previously ...ORF protein fusions to the maltose binding protein (MBP) by using the pMALC Fusion Protein Expression System (New England Biolabs ...fusion ... See full document
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Varicella-zoster virus (VZV) open reading frame 61 protein transactivates VZV gene promoters and enhances the infectivity of VZV DNA.
... In addition, the plaquing efficiency of HSV-1 in1814 in cells transfected with HSV-1 ICPO is increased up to 10-fold 1, indicating that ICPO plays a critical role in viral gene expressio[r] ... See full document
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Varicella-Zoster Virus Open Reading Frame 10 Is a Virulence Determinant in Skin Cells but Not in T Cells In Vivo
... ORF10 protein did not alter VZV infection in skin xenografts, the complete deletion of ORF10 was associated with substan- tially impaired replication and cell-cell spread of VZV in ...total virus ... See full document
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Varicella-Zoster Virus Open Reading Frame 21, Which Is Expressed during Latency, Is Essential for Virus Replication but Dispensable for Establishment of Latency
... Cells and viruses. Human melanoma (MeWo) cells were used for virus prop- agation and transfection. Recombinant VZV was derived by using cosmids from the attenuated Oka strain of VZV. A MeWo cell line expressing ... See full document
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Nuclear Accumulation of IE62, the Varicella-Zoster Virus (VZV) Major Transcriptional Regulatory Protein, Is Inhibited by Phosphorylation Mediated by the VZV Open Reading Frame 66 Protein Kinase
... VZV protein kinases phos- phorylate the major regulatory protein of ...are associated with different cellular compartments, but the identity of the protein kinases involved remains un- known ... See full document
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Deletion in Open Reading Frame 49 of Varicella-Zoster Virus Reduces Virus Growth in Human Malignant Melanoma Cells but Not in Human Embryonic Fibroblasts
... the varicella-zoster virus (VZV) is likely a myristylated tegument protein, and its homologs are conserved across the herpesvirus ...simplex virus type 1 and of pseudorabies ... See full document
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Varicella-Zoster Virus Open Reading Frame 66 Protein Kinase Is Required for Efficient Viral Growth in Primary Human Corneal Stromal Fibroblast Cells
... Analysis of viral growth. VZV for growth rate studies was prepared from aliquoted and titrated stocks of virus in MeWo cells stored in liquid nitrogen. Stocks were 80 to 95% infected at the time of preparation, to ... See full document
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