[PDF] Top 20 Vitamin D supplementation in the management of knee osteoarthritis: study protocol for a randomized controlled trial

... total knee replacement [45,50,51], suggesting they are clinically ...in knee pain over time using WOMAC as a co-primary ...this study will show whether vitamin D supplementation ... See full document

... we will conduct sensitivity analysis described below wherein missing data are imputed to increasingly adverse degrees to explore whether the primary result still stands. As a supportive analysis, efficacy will also be ... See full document

... This group will receive a book [76] published by PLE 2- NO’ s scientific team. This book contains descriptions and tips for managing KOA in addition to educational and ex- ercise information presented as images. ... See full document

... Background: Osteoarthritis (OA) is the most prevalent chronic joint disease, characterized by joint structural deterioration, pain and loss of function among the ...enhanced management via ...enhance ... See full document

... multicenter randomized, double-blind, placebo- controlled ...Clinical Trial Ethics Committee of Huazhong University of Science and Technology ...Clinical Trial Ethics Committee of The First ... See full document

... The management of KOA is broadly di- vided into nonpharmacological, pharmacological, and surgical treatments ...optimal management of pa- tients with KOA requires a combination of pharmaco- logical and ... See full document

... Knee osteoarthritis (KOA) is a major cause of disability in the aging population and a burden on healthcare resources ...Pathologically, osteoarthritis (OA) is characterized by progressive loss of ... See full document

... cient vitamin D level in month 24 (62 % partici- pants > 50 nmol/l) in the VIDEO study, which may have masked the effect of vitamin D supplementation on inflammatory and ... See full document

... in vitamin C and emblicanins A and B ...Their study included 19 randomized and 14 non-randomized controlled trials on 12 different drugs and three non-pharmaceutical inter- ... See full document

... and randomized to either verum acupuncture, sham acupuncture or waiting-list groups with 36 patients in each ...This study will focus on detecting the cerebral functional connectivity changes elicited by ... See full document

... Background: Osteoarthritis is a relatively common musculoskeletal disorder that increases in prevalence with ...Worldwide, knee osteoarthritis is one of the leading causes of disability, particularly ... See full document

... the knee; (iii) have suspected tears in any ligaments or menisci or acute inflammation of the synovial capsule; (iv) have a history of trauma, ligament damage, fracture, or surgery on the knee(s) within 6 ... See full document

... the study design in- clude the evaluation of socio-demographic, co-morbidities, concomitant medication use and quality of life factors; all factors known to influence adherence to vitamin supple- ...to ... See full document

... Vitamin D has well established endocrine functions in calcium absorption and healthy mineralization of bone as well as muscle function ...Low vitamin D levels have also been associated with ... See full document

... the study. The protocol was approved by the Institu- tional Helsinki Committee Registry of Assaf Harofeh Medical Center in May 2005 (Helsinki Registration Num- ber ...The study is registered in the ... See full document

... multicenter, randomized, open, assessor-blinded, parallel-group clinical ...McMaster osteoarthritis index (K-WOMAC), patient global assessment (PGA), and the European quality of life five dimension five ... See full document

... participation. Participation in the study is completely voluntary. Patients will be able to withdraw at any time. The decision to participate or withdraw will not affect their existing treatment or service ... See full document

... The protocol meets the legal requirements involving research in humans, according to the Declaration of ...This protocol was ap- proved by the Ethics Committee of the Health Sciences Institute of the ... See full document

... the study will be referred by care providers to a member of the research team who will de- scribe the informed consent ...the study will be explained to patients, including its main aims, procedures, ... See full document

... with knee osteoarthritis (OA). Knee OA, a common chronic health condition, affects the daily lives of millions of people worldwide by causing knee pain and difficulty performing day-to-day ... See full document