PRESENTATION. Adrián Gutiérrez

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PRESENTATION

Adrián Gutiérrez

Science and Technology Counsellor, Embassy of Spain to India

Chief Representative of CDTI India and Southeast Asia, Secretariat of State for Research, Development and Innovation, Ministry of Economy and Competitiveness [email protected]

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Index

1. SPAIN - STI Overview and indicators.

2. Highlights on the Participation of SPAIN in EU FP7 3. Biotech Sector in Spain

4. Indo-Spanish Programme for Technological Co-operation with India in Biotechnology

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2012 = 1.3 %

 In ten years GERD has

more than doubled

 CAGR of 8.9% from

2001-2011

 Financial crisis causing

deceleration in last 3 years

 2013 positive forecast for R&D funding .

1. Spain - STI Overview and Indicators

Source: OECD Main Science and Technology Indicatos 2013/01

8.4 9.8 10.911.8 13.3 16.0 18.3 20.4 20.4 20.2 19.8 0.9% 1.0%1.0% 1.1%1.1% 1.2%1.3% 1.4% 1.4% 1.4% 1.3% 0.0% 0.5% 1.0% 1.5% 2.0% 2.5% 3.0% 0 5 10 15 20 25 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 % G ER D /G D P G ER D in $ b n (P P P )

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1. Spain – STI Overview Indicators – Increasing competitiveness

High implication of private sector with…

…escalating competitiveness

Source: Spanish Science & technology Indicators 2012. National R&D

Observatory, FECYT 19% 52% 28% 0.2% 0% 25% 50% 75% 100% % G ER D b y e xe cu ti o

n Non profit private

organizations Higher Education

Private Sector

Government

Source: Spanish Science & technology Indicators 2012. National R&D

Observatory, FECYT

FM: Framework programme (European funding programme)

0% 3% 6% 9%

FM II FM III FM IV FM V FM VI FM VII Investment (as % of total contribution to UE budget) Return (as % of assigned budget on competitive calls)

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1. Spain – STI Overview and Indicators

 R&D INTENSITY: Spain´s R&D intensity has grown from 0,9% GDP in 2000 to 1.36% in 2012.

 SCIENTIFIC PUBLICATIONS AND IMPACT: 10th Scientific Power in the world by number of publications and 14th scientific power in terms of citations.

– 12% of European scientific production

– 15% of Spanish scientific production in the top ten percent of best scientific production worlwide.

– 78% of the scientific publications published in Spain lead by Spanish principal investigator.

– Exponential growth in number of scientific publications (7.1%) during 1996-2010; way beyond average growth of Western Europe and North America.

 R&D PERSONNEL: 208,831 (12.1 per thousand labour force; 60.7% researchers).

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 PATENT APPLICATIONS (2012) : 262,834 patent applications

– Spain = 0.33% of worlwide number of approved triadic patents.

 HIGH TECH EXPORTS (2012): 11.39 million euros (9% annual growth)

 SPAIN ranks 27TH _{out of 143 countries on the Global Innovation Index} 2014 INSEAD.

 INNOVATIVE BUSINESS SECTOR

– 18,000 firms actively involved in innovation in their business models – Spain ranks 13 among the world's top 2,000 R&D investing firms.

Companies mainly active in the ICT services sector,the pharma and biotech sectors, energy and industrial engineering sectors.

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*PSA – Solar Platform of Almería *Supercomputer Mare Nostrum

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Index

1. SPAIN - STI Overview and indicators

2. Highlights on the Participation of SPAIN in EU FP7

3. Biotech Sector in Spain

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European funding

Support to

universities, R&D

companies, technological centers and other players

2. Highlights on the Participation of SPAIN in EU FP7

Participation in the EU 7th Framework Programme for R&D

7th FP (2007-2013*): Grants of 3.200 M€

The FP is one of the largest sources of project financing in Europe and in Spain

6,5% 8,2%

6th FP: accumulated return 7th FP: accumulated return

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Fondo Europeo de Desarrollo Regional (FEDER)

Una manera de hacer Europa

6th _{LARGEST RECIPIENT UNDER EU FP7}

– Return of 8.3% of the total budget allocated to EU 27

– Increase of leadership of Spanish entities in consortia from 6,3% (FP6) to 10.7% (FP7).

3,200 MILLION EUROS GRANTS FOR SPANISH PARTICIPATING ENTITIES.

TOTAL OF +7,500 SPANISH ENTITIES PARTICIPATED AND SUBMITTED PROPOSALS

UNDER THE DIFFERENT FP7 CALLS / SUCCESS RATE OF SPANISH ENTITIES OF 19.2%.

2,600 SPANISH ENTITIES PARTICIPATE IN SELECTED PROJECTS FOR FUNDING.

– 1,682 out of the total are companies and 75% SMEs. – Participate in 6,000 activities.

– Participate in 3,207 R&D projects, out of which 745 are lead by Spanish principal investigators.

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 SPANISH ENTITIES BY RETURN:

– 31.4% Companies – 22.8% Universities

– 14.7% Public Research Institutions – 11.1% Research Associations

– 11% Technology Centres

 TOP THEMATIC AREAS IN THE COOPERATION PROGRAMME, BY RETURN:

– ICT (610.8 millions of euros)

– NANOSCIENCES, NANOTECHNOLOGY, MATERIALS, NEW MANUFACTURING TECHNOLOGIES (366.3 millions of euros). – HEALTH (267.4 millions euros).

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Index

2. Highlights on the Participation of SPAIN in EU FP7

3. Biotech Sector in Spain

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3. Biotech Sector in Spain

 A young sector, 15 years old.

 Internationalization, is part of its DNA.

 Success depends on the capacity to export.

 Crucial: Joint Projects and Technology Exchange Agreements.

SPAIN

 350% accumulated growth rate in the last 4 years.

 Key player in R&D, spin-offs, research and collaboration.

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 Number of Enterprises: 3,070 (625 EB+2,445 EIB)

 Number of Personnel Employed EB+EIB: 202,976

 Estimated turnover EB+EIB: 80.312 billion euros

 Internal Expenditures on R&D: 523,344 million euros (11.2% increase in comparison to 2009 levels)

 Enterprises related to human health: 55 %

 Enterprises related to Agro-Food: 32.3%

 Enterprises related to industrial processing: 11%

*EB – Biotechnology Enterprise

*EIB – Industrial, commercial or services´ enterprise with interests, developments and products in biotechnology

*Source: ASEBIO Report 2013 2012

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SNAPSHOT: KEY OECD BIOTECH INDICATORS (2012)

 2nd top OECD country, by number of Biotech firms.

 3rd OECD country in terms of R&D public expenditure in 2010

(representing a total of 14,1% of total public R&D expenditure).  8th OECD country in terms of total biotech expenditure of the

business sector investment stood at 794.1 M€ (7.6% of total R&D investment of national companies).

 1,79% share (India 1,11%) of the total number of patents filed by biotech companies under the Patent Co-operation Treaty (PCT

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Contribution to Contribution to GDP 2012 (%) GDP 2012 (%)

1.6

Contribution to Contribution to GDP 2012 (%) GDP 2012 (%)

1.6

Contribution Contribution toto GDP of EB + EIB(%) GDP of EB + EIB(%)

7.8

Contribution Contribution toto GDP of EB + EIB(%) GDP of EB + EIB(%)

7.8

Contribution to GDP (%) Predicted contribution to GDP (%) Employment Predicted employment

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3. Biotech Sector in Spain ENVIRONMENT FOOD AGRICULTURE ANIMAL HEALTH HUMAN HEALTH

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PROFILE OF BIOTECH ENTERPRISES (EB) IN SPAIN

 Between 10 and 20 employees.

 Over 80% of the staff are university graduates.

 Over 25% of the staff devoted to R&D.

 Less than five years of activitiy.

 Located mostly in Madrid, Barcelona, Andalucía, País Vasco and Valencia.

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3. Biotech Sector in Spain SOME SUCCESS STORIES

 2000: Pfizer invested 12 M€ in its European Biometric Centre, with support

functions to the rest of Europe and USA.

 2002: Abengoa signed a 35.5 M USD R&D Agreement with the US

Department of Energy.

 2002: Lilly opened its research centre for medicinal chemistry (one of the

biggest in the world representing an investment of 20 M€)

 2003: Serono concentrates its global growth hormone production in Spain.

 2005: GSK opens Linked its research centre for tropical diseases in Spain.

 2009: Genzyme sets up a sales office in Madrid and a warehouse for

domestic distribution.

 2011: Celgene opens its first research centre outside the USA in Seville. The

Celgene Institute for Translational Research Europe (CITRE) plans to focus on advanced therapies and regenerative medicine.

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SPAIN´S TECHNOLOGICAL STRENGTHS (I)

HEALTH & BIOTECHNOLOGY

Highly competitive industry at the global markets

• Biotech sector: 2nd_{OECD country by number of biotech firms / 3}rd_{by R&D expenditures}

performed by the public sector (OECD Biotechnology Indicators 2012). Strong spin-out culture • Global leader in plasma derived products and therapies (Grifols)

• 5th_{worldwide in exports of health technologies}

• 5th_{ranked country in Europe in number of clinical analysis}

• Spanish model for management of organ transplant considered an international reference. • 2.5% of scientific publications in biotechnology and pharma are produced in Spain (British

Royal Society, 2012)

4th _{Nano biotechnology Scientific production in the world} • Barcelona the 2nd_{Nano biotech city (1}st_Boston)

3rd _{worldwide in agro biotechnology and 5}th _{in biochemistry and molecular biology} Top infrastructures and scientific excellence

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SPAIN´S TECHNOLOGICAL STRENGTHS (II)

HEALTH & BIOTECHNOLOGY

Big network of science parks (bioclusters) Main technologies

• Oncology: Advancell, GP

Pharm, Ingenasa, Pharmamar, IUCT, Lipopharma, Entrechem, Orizon Genomics.

• Cardiology and Neurological: Neuron Pharma, Sanifit

• Oftalmic Optics: Indo, Instituto Fernández Vega, Centro Barraquer, Sylentis, Proretina Therapeutics, Bioftalmik.

• Biotech diagnosis, biomarkers, nanomedicine: Oryzin Genomics, Sistemas Genómicos, AB Biotics, Genomica, Biobide, Pangea Biotech, Genetadi

Biotech, Aromics, Nanotherapy, Nanoinmunotech,…

• Animal Health: Bionaturis, Ingenasa.

• Bioinformatics: Integromics, Noray Bio, Biomol Informatics

• Reproductive technologies (IVI).

• Regenerative medicine, Cell and Gene therapy: Tigenics (former Cellerix)

• Biofuels: Abengoa, Repsol

• E-Health Management and Model - Pioneer in applying solutions such as electronic prescription and digital medical records (Indra, Telefónica, Oesia, Everis).

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INSTITUTIONS SUPPORTING THE SECTOR IN SPAIN : PROMOTING VALUE CREATION THROUGH KNOWLEDGE

• ASEBIO is the Spanish Asociation of Biocompanies

• ASEBIO belongs to and is supported by EUROPABIO, and is a part of CEOE and SEBBM

SPANISH TECHNOLOGY PLATFORMS

• Biotechnology Markets www.medicamentos-innovadores.org

• Nanomedicine www.nanomedspain.net

• Innovative Medicines www.medicamentos-innovadores.org

• Plant Biotechnology www.invegen.org

• Animal Health www.vetmasi.es

• Biomass www.bioplat.org

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Index

2. Highlights on the Participation of SPAIN in EU FP7

3. Biotech Sector in Spain

4. Indo-Spanish Programme for Technological Co-operation with India in Biotechnology

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4. SPANISH Programme for Technological Co-operation with INDIA in Biotechnology TECHNOLOGICAL CO-OPERATION

Centre for the Development of Industrial Technology  Created in 1977

 Public Entity (Ministry of Economy and Competitiveness)  Business innovation financing agency

 Focal point for the promotion of technological innovation  High national and international prestige

Enhance Spanish companies’ competitiveness and internationalization through innovation

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4. SPANISH Programme for Technological Co-operation with INDIA in Biotechnology TECHNOLOGICAL CO-OPERATION

Direct funding to R&D projects (million €)

368 461 896 1.205 917 1.251 1.250 1.380 0 1000 2000 2004 2005 2006 2007 2008 2009 2010 2011

Number of R&D projects approved by CDTI

779 801 1.063 1.154 1.224 1.703 2.315 2.224 0 500 1000 1500 2000 2500 2004 2005 2006 2007 2008 2009 2010 2011

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4. SPANISH Programme of Co-operation with INDIA in Biotechnology

TECHNOLOGICAL CO-OPERATION

RTDI funding

• Evaluation and funding:

• Individual R&D projects

• National Cooperation R&D projects

• Innovation projects

• Internationalization

• Reports towards tax exemption

RTDI internationalization

• Support to technology transfer: Foreign network

• Technology Cooperation:

Eureka, Iberoeka, Eurostars, Eu ropean Framework

Programme…

• International Technology Promotion

Support to the creation and consolidation of new technology based companies

• NEOTEC

• NEOTEC Venture Capital

• INNVIERTE

Aeronautics, Space and Industrial Returns Programmes • Aerospace RTDI • Technological supplies: CERN , Hispasat, Eumetsat…

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4. SPANISH Programme for Technological Co-operation with INDIA in Biotechnology TECHNOLOGICAL CO-OPERATION R+D+I company process CDTI project type Technical risk Funding intensity Precompetitive Research Technological Development Industrial Innovation Technology Internationalization Industrial Research Development Innovation International Technological Promotion Research center collaboration New products/processes development Technology update Technology transfer and promotion RTDI FUNDING

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India – India Spain Innovation Program - Technology Development Board (TDB) - Department of Biotechnology (DBT)

Ministry of New and Renewable Energies (MNRE)

Department of Science and Technology and Global Korea – Korea Spain

Innovating (KSI)

Korea institute for Advancement of Technology (KIAT )

4. SPANISH Programme for Technological Co-operation with INDIA in Biotechnology TECHNOLOGICAL CO-OPERATION Technical risk Bilateral programs Canada - Canadeka National Reseach Council (NRC) SASI South Africa – South

Africa Spain Innovating (SASI)

Technology Innovation Agency (TIA )

JSIP

Japan – Japan Spain

Innovation program (JSIP)

New Energy Industrial Technology Development Organisation (NEDO) India – India Spain Innovation

Program

- Technology Development Board (TDB)

- Department of Biotechnology (DBT)

Ministry of New and Renewable Energies (MNRE)

China - Chineka High Technology Different cultures = different

solutions

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4. SPANISH Programme for Technological

Co-operation with INDIA in Biotechnology

TECHNOLOGICAL CO-OPERATION

Technical risk

• CDTI’s strategy: Identification of High Relevance Countries for Spanish Companies

• CDTI’s delegate in India since 2006

• CDTI’s Institutional Agreements with India:

 TDB (Technology Development Board) since 2006

 DBT (Department of Biotechnology) since 2011

 MNRE (Ministry of Renewable Energy) since 2011

 DST (Department of Science and Technology) and GITA (Global Innovation and Technology Alliance Fund) since 2013

• Calls for Industry-driven R&D proposals in 2014-2015:

– Indo – Spanish Call in Clean Technologies, ICT and Smart Cities (DST/GITA – CDTI)  Opened: 20/11/14 – 15/04/2015

NEW JOINT CALL FOR INDUSTRIAL R&D PROPOSALS TO BE ANNOUNCED BY DBT (India) and CDTI (Spain) in 2015

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4. SPANISH Programme for Technological Co-operation with INDIA in Biotechnology

Technical risk

• Implementing Organizations

• Calls for Proposals

• THEMATIC AREAS: generic call open to collaborative R&D projects in all areas of biotechnology e.g. health biotechnology, industrial biotechnology, nano-biotechnology, agro-biotechnology, including biofuels and bioenergy, bioinformatics and biomedical engineering

• TYPE OF PROPOSALS:

 Development or substantial improvement of new products, processes or services

 Industry-driven and market-oriented R&D projects

 Joint technological co-operation projects between researchers and companies in India and companies in Spain

 Duration of projects: from 1 up to 3 years

Department of Biotechnology Ministry of Science and Technology

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Technical risk

• WHO CAN APPLY?:

 Minimum eligibility criteria: at least one qualified partner from India and one qualified partner from Spain (1+1)

 From the Spanish side the project must necessarily be led by a company, and

 Collaboration with other Spanish R&D

entities (research institutes, academic

institutions, technology centres) is

permitted

 From the Indian side of the consortium can either be led by a company or a research institution

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Technical risk

• HOW TO APPLY?

 Joint R&D&I proposals must be submitted to both of the nodal agencies, DBT and CDTI

 Indian and Spanish co-applicants must elaborate a single project proposal application

CDTI  ISIP application http://www.cdti.es

i. Preliminar Report (spanish)

ii. Application Form (english)

iii. Consortium Agreement (english)

DBT  http://dbtindia.nic.in/

i. Application Form

ii. Consortium Agreement

iii. Funding organisation-specific documents to be

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Technical risk

WHAT CAN BE FINANCED?

• Technical personnel

• Material costs

• Amortisation of assets

• Outsourced technical collaborations

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Technical risk

N° Project Code

Acronym Title Indian

Participants

Spanish Participants 1 IS-20120004 NATURINDIA

DEVELOPMENT OF NUTRACEUTICAL PLANTAS EXTRACTS AND FOOD SUPPLEMENTS BASED ON

THE SYSTEMATIZATION OF INDIAN SYSTEM OF MEDICINE NATURAL REMEDIES PVT. LTD. PLANTAS MEDICINALES DE CATALUÑA, SA

2 IS-20120003 APTAFOOD APTAMER BASED BIOSENSING FOR THE DETECTION OF FOOD TOXINS CENTRAL FOOD TECHNOLOGICAL RESEARCH INSTITUTE-CFTRI LABORATORIO CIFGA, SA 3 IS-20120012 FUNFRUT

DEVELOPMENT OF A NOVEL PROCESS TECHNOLOGY FOR THE COMMERCIAL FREE FRUIT JUICES AND STUDY OF THE END PRODUCT

FUNCTIONAL EFFECT ON LIPID ACCUMULATION

LOYOLA COLLEGE & TVN PRODUCTS

COMPANY

BIOPOLlS S.L.

In the frame of the referred Call, a total of 7 joint R&D project proposals were validly submitted fulfilling all the criteria laid down in

the same text of the Call for Proposals within the deadline • CDTI-DBT ISIP SUCCESS HISTORY (2012)

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Technical risk N° Project Code Acrony m Title Indian Participants Spanish Participants 1 IS-20130001 TRASGLUTA MINASA

STREPTOMICES MOVAERENSES STRAIN

OPTIMIZATION _{BIOSCIENCE PVT.}CLEANERGIS

LTD.

BDF NATURAL INGREDIENTS, S.L.

2 IS-20130002 BIORCAP

BIOSANITARY AND BIOSTIMULANTS PRODUCTS BASED ON THE COMBINATION

OF MICRO-ORGANISMS AND ORGANIC STABILISED BIO-NUTRIENTS

JAY BIOTECH PVT. LTD.

DADELOS, S.L.

In the frame of the referred Call, a total of 6 joint R&D project proposals were validly submitted fulfilling all the criteria laid down in

the same text of the Call for Proposals within the deadline • CDTI-DBT ISIP SUCCESS HISTORY (2013)

NEW JOINT CALL FOR INDUSTRIAL R&D PROPOSALS TO BE ANNOUNCED BY DBT (India) and CDTI (Spain) in 2015

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Thank you!

Adrián Gutiérrez

Science and Technology Counsellor, Embassy of Spain to India

Chief Representative of CDTI India and Southeast Asia, Secretariat of State for Research, Development and Innovation, Ministry of Economy and Competitiveness [email protected]