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06 Pathology

Q world NEET PG TEST

SERIES

www.qworld.co.in

(2)

1 1.The aortic valve seen in the

figure was discovered at the autopsy of a 72-year-old male. The heart weighed 580g, with marked left ventricular hypertrophy and minimal coronary arterial atherosclerosis. A serum chemistry panel revealed no abnormalities prior to death from congestive heart failure. Which of the following pathologic processes accounts for the appearance of the valve ?

A. Amyloidosis

B. Dystrophic calcification C. Lipofuscin deposition D. Hemosiderosis

2. A baby born at 36 weeks' gestation shows the facial features and positioning of extremities shown here. The baby soon develops severe respiratory distress. Which of the following conditions best explains these findings?

A. Congenital rubella infection B. Bilateral renal agenesis C. Maternal diabetes mellitus D. Trisomy 13

3. A 27-year-old woman presents with tender cervical lymphadenopathy.

A biopsy of one of the enlarged lymph nodes in this area isdiagnosed by

the pathologist as being a “reactive lymph node with follicular hyperplasia.”The associated schematic depicts the morphology of this reactive change. The majority of the proliferating cells in the area marked by the arrow labeled with an “*” are in the process of transforming into cells that eventually will secrete which substance? a.Erythropoietin b. Gamma-interferon c. Immunoglobulin d. Interleukin-2 4. A 7-year-old girl presents with signs of acute appendicitis including fever and right lower quadrant abdominal pain. A section from the resected appendix is seen in the associated picture. Which one of the listed laboratory tests is most commonly used to diagnose infection with this organism?

a. Examine the stool with an acid-fast stain

b. Measure vitamin B12 levels in the serum c. Perform an anal “Scotch-tape” test

d. Quantitate the amount of fecal fat in a 24-h stool specimen

5. A 41-year-old woman

presents with increasing fatigue, lethargy,

and muscle weakness. Her CBC reveals decreased numbers of erythrocytes, leukocytes, and platelets along with an increase in the MCV of the

erythrocytes. The

associated picture is from a smear of her peripheral blood. Which of the following substances is most likely to be deficient in this individual?

a. Aminolevulinic acid b. Ascorbic acid c. Folic acid d. Retinoic acid

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2

6 Pigmented liver is seen in  Dubin Johnson

syndrome

 Rotors syndrome C Crigler Najjar

syndrome

D Gilberts syndrome

7 Which of the following is not

true of hepatitis B virus

 Incubation period 6

weeks

 DNA virus C Causes chronic

active hepatitis

D Transmitted

oro-anal route

8 Lipoprotein -- X is elevated i  Hypercholesterolemia  Primary Biliary

Cirrhosia

C Indian Childhood

Cirrhosis

D Alcoholic Cirrhosis

9 In cirrhosis liver all are seen

except

 Loss of normal

architecture

 Degeneration of

hepatocytes

C Fatty infiltrations D Loss of

intercellular connective tissue matrix

10 Nutmeg liver is foundin  Fatty infitration  Amyloidosis C Chronic venous

congestion

D None of the above

11 Non caseating granulomas are

seen in all except

 Byssinosis  Hodgkin's lymphoma C Metastatic Ca lung D TB

12 All increases chances of deep

vein thrombosis except

 OCP  Hypertension C Superficial

thrmbophlebitis

D MI

13 Severe hypovolemic shock occurs

when blood volume less is

 >10 %  > 20% C > 30 % D > 40%

14 Which is least resistant to O2

depletion

 Liver  Heart C Kidney D Spleen

15 Line of Zahn occurs in  Postmortem clot  Infarct C Embolus D Coralline

thrombus

16 Migratory thrmbophlebitis is

seen in

 Disseminated cancer  Rheumatic heart

disease

C Libman Sacks

endocarditis

D All of the above

17 First effect of endotoxin is  Endothelial damage  Perivascular necrosis C DIC D All of the above

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3

19 TLR recognise bacterial products

and stimulate immune response by

 Perforin and

granzyme mediated apoptosis

 FADD ligand apoptosis C Transcription of

nuclear factor mediated by NFKb which recruits cytokine

D Cyclin

20 Toll like receptor involved in

action of bacterial endotoxin

 I  II C III D V

21 Not true regarding superantigen

is

 Bind T-cell irrespctive of antigen specificity of TCR

 bind directly to both

MHC II and TCR causing T-cell activation C Bind to cleft in MHC II Molecule D binds directly to lateral aspect of TCR

22 HLA Class III region genes are

important elements in  transplant rejection phenomenon  Governing suceptibility to autoimmune diseases C Immune surveillance D Antigen presentation and elimination

23 MHC restriction is a part of all

except

 antiviral cytotoxic T -cell

 antibacterial helper

T-cell /cytotoxic T-T-cell

C Allograft rejection D Autoimmune

disorder

24 Mixed lymphocyte culture is

used to identify

 MHC class I antigens  MHC class II antigens C B-lymphocytes D T-helper cells

25 T-cell recognize which antigen in

graft rejection

 MHC II  MHC I C both D none

26 Characteristic feature of SLE is  Uveitis  Joint deformity C Polyserositis D Cavity in lung

27 LE cells is a  lymphocyte  neutrophil C basophil D eosinophil

28 Sicca syndrome is associated

with all except

 Midline granuloma  Chronic active hepatitis C RA D scleroderma

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4

30 Most common primary

immunodeficiency is  Common variable immunodeficiecny  Isolated IgA immunodeficiency C Wiskott-Aldrich syndrome D AIDS

31 Which is found in DiGeorge

syndrome

 Eczema  Mucocutaneous

candidiasis

C Absent B and T cells D Total absence of T

cells

32 IgG is normal or slightly reduced

in all except

 Wiskott-Aldrich

syndrome

 Selective IgA deficiency C DI-George

syndrome

D Common variable

immunodeficiency

33 Shrinking lung is afeature of  SLE  RA C Scleroderma D Sarcoidosis

34 Amyloidosis is seen in all except  Multiple myeloma  Hypernephroma C Thymoma D Lymphoma

35 AA amyloid chain is found in  Multiple myeloma  RA C Gout D Alzheimer's

disease

36 Lardaceous spleen is due to

deposition of amyloid in

 Sinusoids of red pulp  White pulp C Pencilary artery D Splenic trabeculae

37 Speckled pattern is seen in  Anti Sm antibody  Anti ds DNA antibody C Anti histone

antibody

D Anti chromatin

antibody

38 Large antigen-antibody reaction

is required to cause

 Serum sickness  Arthus reaction C Urticaria D Anaphylaxis

39 Mast cell releases all interleukins

except

 IL-1  IL-2 C IL-3 D IL-4

40 Anti-fibrillin antibodies are

associated with

 RA  SLE C Mixed connective

tisssue disease

D Systemic slcerosis

41 All are seen in primary

extraglandular sjogren syndrome except

 RA  Raynaud's

phenomenon

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5

42 Anticentromere antibodies are

most commonly associated with

 Diffuse cutaneous

systemic sclerosis

 Mixed connective

tissue disease

C CREST syndrome D Polymyositis

43 All are immune complex diseases

except

 Serum sickness  Farmer's lung C SLE D Graft rejection

44 Anti-nuclear antibodies in SLE

cause

 Arthritis  LE cell C Endocarditis D CNS lesions

45 NANA antibody is seen in  Sarcoidosis  TB C Leprosy D Carcinoid

46 AE type of amyloid is seen in  Medullary carcinoma

thyroid

 Primary amyloidosis C Multiple myeloma D Familial

amyloidosis

47 Lardaceous spleen is seen in  Alcoholic hepatitis  Chronic active hepatitis C Focal amyloidosis D Diffuse

amyloidosis

48 Serum amyloid associated

protein is found in

 Alzheimer's disease  Chronic inflammatory

states

C Chronic renal failure D Malignant

hypertension

49 Approximate numberof genes in

human genome is

 40000  30000 C 80000 D 100000

50 Lack of differentiation is called  Anaplasia  Dysplasia C Metaplasia D Hyperplasia

51 Transition from G2 to M phase is

controlled by

 Rb protein  p53 protein C Cyclin E D Cyclin B

52 Which of the following is not a

cyclin dependent kinase inhibitor ?

 p21  p27 C p53 D p57

53 Characteristic pathologic

features in malignant hypertension are

 Fibrinoid necrosis  Papillary necrosis C Glomerulosclerosis D Focal

glomerulonephritis

54 In Burkitts Lymphoma

chromosomal translocation is between

 14 and 18  8 and 14 C 14 and 21 D 18 and 21

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56 Morphological changes in

Necrosis

 Enzymatic digestion  Calcium Efflux C Fat accumulation D Fluid accumulation

57 Commonest variety of acute

inflamation is

 Purulent

inflammation

 Serous inflammation C Catarrhal

inflammation

D Necrotic

inflammation

58 Which of the following best

denotes classical complement pathway activation in immuno inflammatiory conditions  C2, C4, and C3 decreaseed  C2 and C4 normal C3 is decreased C C3 normal and C2, C4 decreased D C1 and C3 are normal and decreased

59 The 4 classical features of

inflammation ws decribed by

 Celsus  Hippocrates C Aristotle D Galen

60 Wound contracture is due to  Myofibroblast  Monocyte C Collagen D Elastin

61 Inflammation is usually  Nothing but infection  Adverse reaction C Defence mechanism

of the body

D Suppressed

immunological mechaism

62 AFP is increased in  Endodermal Sinus

tumour

 Teratoma C Dysgerminoma D Choriocarcinoma

63 Metastatic calcification is most

commonly seen in

 Cornea  Extensor tendon C Lungs D Renal tubles

64 Alcohol keratin is composed of  Desmin  Prekeratin filaments C Vimentin D Neurofilaments

65 Pre existing antiboids in Renal

transplantation leads to

 Hyperacute rejection  Acute Rejection C Chronic Rejection D graft Vs Host

Rejection

66 Complement responsible for

activation of baceterial lysis is

 C3a  C3b C C5-9 D C5

67 Medial calcification is seen in  Altheroscloerosis  Arteriotosclerosis C Monckebergs

sclerosis

D Dissecting

aneurysm

68 Most common translocation in

follicular lymphomas

 14 << 18  17 << 19 C 11 << 14 D 22 << 9

69 AIDS involves  T - Helper cells  T- cuppressor C T - cytotoxic D B - cells

70 Chemical mediators or

inflammation includes all, except

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7

71 Therapeutic oxygen therapy is

not useful in

 TOF  Interstitial lung disease C Acute pulmonary

edema

D Anaemia hypoxia

72 Commonest cause of

Hypertriglyceridemia is

 Abetalipoproteinemia  Dysbetalipoprotenemia C LDL receptor

deficiency

D Nephrotic

syndrome

73 Phagocytosis was first stuided

experimentally by

 Virchow  Robert Koch C Domog D Metchnikoff

74 Amyloidosis is associated with  21 P  22 P C Y chromosome D 17 Q

75 Liquefaction necrosis occurs in  Brain  Heart C Liver D Kidneys

76 Antibody production is by  T cells  B cells C K cells D NK cells

77 Following are labile cells except  Hepatocytes  Epithelium of skin C Intestinal mucosa D Bone marrow

78 Glucose-6- phosphate

dehydrogenase (deficiency) is inherited as

 Autosomal dominant  autosomal resessive C X-Linked recessive D X-limked dominant

79 Boydens micropore filter

technique is todemonstrate

 Chemotaxis  Phagocytosis C Defect in leucocytes

function

D None of the above

80 Chediak Higash syndromes is due

to

 Defective chemo taxis  Defective phagocytosis C Both of the above D None of the above

81 The most important mediator of

chemotaxis among following is

 C3b  C5a C C567 D C2

82 Integrins include all the following

Receptor Proteins Except

 Fibronectin  Glycoprotein on platelet surface C Leukocyte adhesion molecule D Platelet derived growth factor

83 Gene preventing nutrition of cell

to propagate and considered as Guardian of genome

 p53 gene  Rb gene C APF D Nf1

84 Syphilitic aneurysm mostly

involve

 Arch of aorta  Descending aorta C Abdominal aorta

above the renal arteries

D Abdominal aorta

below the renal arteries

85 All are labile cells except  Bone marrow cells  Epidermal cells C Living cells of small

intestine

D Hepatocyte

86 Occurrence of leucopenia in

septicemia is due to

 Endotoxin  Bone marrow

suppression

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8

87 The patients with the following

show the maximum deposits of lipofuscin in

 Gauchers disease  Tay Sachs disease C Acute enteric fever D Severe

mainutrition

88 Wathin-Finkeldy gaint cells are

seen in

 Measles  Rubella C Influenza D Rickettsial pox

89 Cytokeratin filaments are seen in  Lipo sarcoma  Neurofibroarcoma C Osteosarcoma D Carcinoma

90 Soft granuloma is typically found

in

 Amoeboma  Leprosy C tuberculosis D Gumma

91 High molecular weight karatins

are expressed mostly in

 Ductal carcinoma breast  Adenocarcinoma stomach C Squamous cell carcinoma D Lymphoma

92 The cell most sensitive to

ischaemia is

 Myocardial fibers  Glial cells of brain C Renal tubular

epithelium

D Cortical neurone

93 Red infarct is encountered in  lung  Heart C Kidney D Spleen

94 In the stage of Grey hepatization  WBC fill the alveoli  RBC fill the alveoli C Organisms fill the

alveoli

D Accumulation of

fibrin

95 ESR is decreased in  Multiple myeloma  Polycythemia C Rheumatic fever D Sickle cell anaemia

96 Keratin is a tumour marker for  Carcinoma cervix  Neurofibroma C Rhabdomyosarcoma D Chorio carcinoma

97 Calcification in necrotic tissue is

called

 Metastatic

calcification

 Dystrophic calcification C Calcinosis D Tumoral calcinosis

98 The function of Liposomes is  Synthesize steroids  Store triglycerides C Cholesterol

breakdown

D Transport

lipoproteins

99 Amtloidosis is seen in all except  Diabetes mellitus  Colloid carcinoma of

throid

C Acute

pyelonephritis

D Multiple myeloma

100 Phagocytosis of TB bacillus does

not occur because of

 Wax D  Muramyl dipeptide C Cord factor D Peritrichate Cilia

101 Immediate transient type of

increase vascular permeability in acute inflammation occurs at

 Venules  Capillaries C Arterioles D All of them

102 In which of the following

conditions bilateral contracted kidneys are characteristically seen?

 Amyloidosis  Diabetes mellitus. C Rapidly progressive

(crescentic)

glomerulonephritis.

D Benign

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103 Which of the following is

associated with adult polycystic kidney disease?  Berry aneurysms in Circle of Willis  Saccular aneurysms of aorta C Fusiform aneurysms of aorta D Leutic aneurysms 104 Following injection of

lymphokines, the same class of immunoglobulin are produced. This is to be referred as:

 Group switching  Clonal selection C Hybridisation D Class switching

105 The release of tissue

thromboplastin is the

mechanism for DIC in all except:

 Massive trauma  Extensive surgery C Severe burn D SLE

106 McCallum’s patch is diagnostic of  Infective endocarditis  Rheumatic

endocarditis

C Myocardial

infarction

D Tetralogy of Fallot

(ToF)

107 Dacrolymus acts through  IL2  IL6 C IL3 D IL4

108 All of the following are involved

in the intrinsic pathway except:

 Factor XII  Factor XI C Factor VII D Factor VIII

109 Which leucotriene is the

adhesion factor for the

neutrophil on the cell surface to attach endothelium

 B4  C4 C D4 D E4

110 All of the following vascular

changes are observed in acute inflammation, except:

 Vasodilation  Stasis of blood C Increased vascular

permeability.

D Decreased

hydrostatic pressure.

111 All of the following are related to

arachidomic acid metabolism except:

 Prostacyclin  Linoleic acid C Thromboxane D Cationic proteins

112 Irreversible injury in cell is  Deposition of Ca++ in

mitochondria

 Mitochondrial swelling C Myelin figure D Ribosomes

detachment

113 All of the following statements

are true for cell againg except :

 Enlargement of telomere  ¯number of mitochondria C Glycolysation of DNA D Glycolysation of RNA

114 All endothelial cells produce

thrombomodulin except those found in:

 Hepatic circulation  Cutaneous circulation C Cerebral

microcirculation

D Renal circulation

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116 The philadelphia chromosome is

classically associated with which of the following

 CLL  CML C Burkits lymphoma D Hairy cell

leukaemia

117 Commonest site of lytic lesion in

multiple myeloma is :

 Vertebral column  Femur C Clavicle D Pelvis

118 Most common type of

thalassemia is :

 Alpha  Beta C Gamma D None of the above

119 All are true about anemia of

chronic disease except :

 Decreased Iron

binding capacity

 Normal serum iron C Increase ferritin D None of the above

120 Macrocytic anaemia is caused by  Sideroblastic anemia  Thallassemia C Hypothyroidism D Iron deficiency

121 Life span of Lymphocytes is  2-3 dyas  Weeks C Months D Many years

122 Blood groups A1 and A2 differ in:  Chemical structure of

antigen

 Spatial configuration of

antigen

C Molecular groups D Ionic charges on

surface

123 All are histicytosis except:  Letter seiwe

syndrome

 Chloroma C

Handschuller-christian triad

D Eosinophilic

granuloma

124 All the following are causes of

pleural effusion except :

 Thyroid tumors  Bronchial carcinoma C Carcinoma breast D Lymphoma

125 Which of the following

histological type lung carcinoma has worst prognosis :

 Squamous cell CA  Adenocarcinoma C Alveolar-carcinoma D Small cell

carcinoma

126 All the following familial

syndromes are associated with development of pheochromocytomas except:  Sturge-Weber syndrome  Von Recklinghausen disease

C MEN Type II D Prader-Willi

syndrome.

127 Chemotherapeutic drugs can

cause

 Only necrosis  Only apoptosis C Both Necrosis and

apoptosis

D Anoikis

128 The tissue of origin of the

Kaposi’s sarcoma is

 Lymphoid  Vascular C Neural 3 D Muscular

129 Which is not a type III

hypersensitivity reaction

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130 Langerhan’s cells are :  Phagocytic cells  Antigen presenting

cells C Seen in Autoimmune conditions D Seen in chronic infection

131 Most common vascular tumour

in AIDS

 Kaposi-sarcoma  Angio sarcoma C Lymphangioma D Lymphoma

132 Rapid progression of disease

with full blown manifestation in AIDS occurs when T4 cell count falls below:

 1000/micro L  500/micro L C 200/micro L D 50/micro L

133 In the mitogen activated protein

kinase pathway, the activation of RAS is counteracted by

 Protein kinase C  GTPase activating

protein

C Phosphatidyl

inositol

D Inositol

triphosphate

134 Which one of the following is not

used as a tumor marker in testicular tumours?

 AFP  LDH C HCG D CEA

135 All of the following are familial cancers except

 Breast carcinoma  Ovarian Ca C Cervical Ca D Colon Ca

136 All are benign mesenchymal

tumours of stomach except:

 Leiomyoma  Adenoma C Fibroma D Lipoma

137 Warthin-Finkeldey giant cells are

seen in:

 Measles  Rubella C Influenza D Rickettsial pox

138 Vascular dilation in the

inflammatory response is mediated by all of the following except:

 Prostaglandins  C3a C Leukotrienes D C5a

139 A single whole body dose of how

many rads could result in death:

 100 rads  200 rads C 300 rads D 400 rads

140 Example of Type IV

hypersensitivity is

 Serum sickness  Granulomatous

reaction

C Schwartzmann

reaction

D Arthus reaction

141 Most common change in

atherosclerotic vessel is  Dystrophic calcification  Superimposed thrombosis C Aneurysm thrombosis D Haemorrhage

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143 The native valve with prior

damage is most commonly affected by which of the following organisms :

 Pepto-streptococci  Staphylococcus aureus C Alpha-hemolytic

streptococci

D Staphylococcus

epidermidis

144 In a patient with acute leukemia,

immunophenotype pattern is CD 19+ve, CD 10+ve, CD33+ve, CD 13+ve. He may probably have

 Biphenotypic

leukemia

 ALL C AML- M2 D AML-M0

145 Sickle cell trait patient do not have manifestations as that of Sickle cell disease, because :

 50% HbS is required

for occurrence of sickling

 HbA prevents sickling C 50% sickles D HbA prevents

polymerazitation of HbS

146 Best prognostic type of

Hodgkin’s lymphoma is:

 Lymphocytic

predominant

 Lymphocytic depletion C Mixed cellularity D Nodular sclerosis

147 All of the following statements

about Hairy cell leukaeumia are true except:  Splenomegaly is conspicuous  Results from an expansion of neoplastic T lymphocytes

C Cells are positive for Tartarate Resistant Acid Phosphatase

D The cells express

CD25 consistently

148 Ameloblastoma (Adamantinoma)

is found in

 Pituitary  Mandible C Tibia D All of the above

149 Histopathology of a lung cancer

shows ‘clara cells’ probable diagnosis is:

 Squamous cell cancer  Bronchio-alveolar

cancer

C Large cell cancer D Papillary

carcinoma

150 All are true about chronic venous

congestion of lung except

 Brown & fibrin lung  Squamous metaplasia C Hemosiderosis D Fibrosis

151 All of the following are seen in

asbestosis except :

 Diffuse alveolar

damage

 Calcify pleural plaques C Diffuse pulmonary

interstitial fibrosis

D Mesotheliomas

152 Macrocytic anemias are seen in

all except

 Orotic aciduria  Thiamine deficiency C Copper deficiency D Liver disease

153 Lacunar cells are seen in which

type of lymphoma

 Lymphocyte

predomiant

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13

154 The blood coagulation time is

prolonged in the following conditions except  Haemophilla  Idiopathic thrombocytopenia C Heparin administration D Afibrogenemia

155 Chronic ITP is due to  increased platelet

consumption intravascular

 Antibody production

against platelets

C Decreased synthesis D Decreased

megakaryocytes

156 Neutrophillia is seen in the

following conditions except

 amoebic liver abscess  Cellulitis C Enteric fever D Lobar pneumonia

157 Dithionite test is done for

assessing

 HbF  HbE C Hb A D Hb S

158 DIC is seen with all of following

except

 Pancreatic carcinoma  Leukemia C Snake bite D AIDS

159 Glanzmans disease is  Cogenital defect of

platelets  Congenital defect of RBcs C Defect of neutrophils D Clotting factor deficiency

160 False about von willebrand factor

is

 Synthesized by

hepatocytes

 Deficiency of factor VIII C

C Defect in platelet

adhesion

D None of the above

161 Which is not associated with

sickle cell anemia

 ankle ulcer  Cardiomegaly C Leucopenia D Fish mouth

vertebra

162 increased osmotic fragility is

seen in

 Sickle cell anaemia  Thalassemia C Hereditary

spherocytosis

D Hemophilia

163 Microcytic hypochromic anaemia

is seen in

 Hereditary

spherocytosis

 Thalassemia C Iron deficiency

anaemia

D Pernicious

anaemia

164 Earliest response to iro therapy is  Increased in Hb %  Reticulocytes C increased PCV D Increased

neutrophils

165 The best suited anticoagulant for

osmotic fragility test is

 Heparin  EDTA C Trisodium citrate D Potassium oxalate

166 Which is abnormal in classic

haemorrhagic disease of newborn

 Platelet count  Thrombin time C Fibrinogen level D APTT

167 In haemolytic uraemic syndrome

there is  Thrombocytopenia + Renal failure  Normal coagulative profile C Microanglopathic haemolytic anaemia

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14

168 The ratio of Bone marrow

responsible for Erythropoiesis to granulopoiesis is

 3 : 1  1 : 1 C 1 : 3 D 4 : 3

169 Karyotypic change of Acute

Promyelecytic Leukemia is

 t 15 : 17  t 18 : 14 C t 8 : 22 D t 11 : 22

170 Platelet count is not decreased in  Wiskot Aldrich

syndrome

 Henoch Schonlein

purpura

C Dengue fever D immune mediated

lysis

171 For enzymatic estimation blood

is not collected in

 EDTA  Sodium fluoride C Sodium citrate D Sodium oxalate

172 Eosinophilia is a feature of  Aspergillosis  Histoplasmosis C Byssiosis D cocidiiomycosis

173 Which does not cause

disseminated intravascular

 Snake bite  Malaria C Hemophilia D Polycythemia

174 One of the following

endocrinologist wrote about primary aldosteronism and the clinical syndrome is named after him

 Cushing  Chevostek C Don Nelson D Conn

175 In neuroblastomas, following

metabolites are excreted in urine except

 HVA  VMA C DOPA D Catecholeamines -

epinephrine

176 Commonest presentation of

Endemic goiter

 Asymptomatic  Hypkothyroidism C Lump in neck D Hyperthyroidism

177 Commonest primary to give

secondaries to adrenal gland is

 Lungs  Breast C Bladder D Pancreas

178 Histopathological indicator of

malignancy in

phaseochromocytoma

 High nuclear index  Pleomorphism C increased mitotic

acitvity

D Vascular invasion

179 Paragangliomas may show

production of

 ACTH  Catecholamines C GH D ADH

180 Commonest cause of ambiguous

genitalia in a 2 yrars old child is

 Klinefelter syndrome  21- hydroxylase

deficiency

C Mixed gonadal

dysgenesis

D Testiular

feminization

181 Amyloid stroma is seen in  Papillary ca. thyroid  Fillicuaar ca. thyroid C anaplastic ca.

thyroid

D Medullary ca.

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182 Medullary ca of thyroid is

associated with increase in

 Calcitonin  Thyroid globulin C T3 D T4

183 Goitrous hypothyroidism

commonly occurs in all of the following except  Hashimotos thyroiditis  Dyshormonogenesis C Thyroprivic hypothyroidism D Iodine deficiency

184 Commonest cause of raised

serum calcium is

 Ectopic secretion  Parathyroid

hyperplasia

C Parathyroid

adenoma

D Parathyroid

carcinoma

185 The levels of 17- ketosteroids in

urine is increased in

 adrenal tumour only  Adrenal and Testicular

tumour

C Liver Secondaries D Bronchongenic

carcinoma

186 Neuroblastoma arises from  Adrenal cortex  Adrenal medulla C Retro peritoneal

mesenchyma

D Endodermal origin

187 Cushings syndrome is most

commonly seen in

 Brochogenic

Carcinoma

 Renal Cell carcinoma C Pancreatic

Carcinoma

D Lymphoma

188 Excretion of which of the

following is icreasedin pheochromocytoma

 Plasma HMA  Serum bradykinin C Urinary VMA D All of the above

189 Which organ is not involves in

MEN Type 1

 Pancreas  Adrenals C Parathyroid D Pituitary

190 Men syndrome is associated with

incrase in

 Papillary ca of thyroid  Medullary C Follicular D Anaplastic

191 normal thyroid weight varies

____ with dietary iodine content

 Directly proportional  Inversely C Inverse cubically D Not fixed

192 The most common

hypersecretory state of anterior pituitary gland

 Growth hormone  Prolactin C ACTH D ADH

193 Thyroglossal cyst may,

occasionally give rise to ______ carcinoma

 Papillary  Medullary C Anaplastic D Follicular

194 To diagnose hyperglycemia of

two weeks old the best investigation retrospectively is

 Ketone bodies  Glycosylated

haemoglobin

C Glucose in the blood D Chromosomal

study

195 Which is true about Addisions

disease

 Hypoglycemia  Hypolalemia C Hypernatremia D Increased protein

(17)

16

196 Condition associated with

obesity is all except

 pheochromocytoma  Hypothyroidism C insulinoma D Cushings

syndrome

197 The following organs are

involved in MEN type I except

 Pituitary  Parathyroid C Pheochromocytoma D Pancreas

198 Which substance is essential for

vit D metabolism

 Parathormone  Calcitonin C Thyroxine D Growth hormone

199 In Hashimotos disease, serum

antibodies are mainly against

 Thyroid follicles  Thyroxine C Thyroglobulins D Iodine

200 Characteristic feature of pagets

cells is

 Eosinophilic

cytoplasm

 Large vacuolated

cytoplasm

C Glycogen mass D Multinucleate

References

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