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Siegfried

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The Siegfried Group achieved sales of CHF 283 million, a 2.2% decrease over the previous year. Sales of active ingre-dients (Siegfried Actives) grew 15.3% to CHF 220.9 million. The Siegfried Generics Division reported sales of CHF 62.1 million, a drop of 36%.

Operative cash flow was a bright spot: increasing by 69.4% to CHF 45.5 million. Net working capital were reduced by CHF 39 million to CHF 133 million, which had a positive effect on cash flow, but reduced our operative results. Net debt was reduced by CHF 7.9 million to CHF 63.3 million. The EBITDA of CHF 25.3 million (excl. the “Deliver” program restructuring costs) for the Siegfried Group is 8.9% of total revenue. The “Deliver” restructuring project achieved sav-ings of about CHF 10 million.

For 2009, the Siegfried Group increased sales of the core business active pharmaceutical ingredients by 15.3% over the previous year and achieved an EBITDA of CHF 25.9 mil-lion and an EBITDA margin of 11.7%; compared to the industry average, these are solid results.

Generics sales in 2009 were, once again, strongly affected by the profound changes in the German market. However, the shortfall to 2008 was successively reduced during the year.

In 2009, CHF 4.2 million were dedicated toward our “Deliver” restructuring program. Various balance sheet items were reviewed and adjusted. Including the investments in the PulmoJet®inhalation technology, a net loss of CHF 35.3 million was resulting.

Comparisons with 2008 are set apart by two exceptional factors: a one-time license payment of CHF 13.5 million for a biogeneric and an accounting profit of CHF 13.4 million resulting from the sale of the Zofingen pharmaceutical production facility to Arena.

The balance sheet of the Siegfried Group remains robust with a 68.6% self-financing level.

A quick implementation of our growth strategy demands measures for both organic and external growth, and will have a profound effect on the different Siegfried Group facilities. Both will require substantial financial resources, which is why the Board of Directors recommends that the General Meeting of Shareholders approve a capital increase of CHF 80 million.

Our majority stockholder, the Camellia Group (U.K.) will not participate in the capital stock increase. Due to the recommended capital increase and the result for 2009, the Board of Directors recommends that the General Meeting of Shareholders abstain from issuing a dividend.

After 43 years of service to the company, Dr. Bernard Siegfried, Honorary Chairman of the Siegfried Group, has retired from the Board of Directors.

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Siegfried Group 2009 2008 Change

Net sales (million CHF) 283.0 289.3 –2.2%

Net loss (million CHF) –35.3 –74.9 –52.9%

Gross profit (million CHF) 47.5 62.4 –23.9%

Operating result before special charges (million CHF) –7.3 14.8 n.a.

Operating margin before special charges (%) –2.6% 5.1%

Operating result (EBIT) (million CHF) –27.7 –84.7 –67.3%

Operating margin (EBIT) (%) –9.8% –29.3%

Cash flow from operating activities (million CHF) 45.5 26.8 69.4%

EBITDA before special charges (million CHF) 25.3 52.0 –51.4%

EBITDA margin before special charges (%) 8.9% 18.0%

EBITDA (million CHF) 21.0 52.0 –59.6%

EBITDA margin (%) 7.4% 18.0%

Shareholder’s equity (million CHF) 327.3 352.0 –7.0%

Total assets (million CHF) 477.1 539.5 –11.6%

Equity as a % of total assets 68.6% 65.2%

Capital expenditure (million CHF) 20.8 30.5 –31.7%

Personnel expenses (million CHF) 101.3 98.4 3.0%

Employees1 823 826 –0.4%

Dividend (million CHF)2 5.9

Dividend (CHF per share)2 2.10

Development of base business3

Net sales (million CHF) 283.0 275.8 2.6%

Operating result before special charges (million CHF) 6.1 2.2 138.6%

Operating margin before special charges (%) 2.1% 0.8%

EBITDA before special charges (million CHF) 37.1 38.4 –3.5%

EBITDA margin before special charges (%) 13.1% 13.9%

1 at balance sheet date

2 For 2009 as per proposal to the general meeting of shareholders on a maxiumum of 2 800 000 shares ranking for dividend (dividends on treasury shares not

paid to shareholders will be carried forward)

3 Development of base business excluding expenses for the build up of the Inhalation technology. Prior year additionally excluding gain from sale of fixed assets

(Arena) and nonrecurring licensing fees.

Key numbers

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Table of Contents 2009 Overview

Letter from Chairman & CEO 2

Corporate Governance

0. Foreword and General Framework 13

1. Structure of the Siegfried Group 14

2. Capital Structure 17

3. Board of Directors 18

4. Executive Management 29

5. Compensation, Investments and Loans 33

6. Voting rights and proxy 35

7. Control changes and defensive measures 36

8. Auditors 36

9. Information policy 37

Sustainability Report

Introduction 41

Compliance 46

Safety, Health & Environment (SHE) 48

Siegfried as an Employer 60

Social Responsibility 63

Consolidated Financial Statements Siegfried Holding AG

Editorial 66

Consolidated Balance Sheet 68

Consolidated Income Statements 69

Consolidated Cash Flow Statements 68

Consolidated Income Statement 69

Consolidated Statement of Comprehensive Income 69

Consolidated Statement of Cash Flows 70

Consolidated Statement of Changes in Equity 71

Notes to the Consolidated Financial Statements 72

Employee Benefits 77

Risk Management 78

Financial Risk Management 79

Report of the Statutory Auditor 104

Five-year overview 2005–2009, consolidated figures 105

Financial Statements Siegfried Holding AG

Balance Sheet of Siegfried Holding AG 108

Income Statement of Siegfried Holding AG 109

Notes to the Financial Statements of Siegfried Holding AG 109

Proposal for the appropriation of accumulated losses and free reserves 112

Report of the Statutory Auditors 113

Stock market data 114

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2 Annual Report Dear Shareholders,

In 2009, Siegfried achieved sales of CHF 283 million (core business), an increase of 2.6% over the previous year. Group income decreases by 2.2% when compared to the total Group income in 2008, i.e. including a one-time license pay-ment of CHF 13.5 million for a bio-generic. The Siegfried Actives Division grew sales by 15.3% to CHF 220.9 million. The Siegfried Generics Division noted a 26.2% decline (core business), or 36.4% with the above noted license payment. Faced with unfavorable economic conditions and the finance crisis, Siegfried focused primarily on managing both cash and net current assets in 2009. As a result, current assets were reduced by over 20% (CHF 39 million) to CHF 133 mil-lion over the year. This resulted in a positive cash flow of CHF 45.5 million, 69.4% above the cash flow of 2008. Net debt was reduced by CHF 8 million and is at a reasonable level (ca. CHF 63 million).

The EBITDA of CHF 37.1 million (excl. special costs) corre-sponds to an EBITDA margin of 13.1%. Siegfried posted an EBIT of CHF 6.1 million (excl. special costs) for 2009. A new review of projects in both Divisions made an adjustment of CHF 16.2 million for activated development costs necessary. Including special costs and the costs of the “Deliver” project, the company noted a loss of CHF 14.4 million.

The financial results include interest costs. Further, during the second half of the year our holdings in Arena Pharma-ceuticals (U.S. company) were adjusted by almost CHF 7 mil-lion. Overall, the net losses from our share holdings amount-ed to CHF 35.3 million. These shares were acquiramount-ed in 2008 as partial payment for the Zofingen production facility sold to Arena. Despite the positive trial results released in the fall of 2008 for its key Lorcaserin product, the share price con-tinued to decline. We decided to adjust the value of our holdings although we firmly believe in the huge potential of this product (which is produced in Zofingen). The shares held by Siegfried are locked until the end of 2010.

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As a supplier to the Life Science industry, Siegfried is active in three market segments. Our most important market is customized synthesis of patent-protected ingredients to support the research efforts of the pharmaceutical industry. Siegfried also offers active pharmaceutical ingredients with expired patents to various customers. These ingredients include controlled substances (incl. opiates), such as methadone and nicotine, used in addiction treatments, and other substances that must meet specific guidelines. In the U.S. they are strictly controlled by the American regulatory agencies. The third market is for finished medications, mostly for the generics industry.

In the discussion concerning the company strategy, the Board of Directors and executive management looked to identify competitive advantages for Siegfried. Because the custom synthesis market is very fragmented, with only a 5% share for the market leader, answering this question is of critical importance. Further, there is little room for revolu-tionary technological innovations in this market, with

experi-ence, absolute reliability and the greatest possible degree of flexibility being the most desirable traits for an outsourcing partner. As a previously fully integrated pharmaceutical com-pany, Siegfried is one of the few suppliers in this market that offers capabilities on both the primary and secondary pro-duction levels. We are able to produce not only the active in-gredient but also the finished medication. Such a decades-old tradition of know-how and experience is truly unique for a supplier of production services – and this “everything un-der one roof” approach forms the bedrock for our new strategic direction. Because the benefits of this strategy can only be realized when both competencies are available at the same site, the implementation of our new “Transform” strategy will have profound affects on our various produc-tion facilities. Currently, only our Zofingen site offers both types of development services.

In addition to the ability to both develop and manufacture active pharmaceutical ingredients, “Transform” also looks to expand our range of production technologies. For example,

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4 Annual Report

preconditioning the physical characteristics of active ingredi-ents during the end production phase (by spray drying with mixing of additives) is how Siegfried can manage projects for innovative pharmaceutical clients. The needed expertise is now being ramped up for integration in various situations. We are also investing in the management of special class substances, such as the spray drying of active ingredients and a micro-reactor that were introduced and used success-fully in a number of projects. A further example is a signifi-cant process optimization for a large pharmaceutical account in Switzerland. In addition to the already mentioned com-mercial systems, the pilot systems were also upgraded for highly active ingredients. Now a full range of substances up to sample sizes of 1μg can be safely handled. Upgrading of our formulation capabilities is also planned; and we already have access to our commercial formulation system in Malta. We also see great potential in this area by combining API and formulation, as foreseen by the new corporate strategy.

The new strategic decisions led to a number of correspon-ding structural changes. Since maintaining two independent divisions was no longer part of our strategy, the Board of Directors and executive management chose a new Group management structure that was launched on March 1, 2010. While Dr. Rudolf Hanko (CEO), Michael Huesler (CFO), Hanspeter Brun (Head of HR), all continue in their previous responsibilities, Marianne Spaene was appointed Head of Business Development & Sales and Dr. Hubert Stueckler is responsible for Global Technical Operations. Peter Gehler assumed responsibility for the Corporate Center, which in-cludes Communications, the legal department, Facility Management and the Chairman’s Office. The Development department is once again an independent unit and will be temporarily led by Dr. Rudolf Hanko. The new organization will enable Siegfried to clearly position the competencies of both Divisions as a unit – both in the market and internally with our processes. Our efforts, both internally and external-ly, will continue to focus on the most important customer segments.

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Parallel to the new strategic direction, extensive efforts were made to keep the “Deliver” turnaround project on track. The chemical production department was split into three “focused factories” to better realize key efficiency gains; each factory now processes a specific type of customer con-tract. The new development lab building in Zofingen (built at a cost of CHF 17 million) brought the analytic teams to-gether under a single management to reduce complexity and allow considerable synergies. Overhead costs were also markedly reduced and we even surpassed our cost-savings goal of CHF 9 million. An additional CHF 10 million in savings is planned for 2010 and will be visible in the finan-cial results.

In 2009, the Siegfried Actives Division increased both sales and output. Sales grew by 15% and a larger number of ex-clusive synthesis customers placed mid-sized to large orders. This is the first step toward reducing the average age of our product portfolio with active pharmaceutical ingredients and intermediates for new drugs at the beginning of their life

cycle. These are products that just were, or are about to be launched on the market by the client. The improvements in the product portfolio are complemented by a qualitative and quantitative upgrade of our development pipeline, which currently features 40 exclusive synthesis projects. In the con-trolled substances market in the U.S., we continue to focus on the development of our opiate products, i.e. active phar-maceutical ingredients used in analgesics for pain therapy. After delays in the past years, an important contract was signed with a large U.S. account; initial deliveries are set for 2010. A second contract was signed at the start of 2010; the registration phase for this key account is being initiated as quickly as possible, with initial sales expected by the sec-ond half of 2011. Despite the positive outlook, we’ve taken a new financial accounting approach and depreciated CHF 9 million in activated opiate development costs.

The generics business in 2009 was strongly influenced by the profound changes in the German market. However, the shortfall to 2008 was successively reduced during the year, From left to right:

Markus Altwegg, Ph.D., President of the Board of Directors Rudolf Hanko, Ph.D., CEO

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6 Annual Report

reaching 25% by the end of 2009. Progress was made in di-versifying and increasing sales to countries that were previ-ously ignored or only minimally served, but this did not fully compensate for the sales shortfall in Germany. As part of the revised “Transform” strategy, the Siegfried Generics Division was already actively conducting development work in 2009 for numerous exclusive customers. The Division’s pipeline was basically realigned, which led to depreciation of CHF 7 million in activated development costs. In the future, Siegfried will expand development technology for finished medications beyond tablets and capsules. To minimize risk, projects are being carried out and financed only with exter-nal partners since mid-2009.

Development of the PulmoJet®inhalation device advanced to the point that a pharmaceutical product study could be started in October 2009. Expert reports are very optimistic and we expect the study results by the end of March 2010. Because of the extensive product know-how and financial resources needed to quickly move through the next

develop-ment phases for the PulmoJet®, the Board of Directors and executive management are looking for a partner that can take this device through the clinical study phase. Discussions with numerous interested parties are already at an advanced stage.

Since 2008, Siegfried has increasingly dedicated itself to is-sues of sustainability in all aspects of our business. The inte-gration of our Sustainability Report in our annual report also underlines the importance of this topic. For us, sustainability means doing our work carefully and with a long-term view. Carefully, because we deal with demanding substances and need to ensure the safety of both our employees and the en-vironment. Long-term, because our commercial success also secures jobs. Siegfried has performed well in the areas of compliance and quality, safety, health & environment, and as an employer. Compliance was spotless in 2009; even with the numerous inspections and audits, there were no com-plaints. Levels of employee safety were clearly raised, con-firmed by the decline in accidents; two sites posted perfect

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records with no accidents. The insurance company, HDI Ger-ling rated Siegfried among the global ‘Top 10’ of inspected companies. Health awareness was promoted through vari-ous activities, such as participation in the “Bike to Work” campaign and nutritional workshops for shift workers. The overall reduction of our CO2emissions and the close cooper-ation with the “Climate Cents” Foundcooper-ation highlighted our environmental efforts.

The Board of Directors met seven times in 2009, including an off-site 2-day strategy workshop and an assessment meeting to review their performance. Also, the different committees closely accompanied the new strategic priorities and structural changes.

We would like to sincerely thank the members of the Board of Directors, the executive management, and every em-ployee around the world for their enormous commitment. The gravity of the current situation has been recognized and we are confident that we can count fully on the support of

our people during these difficult times. We greatly value this quality, as it forms the inner strength of our company. During the global financial crisis, financing the corporate strategy – and the future of the company – is of particular importance. During the strategy discussions, the Board of Directors and executive management saw the risk of financ-ing the new strategy with the available financial means. Neither a robust balance sheet nor a high equity ratio will ensure a loan. This is why the Board of Directors advises ex-ecutive management to secure a capital infusion of CHF 80 million. At the same time, the Camellia Plc., Linton (UK), the largest single shareholder in Siegfried Holding AG, informed the company that it was unwilling to participate in a new share issue for portfolio reasons and would seek to sell its holdings. Camellia has asked the Board of Directors and executive management for support in this endeavor. The Siegfried Group honorary Chairman, Dr. Bernard A. Siegfried, informed us that he would not be available for

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election. Bernard Siegfried first joined the company in 1967 after graduating from the University of St. Gall and further-ing his professional development overseas. He introduced a comprehensive corporate planning process and managed the company reorganization. He was promoted to executive management in 1973 and elected to the Board of Directors and made CEO of Siegfried AG in 1977. After a memorable Shareholder’s Meeting in 1991 he transformed the company and built a specialized company for manufacturing of active pharmaceutical ingredients and finished dosage forms. In the anniversary year 1998 he was elected Chairman. In 2000, he withdrew from all operative functions and in 2003 he also resigned as Chairman of the Board of Directors. He remained a member of the Board and was appointed Hon-orary Chairman of Siegfried Holding AG.

Important points for you as shareholder:

– In 2009, Siegfried grew core business activities and posted good overall sales results.

– Operative cash flow was gaining 69.4% to CHF 45.5 mil-lion in 2009; net debt was reduced to CHF 63 milmil-lion. – Both the operative results and net profit are characterized

by a consistent reduction of net working capital and de-preciation of the activated development costs and other adjustments.

– During the year a new corporate strategy (“Transform”) was adopted; the new strategy will affect the company structure at the different sites.

– A capital infusion to finance our new strategy is unavoid-able despite a robust balance sheet. The Board of Direc-tors recommends that the General Meeting of Sharehold-ers approve a capital increase of CHF 80 million. Our majority shareholder (Camellia Plc.) will not participate in the share issue; its holdings in Siegfried are now for sale.

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– Due to the recommended capital increase and the result for 2009, the Board of Directors recommends that the General Meeting of Shareholders waive the annual dividend.

– After over 40 years of service to the company, Honorary Chairman Bernard A. Siegfried is resigning from the Board of Directors.

We thank you for your interest and trust in Siegfried.

Markus Altwegg, Ph.D. Rudolf Hanko, Ph.D. Chairman of the Board of Directors Chief Executive Officer

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For me, efficiency is more than just finishing something quickly. It com-bines speed with a sense of effortless-ness and the determination to elimi-nate anything unnecessary. It’s about constant improvement and enjoying your work. Often, increasing efficiency is really many small steps that add up to very noticeable progress. It’s also not always a matter of saving time; a well-designed workflow that is safe and not hectic is equally important. A lot of this can be learned, but primarily you need a drive, an inner “fire” and lots of ex-perience to be able to recognize what’s important. The perfect workflow is swift, easy and it can be a lot of fun. Since starting at Siegfried as an Opera-tions Manager about 12 years ago, I was always able to influence and make a direct contribution to my work environment. My decisiveness was also highly valued by my superiors. Being responsible for three production lines demands that decisions are made – constantly. Only rarely do you have time to carefully weigh the pros and cons of a situation. This is where expe-rience – my own and that of my closest and most important colleagues, the plant foremen – makes the difference, because a decision will always be made.

Our organization’s matrix structure also facilitates sharing know-how with others. One of the most satisfying as-pects of my job is start a new process

with the product chemist. This includes discussing possible procedural and chemical stumbling blocks, point out more efficient possibilities, and ensure that the offline and waste flows are not forgotten. When you work with the production planners, the safety specialists, and also with the whole regulatory area and the analytical team, no day is like the other. In addi-tion, we have customer and regulatory audits almost every week. They, too, should feel the “fire” that drives us and our commitment to doing a job well.

I also enjoy teaching. For the past 11 years I’ve taught ‘chemical technol-ogy’ every week at a vocational school. The budding chemical and pharmaceu-tical specialists there appreciate my enthusiasm and not insignificant expe-rience. As president of my community’s school board I am also involved in making the most of the available school budget for the good of the children.

When my family – my wife, Eveline and our sons, 5 and 7 years old – is out swimming, riding bikes or hiking, the boys set the pace. I enjoy our time to-gether immensely, even when my wife is on a multi-day birding expedition, taking care of bats or leading an excur-sion while the boys and I have our time together and I immerse myself in their world. My wife also leaves me time for my fastest hobby, which is not

moun-tain-biking or skiing, but takes place on various racetracks across Europe. Numerous times every year I convert my KTM 1000 Superduke motorbike from street to race trim, put it on the trailer and head for the track – to see just how fast I can go. The perform-ance of today’s bikes can only be fully enjoyed on the track and when a day of turning in laps goes well and with-out a spill, I’m in the “flow,” where I feel as one with the machine, my con-centration is optimal and the effort seems almost playful. My sense of sat-isfaction after a successful day is huge and, similar to other hobbies (and my family), is a large part of my positive ‘work/life balance.’

Roland Schuermann

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12 Corporate Governance

Table of contents

0. Foreword and general framework

1. Siegfried Group management structure & shareholders 2. Capital structure

3. Board of Directors 4. Executive management

5. Compensation, investments and loans 6. Participatory rights of shareholders 7. Controlling and defensive measures 8. Auditors

9. Information policy

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0. Foreword and general framework

Regarding corporate governance, the Siegfried Group takes an integrated approach and is fully committed to mutual trust and clarity toward shareholders, employees, business journalists and financial analysts.

Our experience with the SIX Swiss Exchange guidelines has shown the importance of stable and long-term relationships with all shareholders and stakeholders, and a sensible appli-cation of corporate governance instruments.

Cooperate governance at Siegfried is based on the statutes of Siegfried Holding AG, the rules of procedure of the Siegfried Group, and the structure of the Group and the two Divisions, Siegfried Actives and Siegfried Generics. This re-port describes the principles of management and control of the Siegfried Group. Corporate governance of the Siegfried Group substantially follows the “Swiss Code of Best Prac-tice” of March 2002. In accordance with the Transparency law (Transparenzgesetz Art. 663b and Art. 663c) the remu-nerations, stock ownership by the members of the Board of Directors and executive management are now disclosed in the notes of the statutory financial statements of Siegfried Holding AG.

Corporate governance of the Siegfried Group is regularly reviewed and adjusted by the Board of Directors.

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1. Structure of the Siegfried Group

1.1 Management structure of the Siegfried Group (until February 28, 2010)

Corporate Governance Siegfried Holding Markus Altwegg, Ph. D. Chairman Siegfried Group Rudolf Hanko, Ph. D. CEO (since 05/01/09) Corporate Communications Peter A. Gehler CCO, Secretary to the BoD

Human Resources

Hanspeter Brun Head Human Resources

Division Generics

Marianne Späne President Siegfried Generics

Finance

Michael Hüsler CFO (since 07/01/09)

Division Actives

Hubert Stückler, Ph. D. President Siegfried Actives

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Participation structure of Siegfried Holding AG

Currency Share Capital in LC Participation Comments

1. Switzerland

Siegfried Ltd, Zofingen CHF 20 000 000 100.00%

Siegfried Pharma Int. AG CHF 100 000 100.00%

Siegfried Generics International AG, Zofingen CHF 2 000 000 100.00%

Siegfried Finance AG, Zofingen CHF 14 000 000 100.00%

Sigamed AG, Zug CHF 500 000 100.00%

2. Europe

Siegfried GmbH, Munich EUR 25 000 100.00%

Siegfried Pharma Development GmbH, Munich EUR 25 000 100.00% Siegfried Generics (Malta) Ltd., Valletta EUR 100 000 100.00% Siegfried Deutschland Holding GmbH, Bad Säckingen EUR 1 790 000 100.00%

Paid-in nominal capital: [Siegfried B.V., Amsterdam (in Liq.)] EUR 80 000 100.00% NLG 35,000 (20%)

3. North and Central America

Siegfried (USA), Inc., Pennsville USD 500 000 100.00%

Penick Holding Company, Pennsville USD 2 100.00%

Penick Corporation, Pennsville USD – 100.00%

4. Asia

SCI Pharmatech Inc., Taiwan TWD 361 617 420 16.11%

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1.2 Shareholders Major shareholders

The following table describes the shareholder structure of Siegfried Holding AG and lists shareholders reporting hold-ings of 3% or more of the voting rights of Siegfried Holding AG. In addition, the shareholdings of the Board of Directors and of the Group Management are shown.

Shares held Shares held

as of 31.12.2009 % as of 31.12.2008 %

With holdings over 3%

Camellia Group (consisting of

Camellia Holding AG, Glarus; Affish Ltd, Linton) 933 680 33.35 933 680 33.35 Siegfried Shareholders’ Group (consisting of

descendants of Dr. h.c. Hans Siegfried and Sigamed AG, Zug) 103 630 3.70 102 897 3.67

Tweedy, Browne Company LLC, New York1 275 361 9.83 287 532 10.27

Bayerninvest Kapitalgesellschaft mbH, Munich

(100% subsidiary of Kreissparkasse Biberach)2 106 106 3.79

Total 1 418 777 50.67 1 324 109 47.29

Board of Directors and Group Management

Board of Directors, non-executive3 23 971 0.86 16 491 0.59

Board of Directors, executive and Group Management 2 945 0.10 7 257 0.26

Total 26 916 0.96 23 748 0.85

Others

Public shareholders 1 342 385 47.94 1 443 381 51.55

Shares held by Siegfried Holding AG 11 922 0.43 8 762 0.31

Total 1 354 307 48.37 1 452 143 51.86

Grand total 2 800 000 100.00 2 800 000 100.00

The Camellia Group and the Siegfried Shareholders Group have granted each other the right of first refusal relative to the sale of shares held by them.

1By its own account, Tweedy Brown LLC, New York, held 9.83% of the shares of Siegfried Holding AG; 3% of these shares are registered in the share register

with voting rights.

2By its own account, Bayerninvest, Munich, Germany held 3.79% of the shares of Siegfried Holding AG; Bayerninvest has not applied to register these shares

in the share register.

3Excluding the shareholdings of Dr. Bernard A. Siegfried, which are included under “Siegfried Shareholders’ Group.”

Corporate Governance

1.3 Crossholdings

The Siegfried Group has not entered into any crossholdings with other companies involving capital or voting.

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2. Capital structure

2.1 Capital

The share capital of Siegfried Holding is CHF 5,600,000 and is divided into 2,800,000 fully paid-up registered shares with a par value of CHF 2 each.

2.2 Changes in capital during the past three reporting years

There were no changes in capital during the last three years.

2.3 Limitations on transferability and registration

Only persons entered in the share register can exercise the right to vote and the privileges related thereto. Registration is subject to the following statutory restrictions:

– Registration requests are considered granted if the com-pany has not denied them within 20 days after receipt. – Petitioners must declare in writing that they have acquired

the shares in their own name and account.

– The Board of Directors must deny the request if the peti-tioner alone or together with associated persons controls more than 3% of the voting rights after approval. – Upon presentation of relevant reasons,

the Board of Directors may approve exceptions. – To the extent that federal regulations require that the

company be controlled by Swiss citizens, the Board of Directors must deny the request if the registered foreigner already controls over 10% of the voting rights or would do so after registration.

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Board of Directors From left to right:

Bernard A. Siegfried, Ph.D., Susy Brüschweiler, Markus Altwegg, Ph.D., Thomas Staehelin, Ph.D., Prof. Felix Gutzwiller, M.D., Felix K. Meyer, Ph.D.

(Malcolm Perkins is not included in the photo)

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3. Board of Directors

The tasks of the Board of Directors are governed by law and are set forth in the statutes and company regulations of the Siegfried Group.

3.1 Members of the Board of Directors

The Board of Directors of Siegfried Holding AG comprises seven persons. The members of the Board of Directors have no significant business relationships with Siegfried Holding AG or the Siegfried Group.

The following table gives information about the name, age, position, and date of entry and duration of term in office of the members of the Board of Directors:

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Name Birthyear Position Entry Elected until

Markus Altwegg 1941 Chairman, non executive 2002 2011

Thomas Staehelin 1947 Vice-Chair, non-executive 1991 2012

Bernard A. Siegfried 1934 Honarary Chair and member, non-executive 1977 2010

Susy Brüschweiler 1947 Member, non-executive 1999 2011

Felix Gutzwiller 1948 Member, non-executive 1999 2011

Felix K. Meyer 1953 Member, non-executive 2006 2012

Malcolm Perkins 1945 Member, non-executive 2008 2011

Secretary to the Board of Directors:

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3.2 Profiles

Markus Altwegg, Ph.D., Chairman

Markus Altwegg (1941) joined the Board of Siegfried Holding AG in 2002 and became Chairman in 2003. At the Roche Group, he was responsible for the worldwide opera-tions of the Vitamin & Fine Chemicals Division from 1999 until his retirement in 2003. Prior to that he held various positions within different departments at Roche since 1968 and was appointed to the Executive Committee in 1986. Markus Altwegg serves on the Board of the Energiedienst Holding AG and the private bank Sal. Oppenheim AG. Furthermore, he is a member of numerous industry associa-tions and scientific and charity organizaassocia-tions. He is Chairman of the committee of the Basel Museum of Art, a committee member of the Basel Museum of Ancient Art and Chairman of the committee of the Technology Transfer Organization (WTT) of the University of Basel.

He has a Ph.D. in Economics from the University of Basel. Markus Altwegg is a Swiss citizen.

Thomas Staehelin, Ph.D., Vice Chairman

Thomas Staehelin (1947) was appointed Vice Chairman of Siegfried Holding AG in 1999; prior to that he served as the company’s Chairman from 1991 and 1998. Thomas Staehelin is a partner in Fromer, Schultheiss und Staehelin, a law firm in Basel. As a lawyer, he specializes in tax, corporate, and contract law.

Thomas Staehelin is Chairman of the Basel Chambers of Commerce and a board member and chairman of the tax and finance committee of the Swiss Business Federation (economiesuisse). He is a member of the Board of the Asso-ciation of Private Joint Stock Companies and a member of the Expert Committee on Financial Reporting (SWISS GAAP FER). Thomas Staehelin serves on the Board of Directors of the following companies: Chairman of Swissport Interna-tional AG, Kühne Holding AG, and Scobag Private Bank AG, Board member of Kühne & Nagel International AG, Lantal Textiles, and Inficon Holding. In a few of these companies he also chairs the auditing committee.

Thomas Staehelin is a Swiss citizen.

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Bernard A. Siegfried, Ph.D., Honorary Chairman Bernard A. Siegfried (1934) was Chairman of Siegfried Holding AG from 1998 to 2003. After furthering his profes-sional development in Mexico and the USA, he joined the family-owned company in 1967. In 1977 Bernard A. Siegfried was appointed Chief Executive Officer, and on January 1, 2001 he withdrew from all operative functions. In recognition of his services to the company, the Board of Directors appointed him Honorary Chairman in 2003. He continues as a regular member of the Board of Directors. Bernard A. Siegfried has a Ph.D. in Economics from the University of St. Gall (HSG) in Switzerland. He is a member of the Board of Directors of Camellia, PLC, Linton (UK). Bernard A. Siegfried is a Swiss citizen.

Susy Brüschweiler

Susy Brüschweiler (1947) was appointed to the Board of Siegfried Holding AG in 1999. A trained nurse, she studied economics and business management at the University of Neuchâtel. From 1986 to 1990 she directed the Bois-Cerf Nursing School in Lausanne, Switzerland; and from 1990 to 1994 she was headmistress of the School for Nursing Management in Aarau, Switzerland. In 1995 she joined the former SV-Service (market leader in Swiss catering services) as CEO, transforming the association into the SV GROUP Inc., which she heads as CEO today.

Susy Brüschweiler is a member of the Boards of Schweiz-erische Mobiliar Holding AG and the SchweizSchweiz-erische Mobiliar Association (an insurance company), and Movis AG. She serves on the Board and the Board Committee of the Swiss Employers’ Association. In December 2009, she joined the Board of the Swiss Paraplegic Foundation, Nottwil. Susy Brüschweiler is a Swiss citizen.

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Prof. Felix Gutzwiller, M.D.

Felix Gutzwiller (1948) joined the Board of Siegfried Holding AG in 1999. Since 1988 he is a professor and head of the Preventive Medicine Department at the University of Zurich. He is a member of the Swiss Parlament (Senate).

Felix Gutzwiller completed his studies at the universities of Basel, Harvard, and Johns Hopkins (U.S.A.).

In addition to Siegfried Holding AG, Felix Gutzwiller is also on the Boards of Rahn AG, Medi-Clinic (Switzerland) AG, Bank Clariden Leu AG, Axa Winterthur Schweiz AG, and Osiris Therapeutics, Inc. He serves on the Board of Trustees of numerous charity, scientific and public health founda-tions. Felix Gutzwiller is a Colonel in the Swiss Army. Felix Gutzwiller is a Swiss citizen.

Felix K. Meyer,Ph.D.

Felix K. Meyer (1953) joined the Board of Siegfried Holding AG in 2006. He worked for Ciba-Geigy AG (later Ciba Specialty Chemicals) from 1981-2004, and held various posi-tions in Switzerland and abroad, ultimately, as a Segment Manager and member of the Board. During this time he fo-cused corporate strategy and marketing issues, representing the company in joint ventures in Europe and Asia (China and Japan). From 2004 to 2009, Felix K. Meyer was CEO of the Baerlocher Group, a global specialty chemicals company with headquarters in Munich, Germany.

Since January 2010, he is a member of the advisory board of the Baerlocher Group.

He received his Ph.D. in Chemical Engineering from the ETH in Lausanne, Switzerland and spent a year in Stanford University (U.S.A.) as a Post-doctoral Fellow.

Felix K. Meyer is a Swiss citizen.

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Malcolm Perkins

Malcolm Perkins (1945) joined the Board of Siegfried Hold-ing AG in 2008. He was ManagHold-ing Director since 1974 and Chairman since 1996 of Linton Park Plc, a listed company within the Camellia Plc Group. In 1999, he joined the Board of Camellia and was elected Chairman in 2001. His responsi-bilities for the Camellia Group have necessitated him work-ing in the UK, East and Southern Africa, the U.S.A. and the Indian subcontinent.

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3.3 Linking directorates

3.3.1 Corporate linking directorates

Malcolm Perkins is Chairman of the Board of Directors and Bernard A. Siegfried is a member of the Board of Camellia, Plc, Linton.

There is no other mutual representation between the Boards of Siegfried Holding AG and those of other listed companies.

3.3.2 Linking directorates within the Board

All directorates in other listed companies of the members of the Board of Siegfried Holding AG are described under Section 3.2 “Profiles”.

3.4 Election and period of office

The Board of Directors of Siegfried Holding AG is elected by the General Meeting of Shareholders and subsequently constitutes itself. Members of the board are elected in a staggered sequence for a period of three years and can be re-elected. Regulations specify that members must retire from the Board of Directors at the General Meeting of Shareholders following their 68th birthday. A special ruling can be made for the Chairman or the Honorary Chairman.

3.5 Internal organization

The Board of Directors is responsible for supervision of the Group and the Divisions. The Board determines group strategy, the allocation of resources and the structure of the Group. It is also responsible for setting the organizational structure, accounting, financial control, and financial plan-ning. To the extent it does not exercise these duties itself or delegate them to the Chairman of the Board of Directors, the Board delegates management of the business to the CEO of the Siegfried Group, who is responsible for manage-ment and for all matters not otherwise delegated to another company body by law, statutes or organizational regulations.

Decisions are made by the entire Board of Directors. Four committees assist them:

– Audit & Finance – Human Resources

– Nomination & Compensation – Products & Market

The responsibilities and competencies of the committees are set forth in the adjoining excerpt from the company regulations of the Siegfried Group.

During the business year, the Board of Directors met for six meetings, an assessment meeting and a strategy seminar. All members of the Board of Directors (with one exception) were present. The assessment meeting analyzed the cooperation within the Board and evaluated how goals were achieved.

During the year, the Audit & Finance committee met four times, the HR committee, the Nomination & Compensation committee, and the Products & Markets committee all met two times. The following table shows the composition of the Board committees:

Committee Chair Members

Audit and Finance Thomas Staehelin Susy Brüschweiler

Human Resources Susy Brüschweiler Felix K. Meyer

Nomination & Compensation Markus Altwegg Thomas Staehelin Felix K. Meyer,

Products & Market Felix Gutzwiller Malcolm Perkins

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3.6 Executive management information and control instruments

Information is based on monthly reporting that is structured as follows: results for the Group, the Divisions, and individ-ual sites are presented in detail and compared with the budget and the previous year’s results – including a results forecast for the entire year. Monthly comments focus on any

deviations from plan, important business incidents, and key performance indicators. A fully consolidated financial state-ment is prepared every quarter.

The results are discussed and evaluated with the CEO, the CFO, and with the Division managers at the Board of Directors meetings.

Excerpt from the company regulations of the Siegfried Group

3.3.3 Committees appointed by the Board of Directors

The Board of Directors may appoint committees, at least for such topics as personnel (HR committee), products / market (Products & Markets committee), nomination and compensation (Nomination & Compensation committee) and audit and finance (Audit & Finance committee). Such committees also deter-mine, at an early stage, the risks in various business activities through contact with the responsible authorities, and informing the Board of Directors. They do not have powers of decision (exception: the Nomination & Compensation committee on the compensation for the Group Management), but do have a comprehensive right of information as well as issuing recommendations to the Board of Directors. They may request items to be included on the agenda at the next meeting of the Board of Directors, and report on their activities at the Board meetings. As a rule, two members of the Board shall be included on a committee, one of whom shall be the Chairperson. The committees meet as often as is necessary, at least, however, twice a year.

The issues to be covered include:

Human Resources:

– Personnel policies of the Group and the Divisions

– Maintaining company know-how, training and continued education – Being an attractive employer

– Parameters for negotiations between management and labor – Employee surveys and their evaluation

– Talent promotion, management development – All pension plans and other social benefits

provided by the Group companies

Products/markets

– Pipelines

– Supply structure, services, products

– Market processing, instruments, geographic presence – Market coverage, market data, market evaluation

Nomination/compensation

– Nominations to the Board, the Board of Director committees, Division heads and Holding functions

– Compensation policy of the Siegfried Group – Compensation recommendations for Board members,

submitted to the entire Board

– Setting the employment conditions and compensation for Division heads, Holding functions, and members of the executive management – Bonus systems and stock and option programs

Auditing/finances

– Accounting

– External and internal auditing

– Budget, medium-term and long-term planning – Financial planning

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When I speak people hear that I’m from Austria. And like many of my – often very famous – fellow country-men, I’ve seen a good bit of the world too. My interest in foreign countries began when I was a young student and traveled a lot by train. Thanks to the “Erasmus” European student ex-change program I was able to spend a semester in Sweden. I wrote my degree thesis in Fribourg, Switzerland. The first part of my graduate work was done in Stanford, California; from there I went to Regensburg in Bavaria, Germany to complete my dissertation. After gradu-ating I returned to Switzerland to work at Siegfried in Zofingen. Finally, I now live in Zurich, so I still get to travel a bit – it’s a daily two-hour commute with the train. And I like to use this time for one of my favorite hobbies: reading. I read everything from fantasy and sci-ence fiction, to the classic works and non-fiction books on philosophy and molecular biology.

Of course, I don’t just live in a fantasy world. I am fascinated by all there is to explore in the real world too – on foot, on my bike, or with snowshoes in the winter.

When I get to Zofingen, my time is dedicated to analytical development, an area that ensures the high quality of our formulas. Sometimes we imple-ment our clients’ test methods on our systems, optimize these methods or develop our own, once in a while with

new analysis instruments. I greatly en-joy learning how to use and test new instruments, what can be achieved with the processes and where the lim-its are. In fact, I really like developing and optimizing new things, and later during the validation processes and in daily use, show how well they work. It’s not a good thing when problems pop up – it often means more stress. But the challenge to work hard on a solution is also gratifying – especially when you’ve unraveled a particularly tough problem.

I appreciate my job as an interface be-tween many different departments and people. For example, we discuss the pending jobs and results with the ana-lytical development lab specialists. Then there are the colleagues on the Quality Center team that make sure the methods we’ve developed run reli-ably in daily operation. Quality is a very important aspect that I have come to appreciate and try to integrate in the method development and documenta-tion. We also work closely with the col-leagues in Synthesis; it’s important that we also understand their requirements for a chemical process, so we can de-velop and optimize our processes. Last but not least, a good working re-lationship with the people in produc-tion helps ensure that scaling up to pilot production and finally, to full commercial production is successful. This is the actual goal of our

develop-ment efforts: when a project goes into production, it’s key that we can follow the process exactly and provide sup-port by quickly analyzing and solving any problems that arise. Other impor-tant partners include the Quality Assur-ance team that oversees the creation of our documents according to GMP guidelines. Of course, I also enjoy the contact to our customers, where we reconcile their oftentimes very different demands with the realities at Siegfried. All in all, it’s exciting to work on differ-ent projects with so many people. It motivates me to keep learning anew and stay attuned to emerging chal-lenges. I can never complain about boredom! Often I go to the lab early in the morning, hoping to tackle the next item on my “to do” list. But then, an urgent call from a customer, or some-thing is amiss at the facility, or the chromatogram readouts look a bit strange – and already the day goes by where I’m busy with completely differ-ent things.

Dr. Birgit Timischl

Project Manager / Development
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28 Corporate Governance Group Management From left to right:

Peter A. Gehler, Michael Hüsler, Rudolf Hanko, Ph.D., Marianne Späne, Hubert Stückler, Ph.D., Hanspeter Brun

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4. Executive management

The Chief Executive Officer is responsible for managing the operations and performance of the Group and its Divisions. Subject to the competencies and instructions of the Board of Directors and/or the President, the CEO reports to the Board of Directors and is responsible for implementing and achieving the corporate objectives and for management and control of the Group Divisions and subsidiary companies (with responsibility for earnings and the balance sheet). The powers and tasks of the CEO are set forth in detail in the organizational regulations of the Siegfried Group.

4.1 Members of Group Management

Name Birthyear Position Start In current position since

Rudolf Hanko 1955 Chief Executive Officer 2009 2009

Hanspeter Brun 1948 Head Human Resources 1989 1989

Peter Gehler 1958 Chief Communications Officer, Secretary to the BoD 2000 2002

Michael Hüsler 1972 Chief Financial Officer 2009 2009

Marianne Spähne 1962 President Siegfried Generics Division 2004 2008

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4.2 Portraits

Dr. Rudolf Hanko, CEO

On May 1, 2009, Dr. Rudolf Hanko (1955) took over as CEO of Siegfried. He worked previously in the chemical-pharma-ceutical industry in various management positions, prior to Siegfried with the German company, Evonik Industries AG as head of Custom Synthesis and Amino Acids division. Rudolf Hanko also headed the Pharmaceutical division of Bayer AG as head of Chemical Research and as General Manager of the Fine Chemicals division.

Rudolf Hanko received his Ph.D. in Chemistry from the University of Goettingen, Germany and completed post-doctoral studies at the Max Planck Institute (Germany). Rudolf Hanko is a German citizen.

Hanspeter Brun, Head Human Resources

Hanspeter Brun (1948) joined the Siegfried Group in 1989 as Head of Human Resources, and since 2005, is also the Zofingen Site Manager. Previously, he was responsible for Human Resources and Training at an electrotechnical compa-ny in Zurich. He completed an apprenticeship as a lab assis-tant, and then graduated from the Institute for Applied Psychology (IAP) in Zurich with a degree in Industrial Psychol-ogy. Hanspeter Brun is on the Board of Directors of Parkhaus AG, Zofingen and the Housing Association (Wohnbau-Genossenschaft) Zofingen, and the Landenhof Foundation (Swiss School for the Hearing Impaired), Unterentfelden. Hanspeter Brun is a Swiss citizen.

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Peter A. Gehler, CCO and Secretary to the Board of Directors Peter Gehler (1958) has been Chief Communications Officer of the Siegfried Group since 2000 and also head of the Chairman’s Office since 2002. As Chief Communication Offi-cer, he heads the Corporate Communications Department. Prior to joining Siegfried; he was a marketing and sales manager in the textile industry (1988-92) and an independ-ent consultant for marketing and communications from 1992 until 1999, mainly for industrial and commercial clients. Peter Gehler graduated from the University for Applied Sciences, St Gall with a Business Administration degree (major in Marketing); in 2006 he received his Master degree in Economics and Marketing from the University of Basel. He is a member of the Board of Directors of the Aargau Chamber of Commerce & Industry (AIHK), and Chairman of the Zofingen Regional Chamber of Commerce & Industry (WRZ). Further, he is also member of the Advisory Board to the New Aargauer Bank (NAB) and of the Nische Foundation (for hearing impaired) in Zofingen, and member of the Board of the Soliday Foundation.

Peter Gehler is a Swiss citizen.

Michael Hüsler, CFO

Michael Hüsler (1972) joined Siegfried as Chief Financial Of-ficer on July 1, 2009. He completed his studies in Economics in 1997 at the University of Basel and worked at Pricewater-houseCoopers as an Economic Planner until 2000. From 2000-2005 he was Corporate Controller and finally, Head of Corporate Controlling at Straumann Holding AG. In addi-tion, he completed his studies as a Certified IFRS Accountant in 2004. Michael Hüsler was CFO and member of the execu-tive management at Bachem Holding AG from 2005-2009. Michael Hüsler is a Swiss citizen.

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Marianne Späne, President Siegfried Generics

Marianne Späne (1962) joined Siegfried in 2004. She has headed the Siegfried Generics Division since October 2008 and was previously responsible for the Classical Generics business unit. Between 2004 and January 2008, Marianne Späne managed the Business Development department and the Supply Chain for Generics.

Prior to joining Siegfried, she worked for Boucheron, a cosmetics company, in logistics, business development and as site manager. Later, she changed to the pharmaceutical industry and joined Schweizerhall as a head of the sales and marketing department of the Pharma Division. Later, she joined Aceto, a U.S. company, where she developed European expansion strategies. Marianne Späne holds a degree in finance, business administration and marketing from the Kaufmännische Führungsschule KFS in Basel and the Marketing & Business School in Zurich.

Marianne Späne is a German citizen.

Hubert Stückler, Ph.D., President Siegfried Actives Hubert Stückler (1953) took over as Head of the Siegfried Actives Division in 2004 (then a Business Unit).

Before joining Siegfried, he worked for Chemie Linz in various functions, where he was appointed member of the executive management responsible for R&D, Marketing & Sales, Purchasing and PR. He was promoted to New Business Development Manager after the company was acquired by DSM (The Netherlands) in 1996; he was also member of the ‘Acquisition and Integration’ team during the purchase of the Roche Vitamin Division (2003). He graduated with a Ph.D. from the University of Graz, Austria.

Hubert Stückler is an Austrian citizen.

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4.3 Management Contracts

Siegfried Holding AG and the companies of the Group have not concluded management contracts with any third parties.

5. Compensation, Investments and Loans

5.1 Contents and process for compensation and participation

The members of the Board of Directors are compensated at the level set by the Board of Directors, as recommended by the Board’s Nomination & Compensation committee. Siegfried Group managers receive compensation based on performance, which can range from 5% to 40% of the base salary. The actual component depends on the achievement of business targets within the particular area of responsibility and individual objectives. Achievement of the business targets influences the variable component by a factor of 0 (worst case) and up to a factor of 1.75 (best case). The fac-tors for attaining personal goals lie between 0 and 1.25. The variable component can achieve a maximum factor of 1.5. The Nomination & Compensation committee sets the levels of compensation for executive management.

The period of notice for executive management is six months.

5.2. Employee Stock Option Plan (ESOP)

In August 2005 the Siegfried Group introduced a stock op-tion plan for all Swiss employees. They can invest up to 10% of their income in this option plan to buy Siegfried shares. Board of Director members can participate in the option plan with their entire salary. The subscription rights are subject to a lock-up period of three years. The company contributes a supplement of 30% of the employee’s amount. Employees may opt out or adjust their investment amount in August

of each year. Since September 2005, the investment amount set by each employee is automatically deducted from his or her salary.

A total of 123 employees and 6 members of the Board participated in the stock option plan in 2009.

5.3 Compensation of current and former members of governing bodies

See report on page 110.

5.4 Distribution of shares during 2009

As part of his total compensation, a member of the execu-tive management received 500 shares of Siegfried Holding AG in September 2009, which are locked-in for 3 years. In December 2009, a further member of the executive man-agement received 100 shares as a bonus for the successful project implementation, also with a locked-in period of three years. No further Siegfried Holding AG shares were allotted to any other members of the Board of Directors, Group management, or to persons associated with them during the 2009 business year.

5.5 Share ownership

Ownership of shares by members of the Board of Directors or executive management is listed in the consolidated financial statement of Siegfried Holding AG in this report on page 111.

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5.6 Additional fees and compensation

No members of the Board of Directors, Group Management, or persons associated with them billed either Siegfried Holding AG or any of its Group companies for additional services that equal or exceed by 50% their compensation as a Board member during the 2009 business year.

5.7 Loans to corporate bodies

Members of the Board of Directors or executive manage-ment and/or persons closely associated with them are/were not previously involved in any business activities beyond the usual activities of Siegfried Holding AG or any of its Group companies, or in other extraordinary business activities that are essential to Siegfried Holding AG during the current or the previous business year.

As of 31 December 2009, Siegfried Holding AG and its Group companies have provided no guarantees, loans, advances or credits to members of the Board or Group Management, or to any person associated with them.

6. Voting rights and proxy

6.1 Voting rights and proxy

Each voting share registered at the General Meeting of Shareholders of Siegfried Holding AG is accorded one vote. Registered shareholders can choose to be represented by a legal representative or by another registered shareholder, which requires a written power of attorney.

6.2 Statutory quorums

Decisions are made at the General Meeting of Shareholders by absolute majority of the shares voted, unless otherwise required by law or the statutes. In a tie vote, the President casts the deciding vote.

At least a two-thirds majority of the shares voted and an absolute majority of the share value is required for decisions concerning:

– Amendment of the corporate purpose – Introduction of voting shares

– Amendment of the provisions concerning the transfer of registered shares

– Conversion of registered shares into bearer shares – An authorized or conditional increase in capital – An increase in capital from shareholder’s equity,

from a non-cash capital contribution or asset acquisition, or from the granting of special privileges

– Restriction or cancellation of stock options – Transfer of the company’s legal place of business – Company closure without liquidation

6.3 Calling a General Meeting of Shareholders and setting the agenda

The calling of a General Meeting of Shareholders and setting of the agenda are subject to the applicable legal regulations.

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Shareholders with at least 250,000 shares with voting rights, amounting to a total nominal capital of CHF 500,000 are authorized to propose agenda items for the General Meet-ing, when submitted at least 45 days prior to the General Meeting of Shareholders. Siegfried Holding AG also inquires if these stockholders intend to submit any particular agenda items.

6.4 Entry into the share register/invitation to the General Meeting of April 14, 2010

For the General Meeting the Board of Directors has set a deadline (Wednesday, April 7, 2010, 8:00 a.m.) to determine the eligible shareholders. All participants must be registered in the share register by this time. Admission tickets and voting materials can be ordered with the response card (Siegfried Holding AG, Share Register, c/o Nimbus AG, Post-fach, CH-8866 Ziegelbrücke, Switzerland) by April 9, 2010. Upon receipt of the response card, an admission ticket and the voting materials are sent to the shareholder. No entries will be made into the share register from April 7, 2010, 8 a.m. until April 15, 2010. Shareholders who sell their shares prior to the General Meeting of Shareholders forfeit their voting rights.

The invitation to the General Meeting, the minutes of the previous General Meeting, and the proposals of the Board of Directors can be viewed on the website of Siegfried Holding AG (www.siegfried-holding.com) as of March 23.

7. Control changes and defensive measures

7.1 Duty to offer

There are no statutory regulations regarding opting out or opting up (Art. 22 BEHG).

7.2 Control change clauses

There are no control change clauses.

8. Auditors

8.1 Period of the contract and length of service of the lead auditor

PricewaterhouseCoopers AG (PwC), Basel (or predecessor organizations) has been the auditor of Siegfried Holding AG since 1920. The lead auditor, Dr. M. Jeger, carried out the audits of both mandates for the seventh time in 2009.

8.2 Audit fees and additional fees

PwC billed the Siegfried Group CHF 377,400 during 2009 for services in connection with auditing of the financial statement of Siegfried Holding AG and of the Group companies and the consolidated financial statement of the Siegfried Group. PricewaterhouseCoopers also received CHF 36,000 for tax services. For the auditing of foreign sub-sidiaries CHF 37,000 was paid to other auditing companies; these companies received over CHF 133,000 for further services in 2009.

8.3 Supervision and control instruments related to the audit

As mandated by the Board of Directors, the Audit & Finance committee oversees and evaluates the performance of the external auditors, and advised if PwC should be nominated for re-election at the General Meeting. The parameters used to judge auditor services include technical and operative competency, an independent and objective point of view, application of sufficient resources, a focus on areas of higher risk for Siegfried, presentation of effective and practical rec-ommendations, and open and efficient communication and coordination with the Finance & Audit committee. In 2009, the committee met three times with the PwC representa-tives. Usually, all members of the Finance & Audit commit-tee, the partner and senior PwC manager, our CEO, CFO, and the Chief Communications Officer/Secretary to the Board of Directors attend these meetings. The auditors pre-sent the auditing plans and test results to the committee and submit a comprehensive report to the Board of Directors (as specified by Art. 728b of the Swiss Code of Obligations). Corporate Governance

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The Finance & Audit committee approves, together with the CFO, the remuneration of PwC for auditing and related services.

9. Information policy

The Siegfried Group is committed to an open and consistent information policy. The media, financial analysts and other interest groups are kept up to date on important develop-ments and events. Shareholders are informed semi-annually on the state of the business and receive the annual report and the semi-annual report upon request. The annual report, minutes of the previous General Meeting, media releases, important contacts, and current share price can be found at www.siegfried-holding.com. A news conference is held annually for the media and financial analysts.

Siegfried Holding strictly observes the SIX Swiss Exchange’s duty of disclosure (ad hoc notification) regarding events that could affect the stock price.

In 2010, the company will inform about the course of business as follows:

– March 5, 2010: Publication of results for the 2009 busi-ness year at a media and analyst conference in Zofingen – April 14, 2010: General Assembly of Shareholders

in Zofingen

– August 27, 2010 (tentative): Publication of semi-annual figures at a telephone conference at 9:30 a.m.

– October 28, 2010 (tentative): Publication of business figures for the first nine months of the 2010 business year

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I’ve been a Project Manager with Phar-maceutical Development in Zofingen since September 2008. For Siegfried (and also other companies) I develop medications together with my col-leagues from other departments. We do everything, from the initial feasibili-ty study to formula development, clinic sample production, and up to transfer to pharmaceutical production. That I would end up specializing in pharmaceutical technology came to me relatively late in my studies. At the time I was doing an internship at a galenical development department and because my school had considered this subject as something minor, I soon re-alized there was much more to it than I had previously suspected. And it hasn’t changed since then – I remain fascinat-ed by how many different mfascinat-edications you can produce out of a relatively lim-ited number of materials. After all, it’s these medications that enable a med-ical treatment.

At Siegfried, I enjoy the interdiscipli-nary and international cooperation with the team. The company is just the right size and very manageable, which

allows me to accompany the develop-ment process of a medication from start to finish – and, at the same time, gain remarkable insights into the dif-ferent areas my colleagues work in. And my colleagues helped me when I first arrived here, and they continue to make Zofingen feel so “right.” That’s not as easy as it sounds; I come from the big city of Hamburg, Germany, about 900 km (560 miles) further north. Suddenly finding myself in a small town was a big change, but now I enjoy the luxury of having everything I need just a short walk away. Fortu-nately for me, the reserved manner of the Swiss here is also very similar to my Northern German style.

I like to do sports and meet people outside the office world too. Since moving here I’ve taken up the game of badminton again. Right now I do it just for fun, but I’m improving my tech-nique to get to a more ‘competitive’ level. I’ve taken a break from my sec-ond hobby – salsa dancing – until my partner moves to Switzerland and we’re together again.

The only thing that I miss in Zofingen besides him is the ocean and walking on the beach, where you have to lean into the wind to get anywhere. But I’ll admit that the mountains are increas-ingly attractive and I am now taking time to get to know them better. For example, this winter I decided to learn how to ski.

Dr. Tanja Westphal

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40 Sustainability Report

Content

Introduction Situation

Priorities and scope of action What guides us

Corporate principles

Siegfried as a competitive player Siegfried as a profitable company Siegfried as employer Code of Conduct Corporate Governance Structural foundation Our stakeholders Markets

About the report Compliance Introduction Policies

Inspections and audits

Cooperation with public officials Customer satisfaction

Goals and outlook

Safety, Health and Environment (SHE) Introduction

Guidelines Safety and health Process safety Workplace safety External audits Internal audits

Workplace accidents and illnesses Health

Goals & outlook

Corporate environmental protection General observations Energy consumption Emissions Water consumption Waste Reclaimed solvents Waste solvents

Fines and non-monetary penalties Goals and outlook

Siegfried as an Employer Focus on the employee Working conditions Employee development Apprentices Family-friendly policies Mutual respect Compensation Satisfaction index Social Responsibility Introduction Social responsibility Competition

Sustainable procurement / Personal rights

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IntroductionSituation

‘Sustainability’ is more than a buzzword in the Life Science industry. Regulatory authorities, customers, and users closely watch the activities of every company in this market. Sus-tainability is a central competitive and reputation factor for Siegfried, and carries a high economic value.

We take the expectations of all stakeholders for transparen-cy and honesty seriously. The Board of Directors and Group management contributed to the Report, and they will con-tinue to implement improvements to ensure a high standard of information.

Priorities and scope of action

Within the range of relevant sustainability topics, Siegfried focuses on Compliance, Quality, Safety, Health & Environ-ment (SHE), and our responsibility as an employer. As a rela-tively modest sized company in the Life Science industry, Siegfried has little influence in how the ingredients produced at our facilities are used and consequently, has little contact with the end user. This limits our scope of action.

What guides us

Siegfried offers a capability unique in our market: the devel-opment and production of active ingredients and dosage forms under one roof. Both competencies are based on the same compliance system. The combination of synthesis and formulation represents an attractive market opportunity for the long-term viability of the company (and jobs). These strengths form the key element of our new “Transform” strategy. It will also become evident with the significant infrastructure investments that are planned.

Corporate principles

Siegfried as a competitive player

– We intend to remain an independent company.

– We strive for market leadership in clearly defined market segments – by differentiating ourselves from the competi-tion and gaining a sustainable competitive advantage through the intelligent use of our resources.

– We want to be seen as a service-oriented company; targeted development of technology and know-how serve to enhance our ties to the customer.

Siegfried as a profitable company

– We strive for profit rather than sales growth; especially by sustainably increasing our return on investment. – We intend to grow from an internationally active company

to a global operation. Siegfried as employer

– We strive to avoid risks to the health and well-being of our employees.

– We want to be an attractive employer for highly motivated and talented people that are results-oriented, self-motivated, and work efficiently in a team.

Code of Conduct

In 2008 Siegfried introduced a Code of Conduct policy that specifies our most important policies, such as the role of the employee in ensuring the success of the company, how to deal with conflicts of interest, honesty and trust, bribery and corruption. The Code was distributed to every employee and is part of the introductory program for new employees and valid for all Siegfried sites.

See:

www.siegfried.ch/en/siegfried/company/code-of-conduct

Corporate Governance

The Siegfried Group takes an integrated approach to Corpo-rate Governance and is committed to mutual trust and

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clari-ty toward shareholders, employees, journalists and financial analysts. Our experience with the SWX Swiss Exchange guidelines has shown the importance of sustainable and long-term relationships with all shareholders and stakehold-ers, and a sensible application of corporate governance in-struments. Corporate governance at Siegfried is based on the statutes of Siegfried Ho

References

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