Chapter 10 Concluding Remarks
10.3 Future Directions
where J is the current density and E is the electric field. The volumetric heat generated (Joule effect), QJ, and dissipated per unit area, ˙qA, are defined, respectively, as:
QJ=J·E (2.11a)
and
˙qA=dQJ (2.11b)
whered represents the thickness of the resistive layer.
composed of Fe3O4nanoparticles and PDMS. These have been considered for applications in microchips. The micro-heater has also been shown to amplify the target DNA (732 bp)
with >90 % efficiency compared to the conventional PCR thermocycler. It has also been
shown to exhibit good temperature control.[113]
Our research group has previously reported in-vitro hyperthermiavia a direct voltage driven coil-based implant.[114] This has been shown to kill or reduce the viability of breast cancer cells in the vicinity of the elevated temperature fields that surround the device. The conditions for hyperthermia were achieved by applying a voltage of 1.5 volts to a copper coil (heater) that was embedded in poly-(di-methyl-siloxane) (PDMS). We have also re-portedin-vitrosimultaneous hyperthermia and drug release studies, using paclitaxol loaded thermo-responsive hydrogels of poly-n-(isopropylacrylamide) (PNIPA) incorporated into PDMS.[115, 116] About 90% of the loaded drug was released after 2 days of hyperthermia conditions.[116]
In this work, we explored the use of PDMS based composites as implantable biomedical devices for breast cancer treatment. Two types of composites were investigated: (i) mag-netic nanocomposite consisting of PDMS and magmag-netic nanoparticles and (ii) Joule heating composite consisting of PDMS and metal thin film.
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