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Long-term smoking alters abundance of over half of the proteome in bronchoalveolar lavage cell in smokers with normal spirometry, with effects on molecular pathways associated with COPD

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Academic year: 2020

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Figure

Fig. 1 Flow chart of the study design outlining groups of the current paper as well as the companion manuscript [15]
Fig. 2 a) Scores plots of OPLS-DA modeling of BAL cell proteome alterations between Smokers (circle) vs Never-smokers (open triangles) OPLS-DA models suggested a perfect separation and predictive power between Smokers and Never-smokers p(CV-ANOVA) = 6.2 ×
Figure S1) with 91% predictive power (R 2 = 0.95, Q 2 = 0.91), driven by 506 significant proteins (|p(corr)[1]| > 0.34, Additional file 1: Table S2).
Figure S2) and lysosomal pathways were both up- and down-regulated (Table 2, Additional file 1: Table S5).
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