1. Schymick JC, Scholz SW, Fung HC, et al. Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. Lancet Neurol. 2007;6(4):322-8. 2. MedicineNet.com. Amyotrophic lateral sclerosis (ALS or “Lou Gehrig’s
Disease”). 2015 Nov 23 [cited 2015 Nov 23]; Available from: http://www. medicinenet.com/amyotrophic_lateral_sclerosis/article.htm
3. Orrell RW. Understanding the causes of amyotrophic lateral sclerosis. N
Engl J Med. 2007;357(8):822-3.
4. Hardiman O, Greenway M. The complex genetics of amyotrophic lateral sclerosis. Lancet Neurol. 2007;6(4):291-2.
5. Pasinelli P, Brown RH. Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat Rev Neurosci. 2006;7(9):710-23.
6. Dunckley T, Huentelman MJ, Craig DW, et al. Whole-genome analysis of sporadic amyotrophic lateral sclerosis. N Engl J Med. 2007;357(8):775-88. 7. van Es MA, Van Vught PW, Blauw HM, et al. ITPR2 as a susceptibility
gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study. Lancet Neurol. 2007;6(10):869-77.
8. van Es MA, van Vught PW, Blauw HM, et al. Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis. Nat Genet. 2008;40(1):29-31.
9. Chio A, Schymick JC, Restagno G, et al. A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. Hum Mol Genet. 2009;18(8):1524-32.
10. Blauw HM, Veldink JH, van Es MA, et al. Copy-number variation in sporadic amyotrophic lateral sclerosis: a genome-wide screen. Lancet Neurol. 2008;7(4):319-26.
11. Cronin S, Berger S, Ding J, et al. A genome-wide association study of sporadic ALS in a homogenous Irish population. Hum Mol Genet. 2008;17(5):768-74.
12. Cronin S, Greenway MJ, Prehn JH, et al. Paraoxonase promoter and intronic variants modify risk of sporadic amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2007;78(9):984-6.
13. Ahmeti KB, Ajroud-Driss S, Al-Chalabi A, et al. Age of onset of
amyotrophic lateral sclerosis is modulated by a locus on 1p34.1. Neurobiol Aging. 2013;34(1):357 e7-19.
14. Deng M, Wei L, Zuo X, et al. Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis. Nat Genet. 2013;45(6):697-700.
15. Kwee LC, Liu Y, Haynes C, et al. A high-density genome-wide association screen of sporadic ALS in US veterans. PLoS One. 2012;7(3):e32768. 16. Laaksovirta H, Peuralinna T, Schymick JC, et al. Chromosome 9p21 in
amyotrophic lateral sclerosis in Finland: a genome-wide association study. Lancet Neurol. 2010;9(10):978-85.
17. Landers JE, Melki J, Meininger V, et al. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2009;106(22):9004-9.
18. Shatunov A, Mok K, Newhouse S, et al. Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study. Lancet Neurol. 2010;9(10):986-94. 19. Sha Q, Zhang Z, Schymick JC, et al. Genome-wide association reveals
three SNPs associated with sporadic amyotrophic lateral sclerosis through a two-locus analysis. BMC Med Genet. 2009;10:86.
20. van Es MA, Veldink JH, Saris CG, et al. Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. Nat Genet. 2009;41(10):1083-7.
21. Cronin S, Tomik B, Bradley DG, et al. Screening for replication of genome-wide SNP associations in sporadic ALS. Eur J Hum Genet. 2009;17(2):213-8.
22. Landers JE, Melki J, Meininger V, et al. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2009;106(22):9004-9.
23. van Es MA, Veldink JH, Saris CG, et al. Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. Nat Genet. 2009;41(10):1083-7.
Genome-Wide Association Data: Where Are the Standards? 29
24. Laaksovirta H, Peuralinna T, Schymick JC, et al. Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study. Lancet Neurol. 2010;9(10):978-85.
25. Shatunov A, Mok K, Newhouse S, et al. Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study. Lancet Neurol. 2010;9(10):986-94. 26. Ahmeti KB, Ajroud-Driss S, Al-Chalabi A, et al. Age of onset of
amyotrophic lateral sclerosis is modulated by a locus on 1p34.1. Neurobiol Aging. 2013;34(1):357 e7-19.
27. Daoud H, Belzil V, Desjarlais A, et al. Analysis of the UNC13A gene as a risk factor for sporadic amyotrophic lateral sclerosis. Arch Neurol. 2010;67(4):516-7.
28. Kwee LC, Liu Y, Haynes C, et al. A high-density genome-wide association screen of sporadic ALS in US veterans. PLoS One. 2012;7(3):e32768. 29. Deng M, Wei L, Zuo X, et al. Genome-wide association analyses in Han
Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis. Nat Genet. 2013;45(6):697-700.
30. Zeggini E, Weedon MN, Lindgren CM, et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science. 2007;316(5829):1336-41.
31. Szklo M, Nieto FJ. Epidemiology: beyond the basics. Boston, MA: Jones and Bartlett; 2004.
32. Balding DJ, Bishop M, Cannings C, editors. Handbook of statistical genetics. 3rd ed. Chichester, United Kingdom: John Wiley & Sons; 2007. 33. Garson GD. Logistic regression, in Statnotes: Topics in multivariate
analysis. 2008. Available from: http://www2.chass.ncsu.edu/garson/pa765/ statnote.htm
34. Agresti A. Categorical data analysis. 2nd ed. Hoboken, NJ: John Wiley & Sons; 2002.
35. Zheng G, Gastwirth JL. On estimation of the variance in Cochran- Armitage trend tests for genetic association using case-control studies. Stat Med. 2006;25(18):3150-9.
36. Mackenzie IR, Bigio EH, Ince PG, et al. Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations. Ann Neurol. 2007;61(5):427-34.
37. Slowik A, Tomik B, Wolkow PP, et al. Paraoxonase gene polymorphisms and sporadic ALS. Neurology. 2006;67(5):766-70.
38. Balding DJ. A tutorial on statistical methods for population association studies. Nat Rev Genet. 2006;7(10):781-91.