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High neuropeptide Y release associates with Ewing sarcoma bone dissemination - in vivo model of site-specific metastases

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Academic year: 2020

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Figure

Figure 1: TC71 and SK-ES1 ES cells varying in NPY expression and release give rise to invasive primary tumors
Table 1: Comparison of metastatic pattern in SK-ES1 and TC71 orthotopic xenografts.
Figure 2: TC71 xenografts give rise to lung metastases and local relapses, while SK-ES1 xenografts metastasize to soft tissues of the thoracic region, bones and brain
Figure 3: Cells derived from SK-ES1 metastases, SK-ES1-M, exhibit increased motility in the cancer stem cell fraction, enhanced growth in vivo and metastatic potential
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