Herpesvirus Entry Mediator and Nectin-1 Mediate Herpes Simplex Virus 1 Infection of the Murine Cornea

This study suggests a mechanism whereby LAT up- regulates HVEM expression potentially through binding of two LAT small noncoding RNAs to the HVEM promoter and that the increased

We tested several human tumor cell lines for susceptibility to these viruses and observed that HT29 colon carcinoma cells are susceptible to infection by nectin-1-restricted virus

When B78H1 cells (nectin-1 negative) were transfected (Fig. 10I), gD was expressed on the cell surface; however, we did not observe specific accumulation of gD at cell contact areas

Primary cultures of rat and mouse sensory neurons were used to study the entry of herpes simplex virus type 1 (HSV-1).. Soluble, truncated nectin-1 but not HveA prevented

In conclusion, we have shown that HVEM on radiation- resistant cell types, such as cells of the corneal epithelium or stroma or long-lived, resident APCs, plays an important

The purpose of this study was to determine whether a cell surface protein that can serve as coreceptor for herpes simplex virus type 1 (HSV-1) entry, herpesvirus entry

A soluble form of HVEM (consisting of the ectodomain of HVEM fused in frame to the C H 2 and C H 3 domains of rabbit immunoglobulin G [IgG] heavy chain), HVEM:Fc, blocks HSV type

Since sex has also been shown to play a role in the immune response to viral infection, we investigated whether female mice of the WT and HVEM KO genotype exhibit a response to