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Quasispecies:

past, present and future

30

th

anniversary

VIII Jornada de Virologia SCB

Speakers

Christof Biebricher Albert Bosch Carlos Briones Esteban Domingo Manfred Eigen Cecilio López-Galíndez Susanna Manrubia Miguel Angel Martínez Andreas Meyerhans Isabel Novella

Jean-Michel Pawlotsky Juan Carlos Saiz

Francisco Sobrino Ricard Solé

Roger Paredes

Juan Carlos de la Torre Marco Vignuzzi

Simon Wain-Hobson Charles Weissmann

November 17-18, 2008

Institut d´Estudis Catalans, Barcelona, Spain

Scientific Committee

Jordi Gómez, Cecilio López-Galindez,

Miguel Angel Martínez and Antonio Mas Contacts and Registration

Societat Catalana de Biologia, Institut d'Estudis Catalans C/ Carme, 47, 08001 Barcelona Tel. 933 248 584 Fax. 932 701 180 email: [email protected]

http://scb.iec.cat Sponsored by:

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Quasispecies:

past, present and future

30

th

anniversary

VIII Jornada de Virologia SCB

Speakers

Christof Biebricher Albert Bosch Carlos Briones Esteban Domingo Manfred Eigen Cecilio López-Galíndez Susanna Manrubia Miguel Angel Martínez Andreas Meyerhans Isabel Novella

Jean-Michel Pawlotsky Juan Carlos Saiz

Francisco Sobrino Ricard Solé

Roger Paredes

Juan Carlos de la Torre Marco Vignuzzi

Simon Wain-Hobson Charles Weissmann

November 17-18, 2008

Institut d´Estudis Catalans, Barcelona, Spain

Scientific Committee

Jordi Gómez, Cecilio López-Galindez,

Miguel Angel Martínez and Antonio Mas Contacts and Registration

Societat Catalana de Biologia, Institut d'Estudis Catalans C/ Carme, 47, 08001 Barcelona Tel. 933 248 584 Fax. 932 701 180 email: [email protected]

http://scb.iec.cat

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Scope

The first experimental evidence that an RNA virus population

consisted of distributions of mutant genomes, termed quasispecies, was first published 30 years ago by Charles Weissmann, Esteban Domingo and colleagues (Domingo et al. Cell 1978; 13: 735-744). This publication gave experimental support to the first theoretical treatment of a system that replicated with limited fidelity that was developed by Manfred Eigen (Eigen Naturwissenschaften 1971; 58: 465-523) to understand self-organization and adaptability of early life forms in earth. High mutation rates and quasispecies dynamics of RNA viruses are intimately related to viral disease, adaptive potential of viruses and therapeutic antiviral strategies. Moreover, the

quasispecies concept is being applied to other biological systems as tumors, in which a cellular mutant spectrum can be also detected. The meeting will start with a brief historical review of the most relevant findings but it will quickly move to present day questions regarding viral and theoretical quasispecies concepts and its more practical aspects concerning resistances to viral treatments for HIV and HCV and with the discussion of new strategies to treat these and other worldwide viral diseases.

Scientific Committee

Jordi Gómez, Insitituto de Investigación en Parasitología y Biomedicina Lopez Neyra, Granada, Spain, [email protected]

Cecilio López-Galindez, Instituto de Salud Carlos III, Madrid, Spain,

[email protected]

Miguel Angel Martínez, Fundació irsiCiaxa, Badalona, Spain,

[email protected]

Antonio Mas, Universidad de Castilla La Mancha, Albacete, Spain,

[email protected]

Format of the meeting

The meeting will bring together 17 speakers and a maximum of 120 participants (including speakers). The scientific program will start early in the morning of Monday, November 17, and will end around midday on Thursday, November 18. Ample time for informal

discussion will be reserved. Participants will be invited to present a poster.

Organized jointly by the Universidad de Castilla La Mancha and the Societat Catalana de Biologia

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Speakers

Christof Biebricher, Max-Planck-Institute for Biophysical Chemistry, Göetingen, Germany

Albert Bosch, Universitat de Barcelona, Spain

Carlos Briones, Centro de Astrobiología, CSIC-INTA, Madrid, Spain

Esteban Domingo , Centro de Biología Molecular “Severo Ochoa”, CSIC-UAM, Madrid, Spain

Cecilio López-Galíndez, Instituto de Salud Carlos III, Madrid, Spain

Susanna Manrubia, Centro de Astrobiología, CSIC-INTA, Madrid, Spain

Miguel Angel Martínez, Fundació irsiCaixa, Badalona, Spain

Andreas Meyerhans, University of Saarsland, Germany

Isabel Novella, University of Toledo, Ohio, USA

Jean-Michel Pawlotsky, University of Paris XII, France.

Juan Carlos Saiz, Instituto Nacional de Investigaciones Agrarias, Madrid, Spain

Francisco Sobrino, Centro de Biología Molecular “Severo Ochoa”, CSIC-UAM, Madrid, Spain

Ricard Solé, Universitat Pompeu Fabra, Barcelona, Spain and Santa Fe Institute, New Mexico, USA

Roger Paredes, Fundació irsiCaixa, Badalona, Spain

Juan Carlos de la Torre, The Scripps Institute, La Jolla, California, USA

Marco Vignuzzi, Institut Pasteur, Paris, France

Simon Wain-Hobson, Institut Pasteur, Paris, France

Charles Weissmann, The Scripps Institute, Florida, USA

Venue

The meeting will be held in Barcelona, at the Institut d’Estudis Catalans, a XVII century building with conference rooms for 156 participants and a cloister where coffee breaks, lunch and poster

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sessions will take place. Carrer del Carme 47, 08001, Barcelona, Spain

Barcelona

Come on and find out what’s going on in Barcelona by checking out

http://www.bcn.cat/english/ihome.htm

Barcelona city map: http://www.bcn.es/guia/welcomea.htm

Barcelona virtual flight: http://www.bcn.es/volvirtual/en_bcn4d.html How to get to the Institut d´Estudis Catalans

Call for abstracts

Accepted abstracts will be displayed as posters during the entire conference from November 17th until November 18th, 2008. The acceptance decision will be notified by the end of October by

email. A few posters will be selected for a short oral talk.

The abstracts will appear in the booklet distributed among the participants as they have been sent. Please check your abstract

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before posting it. They should be submitted using the abstract submission form below (Fields Last name, First name, Address,

E-mail, Title and Abstract are required). The deadline for submission is

October 17th, 2008.

The official language of the meeting will be English

Abstract should be send to: [email protected]

The posters size should not exceed 2 meters high by 1 meter wide (portrait). If the size is not respected, it will be not possible to

present your poster. Please bring tape to hold it on the metal

poster board (not provided on site).

Guidelines for Abstracts

- Abstracts should be written in English, 200 words maximum. - Use margins of 2,5 cm on left side and 2 cm on right side of the A4 page (21 cm x 29,7 cm).

- Format: word doc.

- Title: Times New Roman Font, size 14; it should be written in

lowercase bold letters at the top of the page.

- Authors: Times New Roman Font, size 12; skip one line after title; Underline name of the presenting author.

- Affiliation: Times New Roman Font, size 12; skip one line after authors' names; Department, Institution, city and country.

- Text: Times New Roman font, size 12; skip one line from affiliation, text should be adjusted to the left.

For any further information concerning your abstract or poster, please contact any member of the Scientific Committee.

Online Registration

Registration fee (TVA included) covers cost for admission to the scientific sessions, abstracts book, coffee breaks and lunch (November 17).

Fees:

Academics: 80€ Students: 50€

Members of the Societat Catalana de Biologia: free

Gala dinner (optional) (Evening November 17, Cloister of the Institut d´Estudis Catalans): 50€

To register go to:

http://scb.iec.cat/quasispecies/inscripcio.asp

Payment: by bank transfer to “la Caixa” 2100-0963-61-0200010607,

References

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