[PDF] Top 20 The XPC-hHR23b complex and nucleotide excision repair of DNA
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The XPC-hHR23b complex and nucleotide excision repair of DNA
... contained XPC (pl25) cDNA in the Invitrogen baculovirus expression vector, ...both XPC (pl25) and hHR23B (p58) cD N A 's in a Clontech baculovirus expression vector, ... See full document
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Mechanism and regulation of DNA damage recognition in nucleotide excision repair
... Nucleotide excision repair (NER) is a versatile DNA repair pathway, which can remove an extremely broad range of base lesions from the ...the XPC protein complex initiates ... See full document
6
The helicase XPD unwinds bubble structures and is not stalled by DNA lesions removed by the nucleotide excision repair pathway
... of DNA helicases with iron–sulphur cluster ...in DNA unwinding during nucleotide excision repair ...a DNA bubble structure, differentiating it from the related helicases FancJ ... See full document
11
Enhanced nucleotide excision repair capacity in lung cancer cells by preconditioning with DNA-damaging agents
... for nucleotide excision repair (NER) is a major determinant of the efficacy of and resistance to DNA-damaging chemotherapeutics, such as ...with DNA-damaging ...cisplatin repair ... See full document
12
Nucleotide excision repair and recombination are engaged in repair of trans-4-hydroxy-2-nonenal adducts to DNA bases in Escherichia coli
... NER repair. (iii) The most fre- quent type of mutations in HNE-treated DNA of phages grown in wild-type bacteria were G:C → A:T transitions, whereas in DNA of phages grown in recA- defective ... See full document
10
Nucleotide excision repair deficiency in melanoma in response to UVA
... (XP) DNA damage accumulates rapidly after UV-light exposure that is associated with the development of many skin cancers on sunlight exposed areas of ...genes, XPC and DDB2 (XPE) in patients with XP, but ... See full document
11
Defective DNA repair and chromatin organization in patients with quiescent systemic lupus erythematosus
... the nucleotide excision repair was measured in six patients with quiescent disease and their matched ...of nucleotide excision repair at the N- ras locus strongly correlates with ... See full document
12
Interactions and function of nucleotide excision repair complexes
... e excision repairosom ...of DNA and w ithout intentional DNA dam age to the ...e complex alone (w ithout com plem enting extract) was not active in NER ...Y-shaped DNA substrates in the ... See full document
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The Nucleotide Excision Repair Pathway Limits L1 Retrotransposition
... The extremely large TSDs found in NER-deficient L1 in- sertions fall within the size range of genomic copy number variations (Eichler 2001). This large size makes them poten- tially more deleterious as insertions. ... See full document
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Genetic variants in the nucleotide excision repair pathway genes and gastric cancer susceptibility in a southern Chinese population
... controls, and the other included 126 cases and 144 controls. No significant association was detected in these two studies. However, all the included polymorphisms of ERCC1 in these two studies were not under ... See full document
10
Global Genome Nucleotide Excision Repair Proteins Rhp7p and Rhp41p Are Involved in Abasic Site Repair of Schizosaccharomyces pombe
... Nucleotide excision repair (NER) is a versatile DNA repair pathway that removes a broad spectrum of DNA lesions that tend to distort the double helix, and is well known for its ... See full document
10
Advances in using PARP inhibitors to treat cancer
... in DNA damage that is repaired by a variety of mechan- isms, including base excision repair (BER), mismatch repair (MMR), nucleotide excision repair (NER), single strand ... See full document
5
Repair of UVB-induced DNA damage is reduced in melanoma due to low XPC and global genome repair
... to DNA damage, which when unrepaired induces C>T ...genome repair (GGR) branch of nucleotide excision repair (NER) is responsible for repairing UV-induced DNA damage across ... See full document
14
<em>ERCC1 </em>and <em>XRCC1 </em>as biomarkers for lung and head and neck cancer
... with DNA damaging agents including platinum-based compounds and radiation ...cancer. DNA repair proteins of the nucleotide excision repair pathway (ERCC1) and of the base ... See full document
17
DNA damage repair in ovarian cancer: unlocking the heterogeneity
... Nucleotide excision repair (NER) is a highly conserved and versatile pathway used to remove ‘bulky lesions’ caused by UV light and carcinogens such as benzopyr- ene, which would otherwise distort the ... See full document
12
The Relative Roles of Three DNA Repair Pathways in Preventing Caenorhabditis elegans Mutation Accumulation
... three excision repair pathways in eukaryotes has benefited from decades of intense study from a variety of biochemical and molecular genetic ap- proaches, primarily in Saccharomyces cerevisiae and mam- ... See full document
9
Studies on protein:protein interactions in mammalian DNA base-excision repair
... Base excision repair (BER) first became known in 1974 with the discovery of uracil DNA glycosylase, while searching for an enzyme that could remove deaminated cytosines (Lindahl, ...of DNA, ... See full document
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Role of Repair Enzymes - Damage Control of DNA From Ageing pans
... the XPC complex in GG- NER or, presumably, CSB and CSA in TC-NER recruit the multi-subunit (ten protein complex) and the multi-functional transcription factor TFIIH to the site of ...the DNA ... See full document
8
Characterisation of XPD from Sulfolobus acidocaldarius : an iron sulphur cluster containing DNA repair helicase
... six repair factors called RPA, XPA, XPC, TFIIH (Transcription Factor II H), XPG and ...XPA, XPC), although it is unclear in which ...NER. XPC prefers to bind undamaged DNA over CPDs, ... See full document
223
ERCC1 expression and RAD51B activity correlate with cell cycle response to platinum drug treatment not DNA repair
... recombination repair is in part mediated by the RAD51 proteins ...recombination repair in knockout chicken B lymphocyte DT40 cells resulted in sensitivity to cisplatin treatment ...the repair of ... See full document
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